Adult-onset temporal lobe epilepsy, cognitive decline, multi-antiepileptic drug hypersensitivity, and Hashimoto's encephalopathy: Two case studies

Adult-onset temporal lobe epilepsy, cognitive decline, multi-antiepileptic drug hypersensitivity, and Hashimoto's encephalopathy: Two case studies

Abstract Hashimoto's encephalopathy is defined by the coexistence of encephalopathy and antithyroid antibodies. We report two cases of adult-onset temporal lobe epilepsy with subacute cognitive decline, high titers of antithyroid antibodies, multi-antiepileptic drug hypersensitivity, and good r...

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Veröffentlicht in:Epilepsy & behavior case reports 2013-01, Vol.1, p.132-135
Hauptverfasser: Sadan, Ofer, Seyman, Estelle, Ash, Elissa L, Kipervasser, Svetlana, Neufeld, Miri Y
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AED
Case Report
Hashimoto's encephalopathy
Hypersensitivity
Neurology
Temporal lobe epilepsy
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creator Sadan, Ofer
Seyman, Estelle
Ash, Elissa L
Kipervasser, Svetlana
Neufeld, Miri Y
description Abstract Hashimoto's encephalopathy is defined by the coexistence of encephalopathy and antithyroid antibodies. We report two cases of adult-onset temporal lobe epilepsy with subacute cognitive decline, high titers of antithyroid antibodies, multi-antiepileptic drug hypersensitivity, and good response to immunomodulatory treatment. The relevance of multidrug hypersensitivity in the setting of adult-onset epilepsy and the importance of searching for autoimmune causes for epilepsy are discussed.
doi_str_mv 10.1016/j.ebcr.2013.07.004
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subjects AED
Case Report
Hashimoto's encephalopathy
Hypersensitivity
Neurology
Temporal lobe epilepsy
title Adult-onset temporal lobe epilepsy, cognitive decline, multi-antiepileptic drug hypersensitivity, and Hashimoto's encephalopathy: Two case studies
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