Tetrandrine stimulates the apoptosis of hepatic stellate cells and ameliorates development of fibrosis in a thioacetamide rat model

AIM： To investigate the therapeutic effect of tetrandrine on liver fibrosis induced by thioacetamide in rats in vivo and in vitro. METHODS： In vitro study： we investigated the effect of tetrandrine on the apoptosis of rat hepatic stellate cells transformed by simian virus 40 （T-HSC/CI-6）, which reta...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2007-02, Vol.13 (8), p.1214-1220
Hauptverfasser:	Yin, Ming-Fu, Lian, Li-Hua, Piao, Dong-Ming, Nan, Ji-Xing
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - pharmacology Alkaloids - therapeutic use Animals Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use Apoptosis - drug effects Basic Research Benzylisoquinolines - pharmacology Benzylisoquinolines - therapeutic use Caspase 3 - drug effects Extracellular Matrix - metabolism Hydroxyproline - metabolism Liver - drug effects Liver - metabolism Liver - pathology Liver Cirrhosis, Experimental - drug therapy Liver Cirrhosis, Experimental - metabolism Liver Cirrhosis, Experimental - pathology Male Organ Size Rats Rats, Wistar Thioacetamide - pharmacology 硫代乙酰胺大鼠模型粉防己碱细胞凋亡肝星状细胞肝纤维化
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