Developmental and Activity-Dependent Expression of LanCL1 Confers Antioxidant Activity Required for Neuronal Survival

Production of reactive oxygen species (ROS) increases with neuronal activity that accompanies synaptic development and function. Transcription-related factors and metabolic enzymes that are expressed in all tissues have been described to counteract neuronal ROS to prevent oxidative damage. Here, we...

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Veröffentlicht in:	Developmental cell 2014-08, Vol.30 (4), p.479-487
Hauptverfasser:	Huang, Chao, Chen, Mina, Pang, Dejiang, Bi, Dandan, Zou, Yi, Xia, Xiaoqiang, Yang, Weiwei, Luo, Liping, Deng, Rongkang, Tan, Honglin, Zhou, Liang, Yu, Shouyang, Guo, Liheng, Du, XiaoXia, Cui, Yiyuan, Hu, Jiahua, Mao, Qing, Worley, Paul F., Xiao, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Brain - cytology Brain - embryology Brain - metabolism Gene Deletion Gene Expression Regulation, Developmental Mice Mice, Inbred C57BL Mitochondria - metabolism Neurons - metabolism Neurons - physiology Oxidative Stress Reactive Oxygen Species - metabolism Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism
Online-Zugang:	Volltext
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