141 Gene Discovery and Data Sharing in Genome Wide Association Analyses: lessons form AIDS genetic restriction genes
As genome wide association studies plus whole genome sequence analyses for complex human disease determinants are expanding, it seems useful to develop strategies to facilitate large data sharing, rapid replication and validation of provocative statistical associations that straddle the threshold fo...
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| Veröffentlicht in: | Journal of acquired immune deficiency syndromes (1999) 2014-04, Vol.65 (Suppl 2), p.59-59 |
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| container_end_page | 59 |
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| container_issue | Suppl 2 |
| container_start_page | 59 |
| container_title | Journal of acquired immune deficiency syndromes (1999) |
| container_volume | 65 |
| creator | OʼBrien, Stephen J Svitin, Anton Malov, Sergey Cherkazov, Nikolay Dobrynin, Pavel Geerts, Paul Troyer, Jennifer Hendrickson-Lambert, Sher Sezgin, Efe Hutcheson, Holli |
| description | As genome wide association studies plus whole genome sequence analyses for complex human disease determinants are expanding, it seems useful to develop strategies to facilitate large data sharing, rapid replication and validation of provocative statistical associations that straddle the threshold for genome wide significance. At this conference, we shall announce GWATCH, (Genome Wide Association Tracks Chromosome Highway) a web based data release platform that can freely display and inspect unabridged genome tracked association data without compromising privacy or Informed Consent constrictions, allowing for rapid discovery and replication opportunities. We illustrate the utility with HIV-AIDS resistance genes screened in combined large multicenter cohort studies GWAS (MACS, HGDS, MHGS, ALLIVE, LSOCA HOMER) developed and studied over the last decades. |
| doi_str_mv | 10.1097/01.qai.0000446723.52450.65 |
| format | Article |
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| identifier | ISSN: 1525-4135 |
| ispartof | Journal of acquired immune deficiency syndromes (1999), 2014-04, Vol.65 (Suppl 2), p.59-59 |
| issn | 1525-4135 1944-7884 |
| language | eng |
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| source | Journals@Ovid LWW Legacy Archive; Journals@Ovid Complete; Free E- Journals |
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| title | 141 Gene Discovery and Data Sharing in Genome Wide Association Analyses: lessons form AIDS genetic restriction genes |
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