Synergistic effect of oxymatrine and angiogenesis inhibitor NM-3 on modulating apoptosis in human gastric cancer cells
AIM： To investigate the synergistic effect of oxymatrine （OM） and angiogenesis inhibitor NM-3 on modulating apoptosis in human gastric cancer cell lines SGC-7901, MKN-45, MKN-74. METHODS： Human gastric cancer lines SGC-7901, MKN-45, MKN-74 were treated with OM in the absence and presence of NM-3. Th...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2007-03, Vol.13 (12), p.1788-1793 |
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| creator | Song, Ming-Quan Zhu, Jin-Shui Chen, Jin-Lian Wang, Long Da, Wei Zhu, Li Zhang, Wei-Ping |
| description | AIM： To investigate the synergistic effect of oxymatrine （OM） and angiogenesis inhibitor NM-3 on modulating apoptosis in human gastric cancer cell lines SGC-7901, MKN-45, MKN-74.
METHODS： Human gastric cancer lines SGC-7901, MKN-45, MKN-74 were treated with OM in the absence and presence of NM-3. The inhibitory rates were detected by MTT assay. Synergistic effect of OM and NM-3 on the growth of survivin, bcl-2, bax and p53 in SGC-7901 cells were examined by semiquantitative RTPCR and Western blotting, and their growth inhibitory effects were also observed on SGC-7901 tumor xenograft in nude mice.
RESULTS： OM combined with NM-3 exhibited a synergistic inhibitory effect on the growth of SGC-7901, MKN-45 and MKN-74 cells in a time-dependent manner. Twenty-four hours after treatment with OM, NM-3 alone and their combination, mRNA expression of survivin and bcl-2 in SGC-7901 cells decreased, p53 mRNA expression increased. OM （4 g/L） combined with NM-3 significantly increased the expression of p53 mRNA and decreased the expression of survivin and bcl-2 compared with either agent alone （193% ± 34% vs 129% ± 12%; 44% ± 18% vs 92% ± 18%; 36 ± 17% vs 93% ± 23%, P 〈 0.05）. Western blotting showed that the synergistic effect of OM and NM-3 on protein translation of survivin, bcl-2 and p53 was in accordance with their mRNAs. Furthermore, OM/NM-3 combination obviously exhibited antitumor growth effect in xenografted human gastric cancer cells SGC-7901 compared with either agent alone.
CONCLUSION： OM combined with NM-3 has synergistic inhibitory effects on human gastric cancer cells in vitro and can suppress the growth of xenografted human gastric cancer cells SGC-7901 in vivo. |
| doi_str_mv | 10.3748/wjg.v13.i12.1788 |
| format | Article |
| fullrecord | <record><control><sourceid>wanfang_jour_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4149953</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>24412547</cqvip_id><wanfj_id>wjg200712003</wanfj_id><sourcerecordid>wjg200712003</sourcerecordid><originalsourceid>FETCH-LOGICAL-c450t-19a96b5fcda3cfdc15c166b894636d1734ad590323270d52af4e22aeeddd1dd3</originalsourceid><addsrcrecordid>eNpVkUtvEzEUhS1E1YbSPStkIbaT-jmPDRKqSkEqsKB7644fE4cZO9iTtPn3dZQIysLXC5_7-d5zEHpHyZI3or1-XA_LHeVLT9mSNm37Ci0Yo13FWkFeowUlpKk6zpoL9CbnNSGMc8nO0QVtRC1F3SzQ7tc-2DT4PHuNrXNWzzg6HJ_2E8zJB4shmHIGHwcbbPYZ-7DyvZ9jwj--VxzHgKdotiPMPgwYNnEzx6MMr7YTBDxALiSNNQRtE9Z2HPNbdOZgzPbqdF-ihy-3Dzdfq_ufd99uPt9XWkgyV7SDru6l0wa4dkZTqWld920nal4b2nABRnaEs7IjMZKBE5YxsNYYQ43hl-jTEbvZ9pM12oY5wag2yU-Q9iqCV_-_BL9SQ9wpQUXXSV4AH4-ARwiuuKDWcZtCmVgV61mxl5ZykJGjTKeYc7Lu7xeUqENSB7kqSamSlDokVVrevxztX8MpmiL4cGKuYhj-FHNVD_q386NVTAjKpGj4MyIln2Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Synergistic effect of oxymatrine and angiogenesis inhibitor NM-3 on modulating apoptosis in human gastric cancer cells</title><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Song, Ming-Quan ; Zhu, Jin-Shui ; Chen, Jin-Lian ; Wang, Long ; Da, Wei ; Zhu, Li ; Zhang, Wei-Ping</creator><creatorcontrib>Song, Ming-Quan ; Zhu, Jin-Shui ; Chen, Jin-Lian ; Wang, Long ; Da, Wei ; Zhu, Li ; Zhang, Wei-Ping</creatorcontrib><description>AIM： To investigate the synergistic effect of oxymatrine （OM） and angiogenesis inhibitor NM-3 on modulating apoptosis in human gastric cancer cell lines SGC-7901, MKN-45, MKN-74.
METHODS： Human gastric cancer lines SGC-7901, MKN-45, MKN-74 were treated with OM in the absence and presence of NM-3. The inhibitory rates were detected by MTT assay. Synergistic effect of OM and NM-3 on the growth of survivin, bcl-2, bax and p53 in SGC-7901 cells were examined by semiquantitative RTPCR and Western blotting, and their growth inhibitory effects were also observed on SGC-7901 tumor xenograft in nude mice.
RESULTS： OM combined with NM-3 exhibited a synergistic inhibitory effect on the growth of SGC-7901, MKN-45 and MKN-74 cells in a time-dependent manner. Twenty-four hours after treatment with OM, NM-3 alone and their combination, mRNA expression of survivin and bcl-2 in SGC-7901 cells decreased, p53 mRNA expression increased. OM （4 g/L） combined with NM-3 significantly increased the expression of p53 mRNA and decreased the expression of survivin and bcl-2 compared with either agent alone （193% ± 34% vs 129% ± 12%; 44% ± 18% vs 92% ± 18%; 36 ± 17% vs 93% ± 23%, P 〈 0.05）. Western blotting showed that the synergistic effect of OM and NM-3 on protein translation of survivin, bcl-2 and p53 was in accordance with their mRNAs. Furthermore, OM/NM-3 combination obviously exhibited antitumor growth effect in xenografted human gastric cancer cells SGC-7901 compared with either agent alone.
CONCLUSION： OM combined with NM-3 has synergistic inhibitory effects on human gastric cancer cells in vitro and can suppress the growth of xenografted human gastric cancer cells SGC-7901 in vivo.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v13.i12.1788</identifier><identifier>PMID: 17465467</identifier><language>eng</language><publisher>United States: Department of Gastroenterology, The Sixth Affiliated Hospital of Shanghai Jiaotong University, Shanghai 200233, China</publisher><subject>Alkaloids - pharmacology ; Angiogenesis Inhibitors - pharmacology ; Animals ; Antineoplastic Agents - pharmacology ; Apoptosis - drug effects ; bcl-2-Associated X Protein - genetics ; bcl-2-Associated X Protein - metabolism ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Drug Synergism ; Gastric Cancer ; Gene Expression Regulation, Neoplastic ; Humans ; Inhibitor of Apoptosis Proteins ; Isocoumarins - pharmacology ; Mice ; Mice, Nude ; Microtubule-Associated Proteins - genetics ; Microtubule-Associated Proteins - metabolism ; Neoplasm Proteins - genetics ; Neoplasm Proteins - metabolism ; NM-3 ; Proto-Oncogene Proteins c-bcl-2 - genetics ; Proto-Oncogene Proteins c-bcl-2 - metabolism ; Quinolizines - pharmacology ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Stomach Neoplasms - genetics ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - pathology ; Survivin ; Tumor Suppressor Protein p53 - genetics ; Tumor Suppressor Protein p53 - metabolism ; Xenograft Model Antitumor Assays ; 协同效应 ; 氧化苦参碱 ; 胃癌细胞 ; 血管生成抑制剂</subject><ispartof>World journal of gastroenterology : WJG, 2007-03, Vol.13 (12), p.1788-1793</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>2007 Baishideng Publishing Group Co., Limited. All rights reserved. 2007</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-19a96b5fcda3cfdc15c166b894636d1734ad590323270d52af4e22aeeddd1dd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149953/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149953/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17465467$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Ming-Quan</creatorcontrib><creatorcontrib>Zhu, Jin-Shui</creatorcontrib><creatorcontrib>Chen, Jin-Lian</creatorcontrib><creatorcontrib>Wang, Long</creatorcontrib><creatorcontrib>Da, Wei</creatorcontrib><creatorcontrib>Zhu, Li</creatorcontrib><creatorcontrib>Zhang, Wei-Ping</creatorcontrib><title>Synergistic effect of oxymatrine and angiogenesis inhibitor NM-3 on modulating apoptosis in human gastric cancer cells</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM： To investigate the synergistic effect of oxymatrine （OM） and angiogenesis inhibitor NM-3 on modulating apoptosis in human gastric cancer cell lines SGC-7901, MKN-45, MKN-74.
METHODS： Human gastric cancer lines SGC-7901, MKN-45, MKN-74 were treated with OM in the absence and presence of NM-3. The inhibitory rates were detected by MTT assay. Synergistic effect of OM and NM-3 on the growth of survivin, bcl-2, bax and p53 in SGC-7901 cells were examined by semiquantitative RTPCR and Western blotting, and their growth inhibitory effects were also observed on SGC-7901 tumor xenograft in nude mice.
RESULTS： OM combined with NM-3 exhibited a synergistic inhibitory effect on the growth of SGC-7901, MKN-45 and MKN-74 cells in a time-dependent manner. Twenty-four hours after treatment with OM, NM-3 alone and their combination, mRNA expression of survivin and bcl-2 in SGC-7901 cells decreased, p53 mRNA expression increased. OM （4 g/L） combined with NM-3 significantly increased the expression of p53 mRNA and decreased the expression of survivin and bcl-2 compared with either agent alone （193% ± 34% vs 129% ± 12%; 44% ± 18% vs 92% ± 18%; 36 ± 17% vs 93% ± 23%, P 〈 0.05）. Western blotting showed that the synergistic effect of OM and NM-3 on protein translation of survivin, bcl-2 and p53 was in accordance with their mRNAs. Furthermore, OM/NM-3 combination obviously exhibited antitumor growth effect in xenografted human gastric cancer cells SGC-7901 compared with either agent alone.
CONCLUSION： OM combined with NM-3 has synergistic inhibitory effects on human gastric cancer cells in vitro and can suppress the growth of xenografted human gastric cancer cells SGC-7901 in vivo.</description><subject>Alkaloids - pharmacology</subject><subject>Angiogenesis Inhibitors - pharmacology</subject><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Apoptosis - drug effects</subject><subject>bcl-2-Associated X Protein - genetics</subject><subject>bcl-2-Associated X Protein - metabolism</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Drug Synergism</subject><subject>Gastric Cancer</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Inhibitor of Apoptosis Proteins</subject><subject>Isocoumarins - pharmacology</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Microtubule-Associated Proteins - genetics</subject><subject>Microtubule-Associated Proteins - metabolism</subject><subject>Neoplasm Proteins - genetics</subject><subject>Neoplasm Proteins - metabolism</subject><subject>NM-3</subject><subject>Proto-Oncogene Proteins c-bcl-2 - genetics</subject><subject>Proto-Oncogene Proteins c-bcl-2 - metabolism</subject><subject>Quinolizines - pharmacology</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Stomach Neoplasms - genetics</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - pathology</subject><subject>Survivin</subject><subject>Tumor Suppressor Protein p53 - genetics</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><subject>Xenograft Model Antitumor Assays</subject><subject>协同效应</subject><subject>氧化苦参碱</subject><subject>胃癌细胞</subject><subject>血管生成抑制剂</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtvEzEUhS1E1YbSPStkIbaT-jmPDRKqSkEqsKB7644fE4cZO9iTtPn3dZQIysLXC5_7-d5zEHpHyZI3or1-XA_LHeVLT9mSNm37Ci0Yo13FWkFeowUlpKk6zpoL9CbnNSGMc8nO0QVtRC1F3SzQ7tc-2DT4PHuNrXNWzzg6HJ_2E8zJB4shmHIGHwcbbPYZ-7DyvZ9jwj--VxzHgKdotiPMPgwYNnEzx6MMr7YTBDxALiSNNQRtE9Z2HPNbdOZgzPbqdF-ihy-3Dzdfq_ufd99uPt9XWkgyV7SDru6l0wa4dkZTqWld920nal4b2nABRnaEs7IjMZKBE5YxsNYYQ43hl-jTEbvZ9pM12oY5wag2yU-Q9iqCV_-_BL9SQ9wpQUXXSV4AH4-ARwiuuKDWcZtCmVgV61mxl5ZykJGjTKeYc7Lu7xeUqENSB7kqSamSlDokVVrevxztX8MpmiL4cGKuYhj-FHNVD_q386NVTAjKpGj4MyIln2Q</recordid><startdate>20070328</startdate><enddate>20070328</enddate><creator>Song, Ming-Quan</creator><creator>Zhu, Jin-Shui</creator><creator>Chen, Jin-Lian</creator><creator>Wang, Long</creator><creator>Da, Wei</creator><creator>Zhu, Li</creator><creator>Zhang, Wei-Ping</creator><general>Department of Gastroenterology, The Sixth Affiliated Hospital of Shanghai Jiaotong University, Shanghai 200233, China</general><general>Baishideng Publishing Group Co., Limited</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20070328</creationdate><title>Synergistic effect of oxymatrine and angiogenesis inhibitor NM-3 on modulating apoptosis in human gastric cancer cells</title><author>Song, Ming-Quan ; Zhu, Jin-Shui ; Chen, Jin-Lian ; Wang, Long ; Da, Wei ; Zhu, Li ; Zhang, Wei-Ping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-19a96b5fcda3cfdc15c166b894636d1734ad590323270d52af4e22aeeddd1dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Alkaloids - pharmacology</topic><topic>Angiogenesis Inhibitors - pharmacology</topic><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Apoptosis - drug effects</topic><topic>bcl-2-Associated X Protein - genetics</topic><topic>bcl-2-Associated X Protein - metabolism</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Drug Synergism</topic><topic>Gastric Cancer</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Inhibitor of Apoptosis Proteins</topic><topic>Isocoumarins - pharmacology</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Microtubule-Associated Proteins - genetics</topic><topic>Microtubule-Associated Proteins - metabolism</topic><topic>Neoplasm Proteins - genetics</topic><topic>Neoplasm Proteins - metabolism</topic><topic>NM-3</topic><topic>Proto-Oncogene Proteins c-bcl-2 - genetics</topic><topic>Proto-Oncogene Proteins c-bcl-2 - metabolism</topic><topic>Quinolizines - pharmacology</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Stomach Neoplasms - genetics</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - pathology</topic><topic>Survivin</topic><topic>Tumor Suppressor Protein p53 - genetics</topic><topic>Tumor Suppressor Protein p53 - metabolism</topic><topic>Xenograft Model Antitumor Assays</topic><topic>协同效应</topic><topic>氧化苦参碱</topic><topic>胃癌细胞</topic><topic>血管生成抑制剂</topic><toplevel>online_resources</toplevel><creatorcontrib>Song, Ming-Quan</creatorcontrib><creatorcontrib>Zhu, Jin-Shui</creatorcontrib><creatorcontrib>Chen, Jin-Lian</creatorcontrib><creatorcontrib>Wang, Long</creatorcontrib><creatorcontrib>Da, Wei</creatorcontrib><creatorcontrib>Zhu, Li</creatorcontrib><creatorcontrib>Zhang, Wei-Ping</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Ming-Quan</au><au>Zhu, Jin-Shui</au><au>Chen, Jin-Lian</au><au>Wang, Long</au><au>Da, Wei</au><au>Zhu, Li</au><au>Zhang, Wei-Ping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synergistic effect of oxymatrine and angiogenesis inhibitor NM-3 on modulating apoptosis in human gastric cancer cells</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2007-03-28</date><risdate>2007</risdate><volume>13</volume><issue>12</issue><spage>1788</spage><epage>1793</epage><pages>1788-1793</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM： To investigate the synergistic effect of oxymatrine （OM） and angiogenesis inhibitor NM-3 on modulating apoptosis in human gastric cancer cell lines SGC-7901, MKN-45, MKN-74.
METHODS： Human gastric cancer lines SGC-7901, MKN-45, MKN-74 were treated with OM in the absence and presence of NM-3. The inhibitory rates were detected by MTT assay. Synergistic effect of OM and NM-3 on the growth of survivin, bcl-2, bax and p53 in SGC-7901 cells were examined by semiquantitative RTPCR and Western blotting, and their growth inhibitory effects were also observed on SGC-7901 tumor xenograft in nude mice.
RESULTS： OM combined with NM-3 exhibited a synergistic inhibitory effect on the growth of SGC-7901, MKN-45 and MKN-74 cells in a time-dependent manner. Twenty-four hours after treatment with OM, NM-3 alone and their combination, mRNA expression of survivin and bcl-2 in SGC-7901 cells decreased, p53 mRNA expression increased. OM （4 g/L） combined with NM-3 significantly increased the expression of p53 mRNA and decreased the expression of survivin and bcl-2 compared with either agent alone （193% ± 34% vs 129% ± 12%; 44% ± 18% vs 92% ± 18%; 36 ± 17% vs 93% ± 23%, P 〈 0.05）. Western blotting showed that the synergistic effect of OM and NM-3 on protein translation of survivin, bcl-2 and p53 was in accordance with their mRNAs. Furthermore, OM/NM-3 combination obviously exhibited antitumor growth effect in xenografted human gastric cancer cells SGC-7901 compared with either agent alone.
CONCLUSION： OM combined with NM-3 has synergistic inhibitory effects on human gastric cancer cells in vitro and can suppress the growth of xenografted human gastric cancer cells SGC-7901 in vivo.</abstract><cop>United States</cop><pub>Department of Gastroenterology, The Sixth Affiliated Hospital of Shanghai Jiaotong University, Shanghai 200233, China</pub><pmid>17465467</pmid><doi>10.3748/wjg.v13.i12.1788</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alkaloids - pharmacology Angiogenesis Inhibitors - pharmacology Animals Antineoplastic Agents - pharmacology Apoptosis - drug effects bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Cell Line, Tumor Cell Proliferation - drug effects Drug Synergism Gastric Cancer Gene Expression Regulation, Neoplastic Humans Inhibitor of Apoptosis Proteins Isocoumarins - pharmacology Mice Mice, Nude Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Neoplasm Proteins - genetics Neoplasm Proteins - metabolism NM-3 Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Quinolizines - pharmacology RNA, Messenger - genetics RNA, Messenger - metabolism Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Survivin Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Xenograft Model Antitumor Assays 协同效应 氧化苦参碱 胃癌细胞 血管生成抑制剂 |
| title | Synergistic effect of oxymatrine and angiogenesis inhibitor NM-3 on modulating apoptosis in human gastric cancer cells |
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