Platelets Promote Mitochondrial Uncoupling and Resistance to Apoptosis in Leukemia Cells: A Novel Paradigm for the Bone Marrow Microenvironment

Here we report that leukemia cell lines and primary CD34+ leukemic blasts exposed to platelet rich plasma (PRP) or platelet lysates (PL) display increased resistance to apoptosis induced by mitochondria-targeted agents ABT-737 and CDDO-Me. Intriguingly, leukemia cells exposed to platelet components...

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Veröffentlicht in:	Cancer microenvironment 2014-08, Vol.7 (1-2), p.79-90
Hauptverfasser:	Velez, Juliana, Enciso, Leonardo José, Suarez, Marta, Fiegl, Michael, Grismaldo, Adriana, López, Catalina, Barreto, Alfonso, Cardozo, Claudia, Palacios, Pilar, Morales, Ludis, Duque, Jorge Eduardo, Carmona, Jorge Uriel, Konopleva, Marina, Andreeff, Michael, Samudio, Ismael
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedicine Cancer Research Cell Biology Immunology Oncology Original Paper
Online-Zugang:	Volltext
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