Shuyusan-containing serum protects SH-SY5Y cells against corticosterone-induced impairment
The Chinese herb Shuyusan, whose main constituent is jasminoidin, has been shown to protect SH-SY5Y cells against corticosterone-induced damage. SH-SY5Y cells injured by 400 μmol/L cor- ticosterone were treated with 5 and 30 μg/mL Shuyusan-containing serum. Results revealed that Shuyusan-containing...
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| Veröffentlicht in: | Neural regeneration research 2013-08, Vol.8 (22), p.2060-2068 |
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| creator | Chen, Liping Sun, Zhigao Wang, Fawei Xu, Chengyong Geng, Miao Chen, Hongyan Duan, Dongmei |
| description | The Chinese herb Shuyusan, whose main constituent is jasminoidin, has been shown to protect SH-SY5Y cells against corticosterone-induced damage. SH-SY5Y cells injured by 400 μmol/L cor- ticosterone were treated with 5 and 30 μg/mL Shuyusan-containing serum. Results revealed that Shuyusan-containing serum elevated the survival rate of SH-SY5Y cells, reduced Bax expression, increased Bcl-2 expression, markedly elevated brain-derived neurotrophic factor mRNA expression, and blocked cell apoptosis. Moreover, the effect of high-dose （30 μg/mL） Shuyusan-containing se- rum was more remarkable. Therefore, Shuyusan-containing serum appears to protect SH-SY5Y cells against corticosterone-induced impairment by adjusting the expression of apoptosis-associ- ated proteins and brain-derived neurotrophic factor. Moreover, high-dose Shuyusan-containing se- rum has a protective effect on high-dose corticosterone-induced impairment. |
| doi_str_mv | 10.3969/j.issn.1673-5374.2013.22.005 |
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SH-SY5Y cells injured by 400 μmol/L cor- ticosterone were treated with 5 and 30 μg/mL Shuyusan-containing serum. Results revealed that Shuyusan-containing serum elevated the survival rate of SH-SY5Y cells, reduced Bax expression, increased Bcl-2 expression, markedly elevated brain-derived neurotrophic factor mRNA expression, and blocked cell apoptosis. Moreover, the effect of high-dose （30 μg/mL） Shuyusan-containing se- rum was more remarkable. Therefore, Shuyusan-containing serum appears to protect SH-SY5Y cells against corticosterone-induced impairment by adjusting the expression of apoptosis-associ- ated proteins and brain-derived neurotrophic factor. Moreover, high-dose Shuyusan-containing se- rum has a protective effect on high-dose corticosterone-induced impairment.</description><identifier>ISSN: 1673-5374</identifier><identifier>EISSN: 1876-7958</identifier><identifier>DOI: 10.3969/j.issn.1673-5374.2013.22.005</identifier><identifier>PMID: 25206514</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>Antidepressants ; Apoptosis ; Brain ; Brain-derived neurotrophic factor ; Corticosterone ; Drug dosages ; Mental depression ; mRNA表达 ; Nervous system ; Pathogenesis ; Protein expression ; Proteins ; Recipes ; Research and Report : Traditional Chinese Medicine and Neural Regeneration ; RNA ; SH-SY5Y细胞 ; Steroids ; Studies ; 保护作用 ; 皮质酮 ; 细胞损伤 ; 脑源性神经营养因子 ; 血清 ; 诱导</subject><ispartof>Neural regeneration research, 2013-08, Vol.8 (22), p.2060-2068</ispartof><rights>COPYRIGHT 2013 Medknow Publications and Media Pvt. Ltd.</rights><rights>2013. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>Copyright: © Neural Regeneration Research 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-bedd4cde8539d9f1c60f5ff4b0cb7f121f46e3981a99fc4f0f9a1436d4e95b383</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/88507X/88507X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146065/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146065/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25206514$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Liping</creatorcontrib><creatorcontrib>Sun, Zhigao</creatorcontrib><creatorcontrib>Wang, Fawei</creatorcontrib><creatorcontrib>Xu, Chengyong</creatorcontrib><creatorcontrib>Geng, Miao</creatorcontrib><creatorcontrib>Chen, Hongyan</creatorcontrib><creatorcontrib>Duan, Dongmei</creatorcontrib><title>Shuyusan-containing serum protects SH-SY5Y cells against corticosterone-induced impairment</title><title>Neural regeneration research</title><addtitle>Neural Regeneration Research</addtitle><description>The Chinese herb Shuyusan, whose main constituent is jasminoidin, has been shown to protect SH-SY5Y cells against corticosterone-induced damage. SH-SY5Y cells injured by 400 μmol/L cor- ticosterone were treated with 5 and 30 μg/mL Shuyusan-containing serum. Results revealed that Shuyusan-containing serum elevated the survival rate of SH-SY5Y cells, reduced Bax expression, increased Bcl-2 expression, markedly elevated brain-derived neurotrophic factor mRNA expression, and blocked cell apoptosis. Moreover, the effect of high-dose （30 μg/mL） Shuyusan-containing se- rum was more remarkable. Therefore, Shuyusan-containing serum appears to protect SH-SY5Y cells against corticosterone-induced impairment by adjusting the expression of apoptosis-associ- ated proteins and brain-derived neurotrophic factor. Moreover, high-dose Shuyusan-containing se- rum has a protective effect on high-dose corticosterone-induced impairment.</description><subject>Antidepressants</subject><subject>Apoptosis</subject><subject>Brain</subject><subject>Brain-derived neurotrophic factor</subject><subject>Corticosterone</subject><subject>Drug dosages</subject><subject>Mental depression</subject><subject>mRNA表达</subject><subject>Nervous system</subject><subject>Pathogenesis</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Recipes</subject><subject>Research and Report : Traditional Chinese Medicine and Neural Regeneration</subject><subject>RNA</subject><subject>SH-SY5Y细胞</subject><subject>Steroids</subject><subject>Studies</subject><subject>保护作用</subject><subject>皮质酮</subject><subject>细胞损伤</subject><subject>脑源性神经营养因子</subject><subject>血清</subject><subject>诱导</subject><issn>1673-5374</issn><issn>1876-7958</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkc1u1DAUhSMEoqXwCigIFkgowf-ON0hVBRSpEouBRdlYjmNnHCX21E5aTZ8ej6YdWlR5Yev687nX5xTFBwhqLJj4PNQuJV9DxnFFMSc1AhDXCNUA0GfFMWw4q7igzfN8vmeOilcpDRloBMIviyNEEWAUkuPiz2q9bJekfKWDn5XzzvdlMnGZyk0Ms9FzKlfn1eqSXpbajGMqVZ-pNJc6xNnpkGYTgzeV892iTVe6aaNcnIyfXxcvrBqTeXO3nxS_v339dXZeXfz8_uPs9KLSpEFz1ZquI7ozDcWiExZqBiy1lrRAt9xCBC1hBosGKiGsJhZYoSDBrCNG0BY3-KT4stfdLO1kOp1bRzXKTXSTilsZlJOPb7xbyz5cSwIJyzZkgU97gRvlrfK9HMISfR5Z3vZpuE3bQZqdyQhlBzP98a5dDFeLSbOcXNpZo7wJS5KQsqxLKcAZff8felBGuEG8ARCif1SvRiOdtyFPqXei8jR_j3KABMxU_QSVV2emHIM31uX6owdvH9py8OM--wy82wN6HXx_lYM_MIQDzhkj-C8IIL_X</recordid><startdate>20130805</startdate><enddate>20130805</enddate><creator>Chen, Liping</creator><creator>Sun, Zhigao</creator><creator>Wang, Fawei</creator><creator>Xu, Chengyong</creator><creator>Geng, Miao</creator><creator>Chen, Hongyan</creator><creator>Duan, Dongmei</creator><general>Medknow Publications and Media Pvt. Ltd</general><general>Medknow Publications & Media Pvt. Ltd</general><general>Department of Traditional Chinese Medicine, Hainan Branch of Chinese PLA General Hospital, Sanya 572004, Hainan Province, China%Department of Internal Medicine, Hainan Branch of Chinese PLA General Hospital, Sanya 572004, Hainan Province, China%Institute of Geriatrics, General Hospital of Chinese PLA, Beijing 100853, China</general><general>Medknow Publications & Media Pvt Ltd</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M2M</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20130805</creationdate><title>Shuyusan-containing serum protects SH-SY5Y cells against corticosterone-induced impairment</title><author>Chen, Liping ; Sun, Zhigao ; Wang, Fawei ; Xu, Chengyong ; Geng, Miao ; Chen, Hongyan ; Duan, Dongmei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-bedd4cde8539d9f1c60f5ff4b0cb7f121f46e3981a99fc4f0f9a1436d4e95b383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Antidepressants</topic><topic>Apoptosis</topic><topic>Brain</topic><topic>Brain-derived neurotrophic factor</topic><topic>Corticosterone</topic><topic>Drug dosages</topic><topic>Mental depression</topic><topic>mRNA表达</topic><topic>Nervous system</topic><topic>Pathogenesis</topic><topic>Protein expression</topic><topic>Proteins</topic><topic>Recipes</topic><topic>Research and Report : Traditional Chinese Medicine and Neural Regeneration</topic><topic>RNA</topic><topic>SH-SY5Y细胞</topic><topic>Steroids</topic><topic>Studies</topic><topic>保护作用</topic><topic>皮质酮</topic><topic>细胞损伤</topic><topic>脑源性神经营养因子</topic><topic>血清</topic><topic>诱导</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Liping</creatorcontrib><creatorcontrib>Sun, Zhigao</creatorcontrib><creatorcontrib>Wang, Fawei</creatorcontrib><creatorcontrib>Xu, Chengyong</creatorcontrib><creatorcontrib>Geng, Miao</creatorcontrib><creatorcontrib>Chen, Hongyan</creatorcontrib><creatorcontrib>Duan, Dongmei</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Psychology</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neural regeneration research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Liping</au><au>Sun, Zhigao</au><au>Wang, Fawei</au><au>Xu, Chengyong</au><au>Geng, Miao</au><au>Chen, Hongyan</au><au>Duan, Dongmei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Shuyusan-containing serum protects SH-SY5Y cells against corticosterone-induced impairment</atitle><jtitle>Neural regeneration research</jtitle><addtitle>Neural Regeneration Research</addtitle><date>2013-08-05</date><risdate>2013</risdate><volume>8</volume><issue>22</issue><spage>2060</spage><epage>2068</epage><pages>2060-2068</pages><issn>1673-5374</issn><eissn>1876-7958</eissn><abstract>The Chinese herb Shuyusan, whose main constituent is jasminoidin, has been shown to protect SH-SY5Y cells against corticosterone-induced damage. SH-SY5Y cells injured by 400 μmol/L cor- ticosterone were treated with 5 and 30 μg/mL Shuyusan-containing serum. Results revealed that Shuyusan-containing serum elevated the survival rate of SH-SY5Y cells, reduced Bax expression, increased Bcl-2 expression, markedly elevated brain-derived neurotrophic factor mRNA expression, and blocked cell apoptosis. Moreover, the effect of high-dose （30 μg/mL） Shuyusan-containing se- rum was more remarkable. Therefore, Shuyusan-containing serum appears to protect SH-SY5Y cells against corticosterone-induced impairment by adjusting the expression of apoptosis-associ- ated proteins and brain-derived neurotrophic factor. Moreover, high-dose Shuyusan-containing se- rum has a protective effect on high-dose corticosterone-induced impairment.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>25206514</pmid><doi>10.3969/j.issn.1673-5374.2013.22.005</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | Medknow Open Access Medical Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; Journals@Ovid Complete; PubMed Central Open Access |
| subjects | Antidepressants Apoptosis Brain Brain-derived neurotrophic factor Corticosterone Drug dosages Mental depression mRNA表达 Nervous system Pathogenesis Protein expression Proteins Recipes Research and Report : Traditional Chinese Medicine and Neural Regeneration RNA SH-SY5Y细胞 Steroids Studies 保护作用 皮质酮 细胞损伤 脑源性神经营养因子 血清 诱导 |
| title | Shuyusan-containing serum protects SH-SY5Y cells against corticosterone-induced impairment |
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