Upregulation of NHE1 protein expression enables glioblastoma cells to escape TMZ-mediated toxicity via increased H⁺ extrusion, cell migration and survival

Sodium-hydrogen exchanger isoform 1 (NHE1) plays a role in survival and migration/invasion of several cancers and is an emerging new therapeutic target. However, the role of NHE1 in glioblastoma and the interaction of NHE1 expression and function in glioblastoma cells with cytotoxic temozolomide (TM...

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Veröffentlicht in:	Carcinogenesis (New York) 2014-09, Vol.35 (9), p.2014-2024
Hauptverfasser:	Cong, Damin, Zhu, Wen, Shi, Yejie, Pointer, Kelli B, Clark, Paul A, Shen, Hongmei, Kuo, John S, Hu, Shaoshan, Sun, Dandan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid-Base Equilibrium Animals Antineoplastic Agents, Alkylating - pharmacology Apoptosis Astrocytes - metabolism Biological Transport Cation Transport Proteins - genetics Cation Transport Proteins - metabolism Cell Line, Tumor Cell Movement Cell Survival Dacarbazine - analogs & derivatives Dacarbazine - pharmacology Drug Resistance, Neoplasm Enzyme Activation Extracellular Signal-Regulated MAP Kinases - metabolism Gene Expression Regulation, Neoplastic - drug effects Glioblastoma Humans MAP Kinase Signaling System Mice Neural Stem Cells - metabolism Original Manuscript Sodium-Hydrogen Exchanger 1 Sodium-Hydrogen Exchangers - genetics Sodium-Hydrogen Exchangers - metabolism Up-Regulation
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