Dab2 attenuates brain injury in APP/PS1 mice via targeting transforming growth factor-beta/SMAD signaling

Transforming growth factor-beta （TGF-β） type II receptor （TβRⅡ） levels are extremely low in the brain tissue of patients with Alzheimer＇s disease. This receptor inhibits TGF-β1/SMAD signaling and thereby aggravates amyolid-beta deposition and neuronal injury. Dab2, a specific adapter protein, protec...

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Veröffentlicht in:	Neural regeneration research 2014, Vol.9 (1), p.41-50
Hauptverfasser:	Song, Lei, Gu, Yue, Jie, Jing, Bai, Xiaoxue, Yang, Ying, Liu, Chaoying, Liu, Qun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adapter proteins Age Alzheimer's disease Amyloid beta-protein Cytokines Development and progression Disease Genetic aspects Growth factors Health aspects MicroRNAs Nervous system Neurons Neurotoxicity Phosphorylation Plasmids Research and Report Rodents Signal transduction TGF-β Transforming growth factors Transgenic animals Traumatic brain injury Tumor necrosis factor-TNF 信号衰减小鼠模型神经保护作用肿瘤坏死因子-α 脑损伤转化生长因子-β 阿尔茨海默氏病
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