Mannotriose regulates learning and memory signal transduction in the hippocampus
Rehmannia is a commonly used Chinese herb, which improves ieaming and memory. However, the crucial components of the signal transduction pathway associated with this effect remain elusive. Pri- mary hippocampal neurons were cultured in vitro, insulted with high-concentration （1 × 10-4 mol/L） cor- ti...
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| Veröffentlicht in: | Neural regeneration research 2013-11, Vol.8 (32), p.3020-3026 |
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| creator | Zhang, Lina Dai, Weiwei Zhang, Xueli Gong, Zhangbin Jin, Guoqin |
| description | Rehmannia is a commonly used Chinese herb, which improves ieaming and memory. However, the crucial components of the signal transduction pathway associated with this effect remain elusive. Pri- mary hippocampal neurons were cultured in vitro, insulted with high-concentration （1 × 10-4 mol/L） cor- ticosterone, and treated with 1 × 104 mol/L mannotriose. Thiazolyl blue tetrazolium bromide assay and western blot analysis showed that hippocampal neuron survival rates and protein levels of glucocorti- cold receptor, serum and glucocorticoid-regulated protein kinase, and brain-derived neurotrophic factor were all dramatically decreased after high-concentration corticosterone-induced injury. This effect was reversed by mannotriose, to a similar level as RU38486 and donepezil. Our findings indicate that mannotriose could protect hippocampal neurons from high-concentration corticosterone-induced injury. The mechanism by which this occurred was associated with levels of glucocorticoid receptor protein, serum and glucocorticoid-regulated protein kinase, and brain-derived neurotrophic factor. |
| doi_str_mv | 10.3969/j.issn.1673-5374.2013.32.005 |
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However, the crucial components of the signal transduction pathway associated with this effect remain elusive. Pri- mary hippocampal neurons were cultured in vitro, insulted with high-concentration （1 × 10-4 mol/L） cor- ticosterone, and treated with 1 × 104 mol/L mannotriose. Thiazolyl blue tetrazolium bromide assay and western blot analysis showed that hippocampal neuron survival rates and protein levels of glucocorti- cold receptor, serum and glucocorticoid-regulated protein kinase, and brain-derived neurotrophic factor were all dramatically decreased after high-concentration corticosterone-induced injury. This effect was reversed by mannotriose, to a similar level as RU38486 and donepezil. Our findings indicate that mannotriose could protect hippocampal neurons from high-concentration corticosterone-induced injury. The mechanism by which this occurred was associated with levels of glucocorticoid receptor protein, serum and glucocorticoid-regulated protein kinase, and brain-derived neurotrophic factor.</description><identifier>ISSN: 1673-5374</identifier><identifier>EISSN: 1876-7958</identifier><identifier>DOI: 10.3969/j.issn.1673-5374.2013.32.005</identifier><identifier>PMID: 25206622</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>Cellular signal transduction ; Gene expression ; Hippocampus (Brain) ; Learning ; Memory ; Physiological aspects ; Research and Report : Cognitive and Neural Regeneration ; 三糖 ; 信号转导途径 ; 免疫印迹分析 ; 学习 ; 海马神经元 ; 脑源性神经营养因子 ; 蛋白水平 ; 记忆</subject><ispartof>Neural regeneration research, 2013-11, Vol.8 (32), p.3020-3026</ispartof><rights>COPYRIGHT 2013 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>Copyright: © Neural Regeneration Research 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/88507X/88507X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146209/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146209/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25206622$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Lina</creatorcontrib><creatorcontrib>Dai, Weiwei</creatorcontrib><creatorcontrib>Zhang, Xueli</creatorcontrib><creatorcontrib>Gong, Zhangbin</creatorcontrib><creatorcontrib>Jin, Guoqin</creatorcontrib><title>Mannotriose regulates learning and memory signal transduction in the hippocampus</title><title>Neural regeneration research</title><addtitle>Neural Regeneration Research</addtitle><description>Rehmannia is a commonly used Chinese herb, which improves ieaming and memory. However, the crucial components of the signal transduction pathway associated with this effect remain elusive. Pri- mary hippocampal neurons were cultured in vitro, insulted with high-concentration （1 × 10-4 mol/L） cor- ticosterone, and treated with 1 × 104 mol/L mannotriose. Thiazolyl blue tetrazolium bromide assay and western blot analysis showed that hippocampal neuron survival rates and protein levels of glucocorti- cold receptor, serum and glucocorticoid-regulated protein kinase, and brain-derived neurotrophic factor were all dramatically decreased after high-concentration corticosterone-induced injury. This effect was reversed by mannotriose, to a similar level as RU38486 and donepezil. Our findings indicate that mannotriose could protect hippocampal neurons from high-concentration corticosterone-induced injury. The mechanism by which this occurred was associated with levels of glucocorticoid receptor protein, serum and glucocorticoid-regulated protein kinase, and brain-derived neurotrophic factor.</description><subject>Cellular signal transduction</subject><subject>Gene expression</subject><subject>Hippocampus (Brain)</subject><subject>Learning</subject><subject>Memory</subject><subject>Physiological aspects</subject><subject>Research and Report : Cognitive and Neural Regeneration</subject><subject>三糖</subject><subject>信号转导途径</subject><subject>免疫印迹分析</subject><subject>学习</subject><subject>海马神经元</subject><subject>脑源性神经营养因子</subject><subject>蛋白水平</subject><subject>记忆</subject><issn>1673-5374</issn><issn>1876-7958</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNptkd1r1jAUxosobk7_BanohSCt-WySG2EMv2CiF3od8iYnfVPapGta5d1fb8a7DQeSi4ScX56c5zlV9QajlqpOvR_akHNscSdow6lgLUGYtpS0CPFH1SmWomuE4vJxOd8xJ9WznIcCSEXo0-qEcIK6jpDT6sc3E2Nal5Ay1Av022hWyPUIZokh9rWJrp5gSsuhzqGPZqzXxcTsNruGFOsQ63UP9T7Mc7Jmmrf8vHrizZjhxe1-Vv369PHnxZfm8vvnrxfnl42liq-No556QZnYYb6TwnkkGN4RoaSTSCFhhXWeKuo774yyHAQzDoNHFMAo6OhZ9eGoO2-7CZyFWBob9byEySwHnUzQDysx7HWffmuGWUeQKgLvjgJ_TPQm9npI21IMZn3d5-E6HwYNN9FSUnIr9Nvb75Z0tUFe9RSyhXE0EdKWNeZd0eVckoK-PqK9GUGH6Eu8xt7g-pxKygVighWq_Q9VloMp2BTBh3L_4MHLfw3fO72bZQFeHQG7T7G_KtO7Z5hEmCEk6V-XprCK</recordid><startdate>20131115</startdate><enddate>20131115</enddate><creator>Zhang, Lina</creator><creator>Dai, Weiwei</creator><creator>Zhang, Xueli</creator><creator>Gong, Zhangbin</creator><creator>Jin, Guoqin</creator><general>Medknow Publications and Media Pvt. Ltd</general><general>Department of Biochemistry, Institute of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China</general><general>Medknow Publications & Media Pvt Ltd</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>NPM</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20131115</creationdate><title>Mannotriose regulates learning and memory signal transduction in the hippocampus</title><author>Zhang, Lina ; Dai, Weiwei ; Zhang, Xueli ; Gong, Zhangbin ; Jin, Guoqin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-d3f3f7347b15b87df0741b2798d80907c7cdf393f6fda9c5e74ad1ef03eea9e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Cellular signal transduction</topic><topic>Gene expression</topic><topic>Hippocampus (Brain)</topic><topic>Learning</topic><topic>Memory</topic><topic>Physiological aspects</topic><topic>Research and Report : Cognitive and Neural Regeneration</topic><topic>三糖</topic><topic>信号转导途径</topic><topic>免疫印迹分析</topic><topic>学习</topic><topic>海马神经元</topic><topic>脑源性神经营养因子</topic><topic>蛋白水平</topic><topic>记忆</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Lina</creatorcontrib><creatorcontrib>Dai, Weiwei</creatorcontrib><creatorcontrib>Zhang, Xueli</creatorcontrib><creatorcontrib>Gong, Zhangbin</creatorcontrib><creatorcontrib>Jin, Guoqin</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neural regeneration research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Lina</au><au>Dai, Weiwei</au><au>Zhang, Xueli</au><au>Gong, Zhangbin</au><au>Jin, Guoqin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mannotriose regulates learning and memory signal transduction in the hippocampus</atitle><jtitle>Neural regeneration research</jtitle><addtitle>Neural Regeneration Research</addtitle><date>2013-11-15</date><risdate>2013</risdate><volume>8</volume><issue>32</issue><spage>3020</spage><epage>3026</epage><pages>3020-3026</pages><issn>1673-5374</issn><eissn>1876-7958</eissn><abstract>Rehmannia is a commonly used Chinese herb, which improves ieaming and memory. However, the crucial components of the signal transduction pathway associated with this effect remain elusive. Pri- mary hippocampal neurons were cultured in vitro, insulted with high-concentration （1 × 10-4 mol/L） cor- ticosterone, and treated with 1 × 104 mol/L mannotriose. Thiazolyl blue tetrazolium bromide assay and western blot analysis showed that hippocampal neuron survival rates and protein levels of glucocorti- cold receptor, serum and glucocorticoid-regulated protein kinase, and brain-derived neurotrophic factor were all dramatically decreased after high-concentration corticosterone-induced injury. This effect was reversed by mannotriose, to a similar level as RU38486 and donepezil. Our findings indicate that mannotriose could protect hippocampal neurons from high-concentration corticosterone-induced injury. The mechanism by which this occurred was associated with levels of glucocorticoid receptor protein, serum and glucocorticoid-regulated protein kinase, and brain-derived neurotrophic factor.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>25206622</pmid><doi>10.3969/j.issn.1673-5374.2013.32.005</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Medknow Open Access Medical Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; Journals@Ovid Complete; PubMed Central Open Access |
| subjects | Cellular signal transduction Gene expression Hippocampus (Brain) Learning Memory Physiological aspects Research and Report : Cognitive and Neural Regeneration 三糖 信号转导途径 免疫印迹分析 学习 海马神经元 脑源性神经营养因子 蛋白水平 记忆 |
| title | Mannotriose regulates learning and memory signal transduction in the hippocampus |
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