miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2

Bone-resorbing osteoclasts significantly contribute to osteoporosis and bone metastases of cancer. MicroRNAs play important roles in physiology and disease, and present tremendous therapeutic potential. Nonetheless, how microRNAs regulate skeletal biology is underexplored. Here we identify miR-34a a...

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Veröffentlicht in:	Nature (London) 2014-08, Vol.512 (7515), p.431-435
Hauptverfasser:	Krzeszinski, Jing Y, Wei, Wei, Huynh, HoangDinh, Jin, Zixue, Wang, Xunde, Chang, Tsung-Cheng, Xie, Xian-Jin, He, Lin, Mangala, Lingegowda S, Lopez-Berestein, Gabriel, Sood, Anil K, Mendell, Joshua T, Wan, Yihong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal genetic engineering Animal genetics Animals Base Sequence Bone cancer Bone marrow Bone morphogenetic proteins Bone Neoplasms - genetics Bone Neoplasms - pathology Bone Neoplasms - prevention & control Bone Neoplasms - secondary Bone resorption Bone Resorption - drug therapy Bone Resorption - genetics Breast cancer Cancer Cancer metastasis Cancer prevention Cancer therapies Cell Differentiation - drug effects Cell Differentiation - genetics Cell Line, Tumor Disease Models, Animal Diseases Female Gene Deletion Genetic aspects Genetic engineering Health aspects Homeodomain Proteins - antagonists & inhibitors Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Male Mammary Neoplasms, Animal - pathology Melanoma Metastasis Mice Mice, Transgenic MicroRNA MicroRNAs - genetics MicroRNAs - pharmacology MicroRNAs - therapeutic use Neoplasm Transplantation Novels Oophorectomy Organ Size - drug effects Osteoclasts (Biology) Osteoclasts - drug effects Osteoclasts - pathology Osteoporosis Osteoporosis - genetics Osteoporosis - pathology Osteoporosis - prevention & control Ovariectomy Physiological aspects Prevention Repressor Proteins - antagonists & inhibitors Repressor Proteins - deficiency Repressor Proteins - genetics Repressor Proteins - metabolism Retirement benefits Skin Skin cancer Skin Neoplasms - pathology Studies Tomography Transcription factors Transgenes Xenograft Model Antitumor Assays
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