Genome Sequence of the Radioresistant Bacterium Deinococcus radiodurans R1
The complete genome sequence of the radiation-resistant bacterium Deinococcus radiodurans R1 is composed of two chromosomes (2,648,638 and 412,348 base pairs), a megaplasmid (177,466 base pairs), and a small plasmid (45,704 base pairs), yielding a total genome of 3,284,156 base pairs. Multiple compo...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1999-11, Vol.286 (5444), p.1571-1577 |
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| creator | White, Owen Eisen, Jonathan A. Heidelberg, John F. Hickey, Erin K. Peterson, Jeremy D. Dodson, Robert J. Haft, Daniel H. Gwinn, Michelle L. Nelson, William C. Richardson, Delwood L. Moffat, Kelly S. Qin, Haiying Jiang, Lingxia Pamphile, Wanda Crosby, Marie Shen, Mian Vamathevan, Jessica J. Lam, Peter McDonald, Lisa Utterback, Terry Zalewski, Celeste Makarova, Kira S. Aravind, L. Daly, Michael J. Minton, Kenneth W. Fleischmann, Robert D. Ketchum, Karen A. Nelson, Karen E. Salzberg, Steven Smith, Hamilton O. Venter, J. Craig Fraser, Claire M. |
| description | The complete genome sequence of the radiation-resistant bacterium Deinococcus radiodurans R1 is composed of two chromosomes (2,648,638 and 412,348 base pairs), a megaplasmid (177,466 base pairs), and a small plasmid (45,704 base pairs), yielding a total genome of 3,284,156 base pairs. Multiple components distributed on the chromosomes and megaplasmid that contribute to the ability of D. radiodurans to survive under conditions of starvation, oxidative stress, and high amounts of DNA damage were identified. Deinococcus radiodurans represents an organism in which all systems for DNA repair, DNA damage export, desiccation and starvation recovery, and genetic redundancy are present in one cell. |
| doi_str_mv | 10.1126/science.286.5444.1571 |
| format | Article |
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Craig ; Fraser, Claire M.</creator><creatorcontrib>White, Owen ; Eisen, Jonathan A. ; Heidelberg, John F. ; Hickey, Erin K. ; Peterson, Jeremy D. ; Dodson, Robert J. ; Haft, Daniel H. ; Gwinn, Michelle L. ; Nelson, William C. ; Richardson, Delwood L. ; Moffat, Kelly S. ; Qin, Haiying ; Jiang, Lingxia ; Pamphile, Wanda ; Crosby, Marie ; Shen, Mian ; Vamathevan, Jessica J. ; Lam, Peter ; McDonald, Lisa ; Utterback, Terry ; Zalewski, Celeste ; Makarova, Kira S. ; Aravind, L. ; Daly, Michael J. ; Minton, Kenneth W. ; Fleischmann, Robert D. ; Ketchum, Karen A. ; Nelson, Karen E. ; Salzberg, Steven ; Smith, Hamilton O. ; Venter, J. Craig ; Fraser, Claire M.</creatorcontrib><description>The complete genome sequence of the radiation-resistant bacterium Deinococcus radiodurans R1 is composed of two chromosomes (2,648,638 and 412,348 base pairs), a megaplasmid (177,466 base pairs), and a small plasmid (45,704 base pairs), yielding a total genome of 3,284,156 base pairs. Multiple components distributed on the chromosomes and megaplasmid that contribute to the ability of D. radiodurans to survive under conditions of starvation, oxidative stress, and high amounts of DNA damage were identified. Deinococcus radiodurans represents an organism in which all systems for DNA repair, DNA damage export, desiccation and starvation recovery, and genetic redundancy are present in one cell.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.286.5444.1571</identifier><identifier>PMID: 10567266</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Amino acids ; Bacteria ; Bacterial Proteins - biosynthesis ; Bacterial Proteins - chemistry ; Bacterial Proteins - genetics ; Bacteriology ; Biological and medical sciences ; Catalase - genetics ; Chromosomes ; Chromosomes, Bacterial - genetics ; Coding ; Deinococcus radiodurans ; DNA ; DNA Damage ; DNA repair ; DNA Repair - genetics ; DNA, Bacterial - genetics ; Energy Metabolism ; Fundamental and applied biological sciences. Psychology ; Genes ; Genes, Bacterial ; Genetics ; Genome, Bacterial ; Genomes ; Gram-Positive Cocci - chemistry ; Gram-Positive Cocci - classification ; Gram-Positive Cocci - genetics ; Gram-Positive Cocci - radiation effects ; Microbiology ; Molecular Sequence Data ; Observation ; Open Reading Frames ; Oxidative Stress ; Physical Chromosome Mapping ; Plasmids ; Radiation damage ; Radiation Tolerance ; Repetitive Sequences, Nucleic Acid ; Sequence Analysis, DNA ; Statistical Analysis ; Superoxide Dismutase - genetics ; Thermus - chemistry ; Thermus - genetics ; Ultraviolet Rays</subject><ispartof>Science (American Association for the Advancement of Science), 1999-11, Vol.286 (5444), p.1571-1577</ispartof><rights>Copyright 1999 American Association for the Advancement of Science</rights><rights>2000 INIST-CNRS</rights><rights>COPYRIGHT 1999 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1999 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Nov 19, 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c824t-552fbad63f0e730d1df14af9ae5155e67e4aa618fa5d88570b29462a3960933a3</citedby><cites>FETCH-LOGICAL-c824t-552fbad63f0e730d1df14af9ae5155e67e4aa618fa5d88570b29462a3960933a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2899828$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2899828$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1274879$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10567266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>White, Owen</creatorcontrib><creatorcontrib>Eisen, Jonathan A.</creatorcontrib><creatorcontrib>Heidelberg, John F.</creatorcontrib><creatorcontrib>Hickey, Erin K.</creatorcontrib><creatorcontrib>Peterson, Jeremy D.</creatorcontrib><creatorcontrib>Dodson, Robert J.</creatorcontrib><creatorcontrib>Haft, Daniel H.</creatorcontrib><creatorcontrib>Gwinn, Michelle L.</creatorcontrib><creatorcontrib>Nelson, William C.</creatorcontrib><creatorcontrib>Richardson, Delwood L.</creatorcontrib><creatorcontrib>Moffat, Kelly S.</creatorcontrib><creatorcontrib>Qin, Haiying</creatorcontrib><creatorcontrib>Jiang, Lingxia</creatorcontrib><creatorcontrib>Pamphile, Wanda</creatorcontrib><creatorcontrib>Crosby, Marie</creatorcontrib><creatorcontrib>Shen, Mian</creatorcontrib><creatorcontrib>Vamathevan, Jessica J.</creatorcontrib><creatorcontrib>Lam, Peter</creatorcontrib><creatorcontrib>McDonald, Lisa</creatorcontrib><creatorcontrib>Utterback, Terry</creatorcontrib><creatorcontrib>Zalewski, Celeste</creatorcontrib><creatorcontrib>Makarova, Kira S.</creatorcontrib><creatorcontrib>Aravind, L.</creatorcontrib><creatorcontrib>Daly, Michael J.</creatorcontrib><creatorcontrib>Minton, Kenneth W.</creatorcontrib><creatorcontrib>Fleischmann, Robert D.</creatorcontrib><creatorcontrib>Ketchum, Karen A.</creatorcontrib><creatorcontrib>Nelson, Karen E.</creatorcontrib><creatorcontrib>Salzberg, Steven</creatorcontrib><creatorcontrib>Smith, Hamilton O.</creatorcontrib><creatorcontrib>Venter, J. Craig</creatorcontrib><creatorcontrib>Fraser, Claire M.</creatorcontrib><title>Genome Sequence of the Radioresistant Bacterium Deinococcus radiodurans R1</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The complete genome sequence of the radiation-resistant bacterium Deinococcus radiodurans R1 is composed of two chromosomes (2,648,638 and 412,348 base pairs), a megaplasmid (177,466 base pairs), and a small plasmid (45,704 base pairs), yielding a total genome of 3,284,156 base pairs. Multiple components distributed on the chromosomes and megaplasmid that contribute to the ability of D. radiodurans to survive under conditions of starvation, oxidative stress, and high amounts of DNA damage were identified. Deinococcus radiodurans represents an organism in which all systems for DNA repair, DNA damage export, desiccation and starvation recovery, and genetic redundancy are present in one cell.</description><subject>Amino acids</subject><subject>Bacteria</subject><subject>Bacterial Proteins - biosynthesis</subject><subject>Bacterial Proteins - chemistry</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Catalase - genetics</subject><subject>Chromosomes</subject><subject>Chromosomes, Bacterial - genetics</subject><subject>Coding</subject><subject>Deinococcus radiodurans</subject><subject>DNA</subject><subject>DNA Damage</subject><subject>DNA repair</subject><subject>DNA Repair - genetics</subject><subject>DNA, Bacterial - genetics</subject><subject>Energy Metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes</subject><subject>Genes, Bacterial</subject><subject>Genetics</subject><subject>Genome, Bacterial</subject><subject>Genomes</subject><subject>Gram-Positive Cocci - chemistry</subject><subject>Gram-Positive Cocci - classification</subject><subject>Gram-Positive Cocci - genetics</subject><subject>Gram-Positive Cocci - radiation effects</subject><subject>Microbiology</subject><subject>Molecular Sequence Data</subject><subject>Observation</subject><subject>Open Reading Frames</subject><subject>Oxidative Stress</subject><subject>Physical Chromosome Mapping</subject><subject>Plasmids</subject><subject>Radiation damage</subject><subject>Radiation Tolerance</subject><subject>Repetitive Sequences, Nucleic Acid</subject><subject>Sequence Analysis, DNA</subject><subject>Statistical Analysis</subject><subject>Superoxide Dismutase - genetics</subject><subject>Thermus - chemistry</subject><subject>Thermus - genetics</subject><subject>Ultraviolet Rays</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN011v0zAUBuAIgVgZ_ANA0YSAi7X4284N0lagDFVU2oBby3VOOleJPeIEwb_HUauxogqqXETKeXzkE503y55hNMGYiDfROvAWJkSJCWeMTTCX-F42wqjg44Igej8bIUTFWCHJj7JHMa4RSrWCPsyOMOJCEiFG2acZ-NBAfgXf-6FfHqq8u4b80pQutBBd7Izv8nNjO2hd3-TvwPlgg7V9zNsBlX1rfMwv8ePsQWXqCE-27-Ps64f3X6Yfx_PF7GJ6Nh9bRVg35pxUS1MKWiGQFJW4rDAzVWGAY85BSGDGCKwqw0uluERLUjBBDC0EKig19Dh7u-l70y8bKC34rjW1vmldY9pfOhindyveXetV-KEZZlISmhq82jZoQ5o6drpx0UJdGw-hj1oyKhRGVCb58p9SFCRdif0fYkk5SRMkePIXXIe-9el_aYIpV4QXQ7fTDVqZGrTzVUhz2BV4SOMED5VLn8-4QlRhzBMf7-HpKaFxdp9_veMT6eBntzJ9jPri6vPBdPHtYHo-O5Sq2XyHnu6jNtQ1rECnxZoudjjfcNuGGFuobtcCIz3kRm9zo1Nu9JAbPeQmnXt-d6funNoEJYEXW2CiNXWVdt66-McRyZQsEnu6YevYhfa2TFRRKKLob8KHJmI</recordid><startdate>19991119</startdate><enddate>19991119</enddate><creator>White, Owen</creator><creator>Eisen, Jonathan A.</creator><creator>Heidelberg, John F.</creator><creator>Hickey, Erin K.</creator><creator>Peterson, Jeremy D.</creator><creator>Dodson, Robert J.</creator><creator>Haft, Daniel H.</creator><creator>Gwinn, Michelle L.</creator><creator>Nelson, William C.</creator><creator>Richardson, Delwood L.</creator><creator>Moffat, Kelly S.</creator><creator>Qin, Haiying</creator><creator>Jiang, Lingxia</creator><creator>Pamphile, Wanda</creator><creator>Crosby, Marie</creator><creator>Shen, Mian</creator><creator>Vamathevan, Jessica J.</creator><creator>Lam, Peter</creator><creator>McDonald, Lisa</creator><creator>Utterback, Terry</creator><creator>Zalewski, Celeste</creator><creator>Makarova, Kira S.</creator><creator>Aravind, L.</creator><creator>Daly, Michael J.</creator><creator>Minton, Kenneth W.</creator><creator>Fleischmann, Robert D.</creator><creator>Ketchum, Karen A.</creator><creator>Nelson, Karen E.</creator><creator>Salzberg, Steven</creator><creator>Smith, Hamilton O.</creator><creator>Venter, J. 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Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>University of Michigan</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>White, Owen</au><au>Eisen, Jonathan A.</au><au>Heidelberg, John F.</au><au>Hickey, Erin K.</au><au>Peterson, Jeremy D.</au><au>Dodson, Robert J.</au><au>Haft, Daniel H.</au><au>Gwinn, Michelle L.</au><au>Nelson, William C.</au><au>Richardson, Delwood L.</au><au>Moffat, Kelly S.</au><au>Qin, Haiying</au><au>Jiang, Lingxia</au><au>Pamphile, Wanda</au><au>Crosby, Marie</au><au>Shen, Mian</au><au>Vamathevan, Jessica J.</au><au>Lam, Peter</au><au>McDonald, Lisa</au><au>Utterback, Terry</au><au>Zalewski, Celeste</au><au>Makarova, Kira S.</au><au>Aravind, L.</au><au>Daly, Michael J.</au><au>Minton, Kenneth W.</au><au>Fleischmann, Robert D.</au><au>Ketchum, Karen A.</au><au>Nelson, Karen E.</au><au>Salzberg, Steven</au><au>Smith, Hamilton O.</au><au>Venter, J. Craig</au><au>Fraser, Claire M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genome Sequence of the Radioresistant Bacterium Deinococcus radiodurans R1</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1999-11-19</date><risdate>1999</risdate><volume>286</volume><issue>5444</issue><spage>1571</spage><epage>1577</epage><pages>1571-1577</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>The complete genome sequence of the radiation-resistant bacterium Deinococcus radiodurans R1 is composed of two chromosomes (2,648,638 and 412,348 base pairs), a megaplasmid (177,466 base pairs), and a small plasmid (45,704 base pairs), yielding a total genome of 3,284,156 base pairs. Multiple components distributed on the chromosomes and megaplasmid that contribute to the ability of D. radiodurans to survive under conditions of starvation, oxidative stress, and high amounts of DNA damage were identified. Deinococcus radiodurans represents an organism in which all systems for DNA repair, DNA damage export, desiccation and starvation recovery, and genetic redundancy are present in one cell.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>10567266</pmid><doi>10.1126/science.286.5444.1571</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1999-11, Vol.286 (5444), p.1571-1577 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4147723 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Amino acids Bacteria Bacterial Proteins - biosynthesis Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacteriology Biological and medical sciences Catalase - genetics Chromosomes Chromosomes, Bacterial - genetics Coding Deinococcus radiodurans DNA DNA Damage DNA repair DNA Repair - genetics DNA, Bacterial - genetics Energy Metabolism Fundamental and applied biological sciences. Psychology Genes Genes, Bacterial Genetics Genome, Bacterial Genomes Gram-Positive Cocci - chemistry Gram-Positive Cocci - classification Gram-Positive Cocci - genetics Gram-Positive Cocci - radiation effects Microbiology Molecular Sequence Data Observation Open Reading Frames Oxidative Stress Physical Chromosome Mapping Plasmids Radiation damage Radiation Tolerance Repetitive Sequences, Nucleic Acid Sequence Analysis, DNA Statistical Analysis Superoxide Dismutase - genetics Thermus - chemistry Thermus - genetics Ultraviolet Rays |
| title | Genome Sequence of the Radioresistant Bacterium Deinococcus radiodurans R1 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T03%3A42%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genome%20Sequence%20of%20the%20Radioresistant%20Bacterium%20Deinococcus%20radiodurans%20R1&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=White,%20Owen&rft.date=1999-11-19&rft.volume=286&rft.issue=5444&rft.spage=1571&rft.epage=1577&rft.pages=1571-1577&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.286.5444.1571&rft_dat=%3Cgale_pubme%3EA58038115%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213582597&rft_id=info:pmid/10567266&rft_galeid=A58038115&rft_jstor_id=2899828&rfr_iscdi=true |