Effect of parenteral and early intrajejunal nutrition on pancreatic digestive enzyme synthesis, storage and discharge in dog models of acute pancreatitis
AIM： To study the effect of early intrajejunal nutrition on enzyme-protein synthesis and secretion during acute pancreatitis. METHODS： Fifteen dogs were randomly divided into parenteral nutrition （n = 7） and early intrajejunal nutrition groups （n = 8）. An acute pancreatitis model was induced by inje...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2007-02, Vol.13 (7), p.1123-1128 |
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| creator | Qin, Huan-Long Su, Zhen-Dong Hu, Lei-Guang Ding, Zai-Xian Lin, Qing-Tian |
| description | AIM： To study the effect of early intrajejunal nutrition on enzyme-protein synthesis and secretion during acute pancreatitis. METHODS： Fifteen dogs were randomly divided into parenteral nutrition （n = 7） and early intrajejunal nutrition groups （n = 8）. An acute pancreatitis model was induced by injecting 5% sodium taurocholate and trypsin into the pancreas via the pancreatic duct. Intrajejunal nutrition was delivered with a catheter via a jejunostomy tube after the model was established for 24 h. On d 1 and 7 and at the beginning of nutritional support, radioactive tracing and electron microscopes were used to evaluate the enzyme-protein synthesis in acinar cells, the subcellular fractionation and the change in zymogen granules after 1.85 × 10^6 Bq L-3H phenylalanine was infused at 30, 60, 120, and 180 min. RESULTS： The 3H radioactivity in pancreatic acinar cells reached its peak level at 60 min, and the contents in the early intrajejunal nutrition group were higher than those in the parenteral nutrition group, which were then decreased. The mean number and area of zymogen granules did not show any significant statistical difference in both groups on d i or on d 7 （P 〉 0.05）. CONCLUSION： Early intrajejunal nutrition might be effective in dogs with acute pancreatitis. |
| doi_str_mv | 10.3748/wjg.v13.i7.1123 |
| format | Article |
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METHODS： Fifteen dogs were randomly divided into parenteral nutrition （n = 7） and early intrajejunal nutrition groups （n = 8）. An acute pancreatitis model was induced by injecting 5% sodium taurocholate and trypsin into the pancreas via the pancreatic duct. Intrajejunal nutrition was delivered with a catheter via a jejunostomy tube after the model was established for 24 h. On d 1 and 7 and at the beginning of nutritional support, radioactive tracing and electron microscopes were used to evaluate the enzyme-protein synthesis in acinar cells, the subcellular fractionation and the change in zymogen granules after 1.85 × 10^6 Bq L-3H phenylalanine was infused at 30, 60, 120, and 180 min. RESULTS： The 3H radioactivity in pancreatic acinar cells reached its peak level at 60 min, and the contents in the early intrajejunal nutrition group were higher than those in the parenteral nutrition group, which were then decreased. The mean number and area of zymogen granules did not show any significant statistical difference in both groups on d i or on d 7 （P 〉 0.05）. CONCLUSION： Early intrajejunal nutrition might be effective in dogs with acute pancreatitis.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v13.i7.1123</identifier><identifier>PMID: 17373751</identifier><language>eng</language><publisher>United States: Institute of Parenteral Nutrition and Enteral Nutrition,Department of Surgery,Shanghai Jiaotong University Affiliated Sixth People's Hospital,Yishan Rd.600,Shanghai 200233,China</publisher><subject>Acute Disease ; Amylases - metabolism ; Animals ; Cathepsin B - metabolism ; Detergents ; Disease Models, Animal ; Dogs ; Electron Transport Complex IV - metabolism ; Enteral Nutrition - methods ; Lysosomes - enzymology ; Pancreas - enzymology ; Pancreas - pathology ; Pancreas - ultrastructure ; Pancreatitis - chemically induced ; Pancreatitis - enzymology ; Pancreatitis - pathology ; Parenteral Nutrition - methods ; Rapid Communication ; Secretory Vesicles - enzymology ; Taurocholic Acid ; 动物模型 ; 肠外营养 ; 胰腺消化 ; 胰腺炎</subject><ispartof>World journal of gastroenterology : WJG, 2007-02, Vol.13 (7), p.1123-1128</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>2007 Baishideng Publishing Group Co., Limited. All rights reserved. 2007</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-7a7bb37915c15da40a002f252655edcb85966c84b2d4873aee0a54e1a292b8fd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146879/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146879/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17373751$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qin, Huan-Long</creatorcontrib><creatorcontrib>Su, Zhen-Dong</creatorcontrib><creatorcontrib>Hu, Lei-Guang</creatorcontrib><creatorcontrib>Ding, Zai-Xian</creatorcontrib><creatorcontrib>Lin, Qing-Tian</creatorcontrib><title>Effect of parenteral and early intrajejunal nutrition on pancreatic digestive enzyme synthesis, storage and discharge in dog models of acute pancreatitis</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM： To study the effect of early intrajejunal nutrition on enzyme-protein synthesis and secretion during acute pancreatitis. METHODS： Fifteen dogs were randomly divided into parenteral nutrition （n = 7） and early intrajejunal nutrition groups （n = 8）. An acute pancreatitis model was induced by injecting 5% sodium taurocholate and trypsin into the pancreas via the pancreatic duct. Intrajejunal nutrition was delivered with a catheter via a jejunostomy tube after the model was established for 24 h. On d 1 and 7 and at the beginning of nutritional support, radioactive tracing and electron microscopes were used to evaluate the enzyme-protein synthesis in acinar cells, the subcellular fractionation and the change in zymogen granules after 1.85 × 10^6 Bq L-3H phenylalanine was infused at 30, 60, 120, and 180 min. RESULTS： The 3H radioactivity in pancreatic acinar cells reached its peak level at 60 min, and the contents in the early intrajejunal nutrition group were higher than those in the parenteral nutrition group, which were then decreased. The mean number and area of zymogen granules did not show any significant statistical difference in both groups on d i or on d 7 （P 〉 0.05）. CONCLUSION： Early intrajejunal nutrition might be effective in dogs with acute pancreatitis.</description><subject>Acute Disease</subject><subject>Amylases - metabolism</subject><subject>Animals</subject><subject>Cathepsin B - metabolism</subject><subject>Detergents</subject><subject>Disease Models, Animal</subject><subject>Dogs</subject><subject>Electron Transport Complex IV - metabolism</subject><subject>Enteral Nutrition - methods</subject><subject>Lysosomes - enzymology</subject><subject>Pancreas - enzymology</subject><subject>Pancreas - pathology</subject><subject>Pancreas - ultrastructure</subject><subject>Pancreatitis - chemically induced</subject><subject>Pancreatitis - enzymology</subject><subject>Pancreatitis - pathology</subject><subject>Parenteral Nutrition - methods</subject><subject>Rapid Communication</subject><subject>Secretory Vesicles - enzymology</subject><subject>Taurocholic Acid</subject><subject>动物模型</subject><subject>肠外营养</subject><subject>胰腺消化</subject><subject>胰腺炎</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkVGP1CAQx4nReOvps2-GGB_tXoFS2hcTczm9Sy7xRZ_JlE671C6swO5l_SZ-W6m78TRDQgb-8xuGPyGvWbkWqmquHqZxfWBibdWaMS6ekBXnrC14U5VPyYqVpSpawdUFeRHjVJZcCMmfkwumRA7JVuTXzTCgSdQPdAcBXcIAMwXXU4QwH6l1KcCE097lY7dPwSbrHc1rB84EhGQN7e2IMdkDUnQ_j1uk8ejSBqON72lMPsCIf5C9jWYDIWfW0d6PdOt7nOPSHMw-4SMz2fiSPBtgjvjqvF-Sb59uvl7fFvdfPt9df7wvjGQiFQpU1wnVMmmY7KEqIY85cMlrKbE3XSPbujZN1fG-apQAxBJkhQx4y7tm6MUl-XDi7vbdNlfgMvGsd8FuIRy1B6v_v3F2o0d_0BWr6ka1GfDuBHgAN4Ab9eT3IX9X1Nkdni3IwXmWXZ1kJvgYAw5_W7BSL2Yucp3N1Fbpxcxc8ebflz3qz-5lwdszcuPd-MPm3h2Y74OdUfOKcV7JWvwGkLGsNg</recordid><startdate>20070221</startdate><enddate>20070221</enddate><creator>Qin, Huan-Long</creator><creator>Su, Zhen-Dong</creator><creator>Hu, Lei-Guang</creator><creator>Ding, Zai-Xian</creator><creator>Lin, Qing-Tian</creator><general>Institute of Parenteral Nutrition and Enteral Nutrition,Department of Surgery,Shanghai Jiaotong University Affiliated Sixth People's Hospital,Yishan Rd.600,Shanghai 200233,China</general><general>Baishideng Publishing Group Co., Limited</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20070221</creationdate><title>Effect of parenteral and early intrajejunal nutrition on pancreatic digestive enzyme synthesis, storage and discharge in dog models of acute pancreatitis</title><author>Qin, Huan-Long ; Su, Zhen-Dong ; Hu, Lei-Guang ; Ding, Zai-Xian ; Lin, Qing-Tian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-7a7bb37915c15da40a002f252655edcb85966c84b2d4873aee0a54e1a292b8fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Acute Disease</topic><topic>Amylases - metabolism</topic><topic>Animals</topic><topic>Cathepsin B - metabolism</topic><topic>Detergents</topic><topic>Disease Models, Animal</topic><topic>Dogs</topic><topic>Electron Transport Complex IV - metabolism</topic><topic>Enteral Nutrition - methods</topic><topic>Lysosomes - enzymology</topic><topic>Pancreas - enzymology</topic><topic>Pancreas - pathology</topic><topic>Pancreas - ultrastructure</topic><topic>Pancreatitis - chemically induced</topic><topic>Pancreatitis - enzymology</topic><topic>Pancreatitis - pathology</topic><topic>Parenteral Nutrition - methods</topic><topic>Rapid Communication</topic><topic>Secretory Vesicles - enzymology</topic><topic>Taurocholic Acid</topic><topic>动物模型</topic><topic>肠外营养</topic><topic>胰腺消化</topic><topic>胰腺炎</topic><toplevel>online_resources</toplevel><creatorcontrib>Qin, Huan-Long</creatorcontrib><creatorcontrib>Su, Zhen-Dong</creatorcontrib><creatorcontrib>Hu, Lei-Guang</creatorcontrib><creatorcontrib>Ding, Zai-Xian</creatorcontrib><creatorcontrib>Lin, Qing-Tian</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qin, Huan-Long</au><au>Su, Zhen-Dong</au><au>Hu, Lei-Guang</au><au>Ding, Zai-Xian</au><au>Lin, Qing-Tian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of parenteral and early intrajejunal nutrition on pancreatic digestive enzyme synthesis, storage and discharge in dog models of acute pancreatitis</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2007-02-21</date><risdate>2007</risdate><volume>13</volume><issue>7</issue><spage>1123</spage><epage>1128</epage><pages>1123-1128</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM： To study the effect of early intrajejunal nutrition on enzyme-protein synthesis and secretion during acute pancreatitis. METHODS： Fifteen dogs were randomly divided into parenteral nutrition （n = 7） and early intrajejunal nutrition groups （n = 8）. An acute pancreatitis model was induced by injecting 5% sodium taurocholate and trypsin into the pancreas via the pancreatic duct. Intrajejunal nutrition was delivered with a catheter via a jejunostomy tube after the model was established for 24 h. On d 1 and 7 and at the beginning of nutritional support, radioactive tracing and electron microscopes were used to evaluate the enzyme-protein synthesis in acinar cells, the subcellular fractionation and the change in zymogen granules after 1.85 × 10^6 Bq L-3H phenylalanine was infused at 30, 60, 120, and 180 min. RESULTS： The 3H radioactivity in pancreatic acinar cells reached its peak level at 60 min, and the contents in the early intrajejunal nutrition group were higher than those in the parenteral nutrition group, which were then decreased. The mean number and area of zymogen granules did not show any significant statistical difference in both groups on d i or on d 7 （P 〉 0.05）. CONCLUSION： Early intrajejunal nutrition might be effective in dogs with acute pancreatitis.</abstract><cop>United States</cop><pub>Institute of Parenteral Nutrition and Enteral Nutrition,Department of Surgery,Shanghai Jiaotong University Affiliated Sixth People's Hospital,Yishan Rd.600,Shanghai 200233,China</pub><pmid>17373751</pmid><doi>10.3748/wjg.v13.i7.1123</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | World journal of gastroenterology : WJG, 2007-02, Vol.13 (7), p.1123-1128 |
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| source | MEDLINE; PubMed Central; Alma/SFX Local Collection |
| subjects | Acute Disease Amylases - metabolism Animals Cathepsin B - metabolism Detergents Disease Models, Animal Dogs Electron Transport Complex IV - metabolism Enteral Nutrition - methods Lysosomes - enzymology Pancreas - enzymology Pancreas - pathology Pancreas - ultrastructure Pancreatitis - chemically induced Pancreatitis - enzymology Pancreatitis - pathology Parenteral Nutrition - methods Rapid Communication Secretory Vesicles - enzymology Taurocholic Acid 动物模型 肠外营养 胰腺消化 胰腺炎 |
| title | Effect of parenteral and early intrajejunal nutrition on pancreatic digestive enzyme synthesis, storage and discharge in dog models of acute pancreatitis |
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