Genetic Overlap between Evoked Frontocentral Theta-Band Phase Variability, Reaction Time Variability, and Attention-Deficit/Hyperactivity Disorder Symptoms in a Twin Study
Background Electrophysiological and hemodynamic activity is altered in attention-deficit/hyperactivity disorder (ADHD) during tasks requiring cognitive control. Frontal midline theta oscillations are a cortical correlate of cognitive control influencing behavioral outcomes including reaction times....
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| Veröffentlicht in: | Biological psychiatry (1969) 2014-02, Vol.75 (3), p.238-247 |
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| creator | McLoughlin, Gráinne Palmer, Jason A Rijsdijk, Fruhling Makeig, Scott |
| description | Background Electrophysiological and hemodynamic activity is altered in attention-deficit/hyperactivity disorder (ADHD) during tasks requiring cognitive control. Frontal midline theta oscillations are a cortical correlate of cognitive control influencing behavioral outcomes including reaction times. Reaction time variability (RTV) is consistently increased in ADHD and is known to share genetic effects with the disorder. The etiological relationship between the cognitive control system, RTV, and ADHD is unknown. In a sample of twins selected for ADHD and matched control subjects, we aimed to quantify the strength of the phenotypic, genetic, and environmental relationships between event-related midline theta oscillations, RTV, and ADHD. Methods Our sample included 134 participants aged 12 to 15 years: 67 twin pairs (34 monozygotic; 33 dizygotic) with concordance or discordance for ADHD symptomatology assessed at 8, 10, and 12 years of age. Our main outcome measures were frontal midline theta activity, derived from both channel and source decomposed electroencephalographic data, and behavioral performance on a response-choice arrow flanker task known to elicit theta activity. Results Variability in stimulus event-related theta phase from frontal midline cortex is strongly related to both RTV and ADHD, both phenotypically and genetically. Conclusions This is the first finding to confirm the genetic link between the frontal midline cognitive control system and ADHD and the first to identify a genetically related neurophysiological marker of RTV in ADHD. Variability in the timing of the theta signal in ADHD may be part of a dysfunctional brain network that impairs regulation of task-relevant responses in the disorder. |
| doi_str_mv | 10.1016/j.biopsych.2013.07.020 |
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Frontal midline theta oscillations are a cortical correlate of cognitive control influencing behavioral outcomes including reaction times. Reaction time variability (RTV) is consistently increased in ADHD and is known to share genetic effects with the disorder. The etiological relationship between the cognitive control system, RTV, and ADHD is unknown. In a sample of twins selected for ADHD and matched control subjects, we aimed to quantify the strength of the phenotypic, genetic, and environmental relationships between event-related midline theta oscillations, RTV, and ADHD. Methods Our sample included 134 participants aged 12 to 15 years: 67 twin pairs (34 monozygotic; 33 dizygotic) with concordance or discordance for ADHD symptomatology assessed at 8, 10, and 12 years of age. Our main outcome measures were frontal midline theta activity, derived from both channel and source decomposed electroencephalographic data, and behavioral performance on a response-choice arrow flanker task known to elicit theta activity. Results Variability in stimulus event-related theta phase from frontal midline cortex is strongly related to both RTV and ADHD, both phenotypically and genetically. Conclusions This is the first finding to confirm the genetic link between the frontal midline cognitive control system and ADHD and the first to identify a genetically related neurophysiological marker of RTV in ADHD. Variability in the timing of the theta signal in ADHD may be part of a dysfunctional brain network that impairs regulation of task-relevant responses in the disorder.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/j.biopsych.2013.07.020</identifier><identifier>PMID: 24001472</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>ADHD ; Adolescent ; Attention Deficit Disorder with Hyperactivity - genetics ; Attention Deficit Disorder with Hyperactivity - physiopathology ; Attention deficit disorders. Hyperactivity ; Biological and medical sciences ; biomarker ; Child ; Child clinical studies ; cognitive control ; Cohort Studies ; EEG ; Electroencephalography ; Female ; genetic ; Humans ; Male ; Medical sciences ; Models, Genetic ; Neuropsychological Tests ; Phenotype ; Photic Stimulation ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Reaction Time - genetics ; Regression Analysis ; Theta Rhythm - genetics ; twin study ; Twins, Dizygotic ; Twins, Monozygotic</subject><ispartof>Biological psychiatry (1969), 2014-02, Vol.75 (3), p.238-247</ispartof><rights>Society of Biological Psychiatry</rights><rights>2014 Society of Biological Psychiatry</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.</rights><rights>2014 Society of Biological Psychiatry 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c622t-99c2e78b052b90e9015b6977ca079cfc9999ff834c190b0b2dd6f78b72c7f1f93</citedby><cites>FETCH-LOGICAL-c622t-99c2e78b052b90e9015b6977ca079cfc9999ff834c190b0b2dd6f78b72c7f1f93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006322313006744$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28270937$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24001472$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McLoughlin, Gráinne</creatorcontrib><creatorcontrib>Palmer, Jason A</creatorcontrib><creatorcontrib>Rijsdijk, Fruhling</creatorcontrib><creatorcontrib>Makeig, Scott</creatorcontrib><title>Genetic Overlap between Evoked Frontocentral Theta-Band Phase Variability, Reaction Time Variability, and Attention-Deficit/Hyperactivity Disorder Symptoms in a Twin Study</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Background Electrophysiological and hemodynamic activity is altered in attention-deficit/hyperactivity disorder (ADHD) during tasks requiring cognitive control. Frontal midline theta oscillations are a cortical correlate of cognitive control influencing behavioral outcomes including reaction times. Reaction time variability (RTV) is consistently increased in ADHD and is known to share genetic effects with the disorder. The etiological relationship between the cognitive control system, RTV, and ADHD is unknown. In a sample of twins selected for ADHD and matched control subjects, we aimed to quantify the strength of the phenotypic, genetic, and environmental relationships between event-related midline theta oscillations, RTV, and ADHD. Methods Our sample included 134 participants aged 12 to 15 years: 67 twin pairs (34 monozygotic; 33 dizygotic) with concordance or discordance for ADHD symptomatology assessed at 8, 10, and 12 years of age. Our main outcome measures were frontal midline theta activity, derived from both channel and source decomposed electroencephalographic data, and behavioral performance on a response-choice arrow flanker task known to elicit theta activity. Results Variability in stimulus event-related theta phase from frontal midline cortex is strongly related to both RTV and ADHD, both phenotypically and genetically. Conclusions This is the first finding to confirm the genetic link between the frontal midline cognitive control system and ADHD and the first to identify a genetically related neurophysiological marker of RTV in ADHD. Variability in the timing of the theta signal in ADHD may be part of a dysfunctional brain network that impairs regulation of task-relevant responses in the disorder.</description><subject>ADHD</subject><subject>Adolescent</subject><subject>Attention Deficit Disorder with Hyperactivity - genetics</subject><subject>Attention Deficit Disorder with Hyperactivity - physiopathology</subject><subject>Attention deficit disorders. Hyperactivity</subject><subject>Biological and medical sciences</subject><subject>biomarker</subject><subject>Child</subject><subject>Child clinical studies</subject><subject>cognitive control</subject><subject>Cohort Studies</subject><subject>EEG</subject><subject>Electroencephalography</subject><subject>Female</subject><subject>genetic</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Models, Genetic</subject><subject>Neuropsychological Tests</subject><subject>Phenotype</subject><subject>Photic Stimulation</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Reaction Time - genetics</subject><subject>Regression Analysis</subject><subject>Theta Rhythm - genetics</subject><subject>twin study</subject><subject>Twins, Dizygotic</subject><subject>Twins, Monozygotic</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9u1DAQxiMEokvhFSpfkDiQ7djJxptLRelfpEpF7MLVcpwJ621ip7Z3qzwTL4mj3RboBV_G1vzmm7E_J8kRhSkFWhyvp5W2vR_UasqAZlPgU2DwIpnQOc9SlgN7mUwAoEgzxrKD5I3363jkjNHXyUHMA805myS_rtBg0IrcbtG1sicVhgdEQy629g5rcumsCVahCU62ZLnCINPP0tTk60p6JD-k07LSrQ7DR_INpQraGrLU3bPUWHEaQpSJ-fQcG610OL4eenRjzTZC5Fx762p0ZDF0fbCdJ9oQSZYPMSzCph7eJq8a2Xp8t4-HyffLi-XZdXpze_Xl7PQmVQVjIS1LxZDPK5ixqgQsgc6qouRcSeClalQZV9PMs1zREiqoWF0XTeQ5U7yhTZkdJic73X5TdVjvLy96pzvpBmGlFv9mjF6Jn3YrcpqXeTGLAh_2As7eb9AH0WmvsG2lQbvxImLA53lBIaLFDlXOeu-weWpDQYxOi7V4dFqMTgvgIjodC4_-HvKp7NHaCLzfA9Ir2TZOGqX9H27OOJQZj9ynHYfxSbcanfBKo1FYa4cqiNrq_89y8kxCtdro2PUOB_Rru3EmGiao8EyAWIz_cvyWNIsbnufZb1CK49I</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>McLoughlin, Gráinne</creator><creator>Palmer, Jason A</creator><creator>Rijsdijk, Fruhling</creator><creator>Makeig, Scott</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140201</creationdate><title>Genetic Overlap between Evoked Frontocentral Theta-Band Phase Variability, Reaction Time Variability, and Attention-Deficit/Hyperactivity Disorder Symptoms in a Twin Study</title><author>McLoughlin, Gráinne ; Palmer, Jason A ; Rijsdijk, Fruhling ; Makeig, Scott</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c622t-99c2e78b052b90e9015b6977ca079cfc9999ff834c190b0b2dd6f78b72c7f1f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>ADHD</topic><topic>Adolescent</topic><topic>Attention Deficit Disorder with Hyperactivity - genetics</topic><topic>Attention Deficit Disorder with Hyperactivity - physiopathology</topic><topic>Attention deficit disorders. Hyperactivity</topic><topic>Biological and medical sciences</topic><topic>biomarker</topic><topic>Child</topic><topic>Child clinical studies</topic><topic>cognitive control</topic><topic>Cohort Studies</topic><topic>EEG</topic><topic>Electroencephalography</topic><topic>Female</topic><topic>genetic</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Models, Genetic</topic><topic>Neuropsychological Tests</topic><topic>Phenotype</topic><topic>Photic Stimulation</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Reaction Time - genetics</topic><topic>Regression Analysis</topic><topic>Theta Rhythm - genetics</topic><topic>twin study</topic><topic>Twins, Dizygotic</topic><topic>Twins, Monozygotic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McLoughlin, Gráinne</creatorcontrib><creatorcontrib>Palmer, Jason A</creatorcontrib><creatorcontrib>Rijsdijk, Fruhling</creatorcontrib><creatorcontrib>Makeig, Scott</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McLoughlin, Gráinne</au><au>Palmer, Jason A</au><au>Rijsdijk, Fruhling</au><au>Makeig, Scott</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic Overlap between Evoked Frontocentral Theta-Band Phase Variability, Reaction Time Variability, and Attention-Deficit/Hyperactivity Disorder Symptoms in a Twin Study</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2014-02-01</date><risdate>2014</risdate><volume>75</volume><issue>3</issue><spage>238</spage><epage>247</epage><pages>238-247</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Background Electrophysiological and hemodynamic activity is altered in attention-deficit/hyperactivity disorder (ADHD) during tasks requiring cognitive control. Frontal midline theta oscillations are a cortical correlate of cognitive control influencing behavioral outcomes including reaction times. Reaction time variability (RTV) is consistently increased in ADHD and is known to share genetic effects with the disorder. The etiological relationship between the cognitive control system, RTV, and ADHD is unknown. In a sample of twins selected for ADHD and matched control subjects, we aimed to quantify the strength of the phenotypic, genetic, and environmental relationships between event-related midline theta oscillations, RTV, and ADHD. Methods Our sample included 134 participants aged 12 to 15 years: 67 twin pairs (34 monozygotic; 33 dizygotic) with concordance or discordance for ADHD symptomatology assessed at 8, 10, and 12 years of age. Our main outcome measures were frontal midline theta activity, derived from both channel and source decomposed electroencephalographic data, and behavioral performance on a response-choice arrow flanker task known to elicit theta activity. Results Variability in stimulus event-related theta phase from frontal midline cortex is strongly related to both RTV and ADHD, both phenotypically and genetically. Conclusions This is the first finding to confirm the genetic link between the frontal midline cognitive control system and ADHD and the first to identify a genetically related neurophysiological marker of RTV in ADHD. Variability in the timing of the theta signal in ADHD may be part of a dysfunctional brain network that impairs regulation of task-relevant responses in the disorder.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>24001472</pmid><doi>10.1016/j.biopsych.2013.07.020</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | ADHD Adolescent Attention Deficit Disorder with Hyperactivity - genetics Attention Deficit Disorder with Hyperactivity - physiopathology Attention deficit disorders. Hyperactivity Biological and medical sciences biomarker Child Child clinical studies cognitive control Cohort Studies EEG Electroencephalography Female genetic Humans Male Medical sciences Models, Genetic Neuropsychological Tests Phenotype Photic Stimulation Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Reaction Time - genetics Regression Analysis Theta Rhythm - genetics twin study Twins, Dizygotic Twins, Monozygotic |
| title | Genetic Overlap between Evoked Frontocentral Theta-Band Phase Variability, Reaction Time Variability, and Attention-Deficit/Hyperactivity Disorder Symptoms in a Twin Study |
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