Neuroprogressive effects of lifetime illness duration in older adults with bipolar disorder
Objective The aim of the present study was to examine the long‐term effects of bipolar disorder (BD) on brain structure (gray matter volumes). Methods Fifty‐four adults with BD [mean (standard deviation) age = 64.4 (5.4) years] underwent brain MR imaging along with comprehensive clinical assessment....
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| Veröffentlicht in: | Bipolar disorders 2014-09, Vol.16 (6), p.617-623 |
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| container_title | Bipolar disorders |
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| creator | Gildengers, Ariel G Chung, Kuo-Hsuan Huang, Shou-Hung Begley, Amy Aizenstein, Howard J Tsai, Shang-Ying |
| description | Objective
The aim of the present study was to examine the long‐term effects of bipolar disorder (BD) on brain structure (gray matter volumes).
Methods
Fifty‐four adults with BD [mean (standard deviation) age = 64.4 (5.4) years] underwent brain MR imaging along with comprehensive clinical assessment. Total gray matter, hippocampal, and amygdala volumes were extracted using methods developed through the Geriatric Neuroimaging Laboratory at the University of Pittsburgh (Pittsburgh, PA, USA).
Results
Lower total gray matter volumes were related to longer duration of BD, even when controlling for current age and cerebrovascular accident (CVA) risk/burden. Additionally, longer exposure to antipsychotic medication was related to lower gray matter volumes. Lower hippocampal volumes were related to total years of antipsychotic agent exposure and CVA risk/burden scores. Older age was related to lower total gray matter, hippocampal, and amgydala volumes.
Conclusions
Our study of older adults with BD supports the understanding that BD is a neuroprogressive disorder with a longer duration of illness and more antipsychotic agent exposure related to lower gray matter volume. |
| doi_str_mv | 10.1111/bdi.12204 |
| format | Article |
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The aim of the present study was to examine the long‐term effects of bipolar disorder (BD) on brain structure (gray matter volumes).
Methods
Fifty‐four adults with BD [mean (standard deviation) age = 64.4 (5.4) years] underwent brain MR imaging along with comprehensive clinical assessment. Total gray matter, hippocampal, and amygdala volumes were extracted using methods developed through the Geriatric Neuroimaging Laboratory at the University of Pittsburgh (Pittsburgh, PA, USA).
Results
Lower total gray matter volumes were related to longer duration of BD, even when controlling for current age and cerebrovascular accident (CVA) risk/burden. Additionally, longer exposure to antipsychotic medication was related to lower gray matter volumes. Lower hippocampal volumes were related to total years of antipsychotic agent exposure and CVA risk/burden scores. Older age was related to lower total gray matter, hippocampal, and amgydala volumes.
Conclusions
Our study of older adults with BD supports the understanding that BD is a neuroprogressive disorder with a longer duration of illness and more antipsychotic agent exposure related to lower gray matter volume.</description><identifier>ISSN: 1398-5647</identifier><identifier>EISSN: 1399-5618</identifier><identifier>DOI: 10.1111/bdi.12204</identifier><identifier>PMID: 24716786</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Aged ; amygdala ; bipolar disorder ; Bipolar Disorder - pathology ; brain ; Brain - pathology ; Disease Progression ; Female ; Gray Matter - pathology ; hippocampus ; Humans ; Image Processing, Computer-Assisted ; lithium ; Magnetic Resonance Imaging ; Male ; Middle Aged ; neuroimaging ; neuroprogression ; Psychiatric Status Rating Scales ; Regression Analysis</subject><ispartof>Bipolar disorders, 2014-09, Vol.16 (6), p.617-623</ispartof><rights>2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6264-63a08fc8251b2627393c989c891e2830eb6b5ed84eb070e6098b9ca0f63029a23</citedby><cites>FETCH-LOGICAL-c6264-63a08fc8251b2627393c989c891e2830eb6b5ed84eb070e6098b9ca0f63029a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbdi.12204$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbdi.12204$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24716786$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gildengers, Ariel G</creatorcontrib><creatorcontrib>Chung, Kuo-Hsuan</creatorcontrib><creatorcontrib>Huang, Shou-Hung</creatorcontrib><creatorcontrib>Begley, Amy</creatorcontrib><creatorcontrib>Aizenstein, Howard J</creatorcontrib><creatorcontrib>Tsai, Shang-Ying</creatorcontrib><title>Neuroprogressive effects of lifetime illness duration in older adults with bipolar disorder</title><title>Bipolar disorders</title><addtitle>Bipolar Disord</addtitle><description>Objective
The aim of the present study was to examine the long‐term effects of bipolar disorder (BD) on brain structure (gray matter volumes).
Methods
Fifty‐four adults with BD [mean (standard deviation) age = 64.4 (5.4) years] underwent brain MR imaging along with comprehensive clinical assessment. Total gray matter, hippocampal, and amygdala volumes were extracted using methods developed through the Geriatric Neuroimaging Laboratory at the University of Pittsburgh (Pittsburgh, PA, USA).
Results
Lower total gray matter volumes were related to longer duration of BD, even when controlling for current age and cerebrovascular accident (CVA) risk/burden. Additionally, longer exposure to antipsychotic medication was related to lower gray matter volumes. Lower hippocampal volumes were related to total years of antipsychotic agent exposure and CVA risk/burden scores. Older age was related to lower total gray matter, hippocampal, and amgydala volumes.
Conclusions
Our study of older adults with BD supports the understanding that BD is a neuroprogressive disorder with a longer duration of illness and more antipsychotic agent exposure related to lower gray matter volume.</description><subject>Aged</subject><subject>amygdala</subject><subject>bipolar disorder</subject><subject>Bipolar Disorder - pathology</subject><subject>brain</subject><subject>Brain - pathology</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Gray Matter - pathology</subject><subject>hippocampus</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>lithium</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>neuroimaging</subject><subject>neuroprogression</subject><subject>Psychiatric Status Rating Scales</subject><subject>Regression Analysis</subject><issn>1398-5647</issn><issn>1399-5618</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1PFTEYhRuiAUQX_AHSpS4G-jHttBsSRUUMn4kEExdNp_MOFHun13YG5N9buHCDCxO76Zuc5z057UFok5JtWs5O2_ltyhipV9A65VpXQlL14mFWZa6bNfQq52tCqGRErKI1VjdUNkquox_HMKU4T_EyQc7-BjD0Pbgx49jj4HsY_QywD2EoMu6mZEcfB-wHHEMHCdtuCgW-9eMVbv08Bptw53NMRXyNXvY2ZHjzeG-g88-fvu19qQ5P9g_23h9WTjJZV5JbonqnmKAtk6zhmjuttFOaAlOcQCtbAZ2qoSUNAUm0arWzpJecMG0Z30C7C9_51M6gczCMyQYzT35m052J1pu_lcFfmct4Y2paayV5MXj7aJDirwnyaGY-OwjBDhCnbKiQsgQp__cfqFCCcS3vY71boC7FnBP0y0SUmPveTOnNPPRW2K3nT1iST0UVYGcB3PoAd_92Mh8-HjxZVosNn0f4vdyw6aeRDW-EuTjeN2dUn4rvZ0fmK_8DXAyyHw</recordid><startdate>201409</startdate><enddate>201409</enddate><creator>Gildengers, Ariel G</creator><creator>Chung, Kuo-Hsuan</creator><creator>Huang, Shou-Hung</creator><creator>Begley, Amy</creator><creator>Aizenstein, Howard J</creator><creator>Tsai, Shang-Ying</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>201409</creationdate><title>Neuroprogressive effects of lifetime illness duration in older adults with bipolar disorder</title><author>Gildengers, Ariel G ; Chung, Kuo-Hsuan ; Huang, Shou-Hung ; Begley, Amy ; Aizenstein, Howard J ; Tsai, Shang-Ying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6264-63a08fc8251b2627393c989c891e2830eb6b5ed84eb070e6098b9ca0f63029a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>amygdala</topic><topic>bipolar disorder</topic><topic>Bipolar Disorder - pathology</topic><topic>brain</topic><topic>Brain - pathology</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Gray Matter - pathology</topic><topic>hippocampus</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>lithium</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>neuroimaging</topic><topic>neuroprogression</topic><topic>Psychiatric Status Rating Scales</topic><topic>Regression Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gildengers, Ariel G</creatorcontrib><creatorcontrib>Chung, Kuo-Hsuan</creatorcontrib><creatorcontrib>Huang, Shou-Hung</creatorcontrib><creatorcontrib>Begley, Amy</creatorcontrib><creatorcontrib>Aizenstein, Howard J</creatorcontrib><creatorcontrib>Tsai, Shang-Ying</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Bipolar disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gildengers, Ariel G</au><au>Chung, Kuo-Hsuan</au><au>Huang, Shou-Hung</au><au>Begley, Amy</au><au>Aizenstein, Howard J</au><au>Tsai, Shang-Ying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuroprogressive effects of lifetime illness duration in older adults with bipolar disorder</atitle><jtitle>Bipolar disorders</jtitle><addtitle>Bipolar Disord</addtitle><date>2014-09</date><risdate>2014</risdate><volume>16</volume><issue>6</issue><spage>617</spage><epage>623</epage><pages>617-623</pages><issn>1398-5647</issn><eissn>1399-5618</eissn><abstract>Objective
The aim of the present study was to examine the long‐term effects of bipolar disorder (BD) on brain structure (gray matter volumes).
Methods
Fifty‐four adults with BD [mean (standard deviation) age = 64.4 (5.4) years] underwent brain MR imaging along with comprehensive clinical assessment. Total gray matter, hippocampal, and amygdala volumes were extracted using methods developed through the Geriatric Neuroimaging Laboratory at the University of Pittsburgh (Pittsburgh, PA, USA).
Results
Lower total gray matter volumes were related to longer duration of BD, even when controlling for current age and cerebrovascular accident (CVA) risk/burden. Additionally, longer exposure to antipsychotic medication was related to lower gray matter volumes. Lower hippocampal volumes were related to total years of antipsychotic agent exposure and CVA risk/burden scores. Older age was related to lower total gray matter, hippocampal, and amgydala volumes.
Conclusions
Our study of older adults with BD supports the understanding that BD is a neuroprogressive disorder with a longer duration of illness and more antipsychotic agent exposure related to lower gray matter volume.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>24716786</pmid><doi>10.1111/bdi.12204</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged amygdala bipolar disorder Bipolar Disorder - pathology brain Brain - pathology Disease Progression Female Gray Matter - pathology hippocampus Humans Image Processing, Computer-Assisted lithium Magnetic Resonance Imaging Male Middle Aged neuroimaging neuroprogression Psychiatric Status Rating Scales Regression Analysis |
| title | Neuroprogressive effects of lifetime illness duration in older adults with bipolar disorder |
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