The Influence of TRP53 in the Dose Response of Radiation-Induced Apoptosis, DNA Repair and Genomic Stability in Murine Haematopoietic Cells

Apoptotic and DNA damage endpoints are frequently used as surrogate markers of cancer risk, and have been well-studied in the Trp53+/− mouse model. We report the effect of differing Trp53 gene status on the dose response of ionizing radiation exposures (0.01–2 Gy), with the unique perspective of det...

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Veröffentlicht in:	Dose-response 2014-07, Vol.12 (3), p.365-385
Hauptverfasser:	Lemon, Jennifer A., Taylor, Kristina, Verdecchia, Kyle, Phan, Nghi, Boreham, Douglas R.
Format:	Artikel
Sprache:	eng
Schlagworte:	apoptosis BASIC BIOLOGICAL SCIENCES cell cycle arrest DNA damage ionizing radiation RADIOLOGY AND NUCLEAR MEDICINE Trp53
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