Blood-letting punctures at twelve Jing-Well points of the hand can treat cerebral ischemia in a similar manner to mannitol
A rat model of middle cerebral artery permanent occlusion was established using the modified Longa method. Successfully established model animals were treated by blood-letting puncture at twelve Jing-Well points of the hand, and/or by injecting mannitol into the caudal vein twice daily. Brain tissue...
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| Veröffentlicht in: | Neural regeneration research 2013-02, Vol.8 (6), p.532-539 |
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| creator | Lu, Xuan Chen, Zelin Guo, Yi Gao, Liang Jiang, Liyuan Li, Zhongzheng Fang, Jianqiao |
| description | A rat model of middle cerebral artery permanent occlusion was established using the modified Longa method. Successfully established model animals were treated by blood-letting puncture at twelve Jing-Well points of the hand, and/or by injecting mannitol into the caudal vein twice daily. Brain tissue was collected at 24, 48 and 72 hours after modeling, and blood was collected through the retinal vein before Evans blue was injected, approximately 1 hour prior to harvesting of brain tissue. Results showed that Evans blue leakage into brain tissue and serum nitric oxide synthase activity were significantly increased in model rats. Treatment with blood-letting punctures at twelve Jing-Well points of the hand and/or injection of mannitol into the caudal vein reduced the amount of Evans blue leakage into the brain tissue and serum nitric oxide synthase activity to varying degrees. There was no significant difference between single treatment and combined treatment. Experimental findings indicate that blood-letting punctures at twelve Jing-Well points of the hand can decrease blood-brain barrier permeability and serum nitric oxide synthase activity in rats following middle cerebral artery occlusion, and its effect is similar to that of mannitol injection alone and Jing-Well points plus mannitol injection. |
| doi_str_mv | 10.3969/j.issn.1673-5374.2013.06.006 |
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Successfully established model animals were treated by blood-letting puncture at twelve Jing-Well points of the hand, and/or by injecting mannitol into the caudal vein twice daily. Brain tissue was collected at 24, 48 and 72 hours after modeling, and blood was collected through the retinal vein before Evans blue was injected, approximately 1 hour prior to harvesting of brain tissue. Results showed that Evans blue leakage into brain tissue and serum nitric oxide synthase activity were significantly increased in model rats. Treatment with blood-letting punctures at twelve Jing-Well points of the hand and/or injection of mannitol into the caudal vein reduced the amount of Evans blue leakage into the brain tissue and serum nitric oxide synthase activity to varying degrees. There was no significant difference between single treatment and combined treatment. Experimental findings indicate that blood-letting punctures at twelve Jing-Well points of the hand can decrease blood-brain barrier permeability and serum nitric oxide synthase activity in rats following middle cerebral artery occlusion, and its effect is similar to that of mannitol injection alone and Jing-Well points plus mannitol injection.</description><identifier>ISSN: 1673-5374</identifier><identifier>EISSN: 1876-7958</identifier><identifier>DOI: 10.3969/j.issn.1673-5374.2013.06.006</identifier><identifier>PMID: 25206696</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>Acupuncture ; Acupuncture and Moxibustion and Neural Regeneration ; Animal experimentation ; Biosynthesis ; Blood-brain barrier ; Brain ; Care and treatment ; Cerebral ischemia ; Chinese medicine ; Edema ; Enzymes ; Health aspects ; Ischemia ; Mannitol ; Nitric oxide ; Permeability ; Stroke ; Studies ; Veins & arteries ; 一氧化氮合成酶 ; 动物模型 ; 放血 ; 甘露醇注射液 ; 穿刺治疗 ; 类似 ; 脑缺血 ; 静脉注射</subject><ispartof>Neural regeneration research, 2013-02, Vol.8 (6), p.532-539</ispartof><rights>COPYRIGHT 2013 Medknow Publications and Media Pvt. Ltd.</rights><rights>2013. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright: © Neural Regeneration Research 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/88507X/88507X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146051/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146051/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25206696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lu, Xuan</creatorcontrib><creatorcontrib>Chen, Zelin</creatorcontrib><creatorcontrib>Guo, Yi</creatorcontrib><creatorcontrib>Gao, Liang</creatorcontrib><creatorcontrib>Jiang, Liyuan</creatorcontrib><creatorcontrib>Li, Zhongzheng</creatorcontrib><creatorcontrib>Fang, Jianqiao</creatorcontrib><title>Blood-letting punctures at twelve Jing-Well points of the hand can treat cerebral ischemia in a similar manner to mannitol</title><title>Neural regeneration research</title><addtitle>Neural Regeneration Research</addtitle><description>A rat model of middle cerebral artery permanent occlusion was established using the modified Longa method. Successfully established model animals were treated by blood-letting puncture at twelve Jing-Well points of the hand, and/or by injecting mannitol into the caudal vein twice daily. Brain tissue was collected at 24, 48 and 72 hours after modeling, and blood was collected through the retinal vein before Evans blue was injected, approximately 1 hour prior to harvesting of brain tissue. Results showed that Evans blue leakage into brain tissue and serum nitric oxide synthase activity were significantly increased in model rats. Treatment with blood-letting punctures at twelve Jing-Well points of the hand and/or injection of mannitol into the caudal vein reduced the amount of Evans blue leakage into the brain tissue and serum nitric oxide synthase activity to varying degrees. There was no significant difference between single treatment and combined treatment. Experimental findings indicate that blood-letting punctures at twelve Jing-Well points of the hand can decrease blood-brain barrier permeability and serum nitric oxide synthase activity in rats following middle cerebral artery occlusion, and its effect is similar to that of mannitol injection alone and Jing-Well points plus mannitol injection.</description><subject>Acupuncture</subject><subject>Acupuncture and Moxibustion and Neural Regeneration</subject><subject>Animal experimentation</subject><subject>Biosynthesis</subject><subject>Blood-brain barrier</subject><subject>Brain</subject><subject>Care and treatment</subject><subject>Cerebral ischemia</subject><subject>Chinese medicine</subject><subject>Edema</subject><subject>Enzymes</subject><subject>Health aspects</subject><subject>Ischemia</subject><subject>Mannitol</subject><subject>Nitric oxide</subject><subject>Permeability</subject><subject>Stroke</subject><subject>Studies</subject><subject>Veins & arteries</subject><subject>一氧化氮合成酶</subject><subject>动物模型</subject><subject>放血</subject><subject>甘露醇注射液</subject><subject>穿刺治疗</subject><subject>类似</subject><subject>脑缺血</subject><subject>静脉注射</subject><issn>1673-5374</issn><issn>1876-7958</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkstu1TAQhiMEoqXwCsgIFmwSHF-TDVKpyk2V2IBYWo4v5_gosU9tp4g-PQNtjyhCXnjk-fx7_hk3zased3QU45tdF0qJXS8kbTmVrCO4px0WHcbiQXPcD1K0cuTDQ4jvmKPmSSk7jPkwEvq4OSKcYCFGcdxcv5tTsu3sag1xg_ZrNHXNriBdUf3h5iuHPkOi_e7mGe1TiLWg5FHdOrTV0SKjI6rZAW1cdlPWMwrFbN0SNAoRaVTCEmad0aJjdBnV9CcKNc1Pm0dez8U9u91Pmm_vz7-efWwvvnz4dHZ60Ro6yNpOnvLRMmM0t1h65wmnE7ejmEbw54WmdpB-lL2xRlDNCLOO9sQL5sVAIH3SvL3R3a_T4qxxsUKZap_DovNPlXRQ9zMxbNUmXSnWM4F5DwKvbwVyulxdqWoBj9AQHV1ai-q5AFJgiQF9-Q-6S2uOYE8ROhA5UArlH6iNnp0K0Sd41_wWVad0oFxiJhhQ3X8oWBa6a1J0PsD5vQvP_zZ6cHg3bQBe3ABmm-LmEuZ6YBgbB8ngd_wCr6q7Pg</recordid><startdate>20130225</startdate><enddate>20130225</enddate><creator>Lu, Xuan</creator><creator>Chen, Zelin</creator><creator>Guo, Yi</creator><creator>Gao, Liang</creator><creator>Jiang, Liyuan</creator><creator>Li, Zhongzheng</creator><creator>Fang, Jianqiao</creator><general>Medknow Publications and Media Pvt. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neural regeneration research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Xuan</au><au>Chen, Zelin</au><au>Guo, Yi</au><au>Gao, Liang</au><au>Jiang, Liyuan</au><au>Li, Zhongzheng</au><au>Fang, Jianqiao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood-letting punctures at twelve Jing-Well points of the hand can treat cerebral ischemia in a similar manner to mannitol</atitle><jtitle>Neural regeneration research</jtitle><addtitle>Neural Regeneration Research</addtitle><date>2013-02-25</date><risdate>2013</risdate><volume>8</volume><issue>6</issue><spage>532</spage><epage>539</epage><pages>532-539</pages><issn>1673-5374</issn><eissn>1876-7958</eissn><abstract>A rat model of middle cerebral artery permanent occlusion was established using the modified Longa method. Successfully established model animals were treated by blood-letting puncture at twelve Jing-Well points of the hand, and/or by injecting mannitol into the caudal vein twice daily. Brain tissue was collected at 24, 48 and 72 hours after modeling, and blood was collected through the retinal vein before Evans blue was injected, approximately 1 hour prior to harvesting of brain tissue. Results showed that Evans blue leakage into brain tissue and serum nitric oxide synthase activity were significantly increased in model rats. Treatment with blood-letting punctures at twelve Jing-Well points of the hand and/or injection of mannitol into the caudal vein reduced the amount of Evans blue leakage into the brain tissue and serum nitric oxide synthase activity to varying degrees. There was no significant difference between single treatment and combined treatment. Experimental findings indicate that blood-letting punctures at twelve Jing-Well points of the hand can decrease blood-brain barrier permeability and serum nitric oxide synthase activity in rats following middle cerebral artery occlusion, and its effect is similar to that of mannitol injection alone and Jing-Well points plus mannitol injection.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>25206696</pmid><doi>10.3969/j.issn.1673-5374.2013.06.006</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Neural regeneration research, 2013-02, Vol.8 (6), p.532-539 |
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| source | Medknow Open Access Medical Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; Journals@Ovid Complete; PubMed Central Open Access |
| subjects | Acupuncture Acupuncture and Moxibustion and Neural Regeneration Animal experimentation Biosynthesis Blood-brain barrier Brain Care and treatment Cerebral ischemia Chinese medicine Edema Enzymes Health aspects Ischemia Mannitol Nitric oxide Permeability Stroke Studies Veins & arteries 一氧化氮合成酶 动物模型 放血 甘露醇注射液 穿刺治疗 类似 脑缺血 静脉注射 |
| title | Blood-letting punctures at twelve Jing-Well points of the hand can treat cerebral ischemia in a similar manner to mannitol |
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