Elevated HERV-K mRNA expression in PBMC is associated with a prostate cancer diagnosis particularly in older men and smokers

Aberrant expression of subgroup k human endogenous retroviruses (HERV-K) has been observed in prostate cancer. This subgroup is unique because it encodes sequences in the human genome containing open reading frames for near intact retroviruses. We hypothesized that HERV-K reactivation could serve as...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Carcinogenesis (New York) 2014-09, Vol.35 (9), p.2074-2083
Hauptverfasser:	Wallace, Tiffany A, Downey, Ronan F, Seufert, Caleb J, Schetter, Aaron, Dorsey, Tiffany H, Johnson, Carol A, Goldman, Radoslav, Loffredo, Christopher A, Yan, Peisha, Sullivan, Francis J, Giles, Francis J, Wang-Johanning, Feng, Ambs, Stefan, Glynn, Sharon A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - blood Adenocarcinoma - diagnosis Adenocarcinoma - virology Chemokine CXCL10 - blood Endogenous Retroviruses - enzymology Gene Expression Gene Products, gag - blood Humans Interferon-gamma - blood Leukocytes, Mononuclear - metabolism Leukocytes, Mononuclear - virology Male Original Manuscript Prostatic Neoplasms - blood Prostatic Neoplasms - diagnosis Prostatic Neoplasms - virology Risk Factors RNA, Messenger - blood RNA, Messenger - genetics Smoking - blood
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!