Basic fibroblast growth factor attenuates the degeneration of injured spinal cord motor endplates
The distal end of the spinal cord and neuromuscular junction may develop secondary degeneration and damage following spinal cord injury because of the loss of neural connections. In this study, a rat model of spinal cord injury, established using a modified Allen's method, was injected with bas...
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| Veröffentlicht in: | Neural regeneration research 2013-08, Vol.8 (24), p.2213-2224 |
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| creator | Wang, Jianlong Sun, Jianfeng Tang, Yongxiang Guo, Gangwen Zhou, Xiaozhe Chen, Yanliang Shen, Minren |
| description | The distal end of the spinal cord and neuromuscular junction may develop secondary degeneration and damage following spinal cord injury because of the loss of neural connections. In this study, a rat model of spinal cord injury, established using a modified Allen's method, was injected with basic fibroblast growth factor solution via subarachnoid catheter. After injection, rats with spinal cord injury displayed higher scores on the Basso, Beattie and Bresnahan locomotor scale. Motor function was also well recovered and hematoxylin-eosin staining showed that spinal glial scar hyperplasia was not apparent. Additionally, anterior tibial muscle fibers slowly, but progressively, atrophied. nohistochemical staining showed that the absorbance values of calcitonin gene related peptide and acetylcholinesterase in anterior tibial muscle and spinal cord were similar, and injection of basic broblast growth factor increased this absorbance. Results showed that after spinal cord injury, the distal motor neurons and motor endplate degenerated. Changes in calcitonin gene related peptide and acetylcholinesterase in the spinal cord anterior horn motor neurons and motor endplate then occurred that were consistent with this regeneration. Our findings indicate that basic fibroblast growth factor can protect the endplate through attenuating the decreased expression of calcitonin gene related peptide and acetylcholinesterase in anterior horn motor neurons of the injured spinal cord. |
| doi_str_mv | 10.3969/j.issn.1673-5374.2013.24.001 |
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In this study, a rat model of spinal cord injury, established using a modified Allen's method, was injected with basic fibroblast growth factor solution via subarachnoid catheter. After injection, rats with spinal cord injury displayed higher scores on the Basso, Beattie and Bresnahan locomotor scale. Motor function was also well recovered and hematoxylin-eosin staining showed that spinal glial scar hyperplasia was not apparent. Additionally, anterior tibial muscle fibers slowly, but progressively, atrophied. nohistochemical staining showed that the absorbance values of calcitonin gene related peptide and acetylcholinesterase in anterior tibial muscle and spinal cord were similar, and injection of basic broblast growth factor increased this absorbance. Results showed that after spinal cord injury, the distal motor neurons and motor endplate degenerated. Changes in calcitonin gene related peptide and acetylcholinesterase in the spinal cord anterior horn motor neurons and motor endplate then occurred that were consistent with this regeneration. Our findings indicate that basic fibroblast growth factor can protect the endplate through attenuating the decreased expression of calcitonin gene related peptide and acetylcholinesterase in anterior horn motor neurons of the injured spinal cord.</description><identifier>ISSN: 1673-5374</identifier><identifier>EISSN: 1876-7958</identifier><identifier>DOI: 10.3969/j.issn.1673-5374.2013.24.001</identifier><identifier>PMID: 25206531</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>Care and treatment ; Catheters ; Cell growth ; Development and progression ; Fibroblast growth factors ; Fibroblasts ; Growth factors ; Health aspects ; Hyperplasia ; Morphology ; Musculoskeletal system ; Neurons ; Peptides ; Physiological aspects ; Physiology ; Research and Report : Spinal Cord Injury and Neural Regeneration ; Spinal cord injuries</subject><ispartof>Neural regeneration research, 2013-08, Vol.8 (24), p.2213-2224</ispartof><rights>COPYRIGHT 2013 Medknow Publications and Media Pvt. Ltd.</rights><rights>2013. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>Copyright: © Neural Regeneration Research 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-abdc2ce5db40fe7bbeffbd29d05bce429325dfd29c1ceced6d4c21d5c821b3ba3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/zgsjzsyj-e/zgsjzsyj-e.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146030/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146030/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25206531$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Jianlong</creatorcontrib><creatorcontrib>Sun, Jianfeng</creatorcontrib><creatorcontrib>Tang, Yongxiang</creatorcontrib><creatorcontrib>Guo, Gangwen</creatorcontrib><creatorcontrib>Zhou, Xiaozhe</creatorcontrib><creatorcontrib>Chen, Yanliang</creatorcontrib><creatorcontrib>Shen, Minren</creatorcontrib><title>Basic fibroblast growth factor attenuates the degeneration of injured spinal cord motor endplates</title><title>Neural regeneration research</title><addtitle>Neural Regen Res</addtitle><description>The distal end of the spinal cord and neuromuscular junction may develop secondary degeneration and damage following spinal cord injury because of the loss of neural connections. In this study, a rat model of spinal cord injury, established using a modified Allen's method, was injected with basic fibroblast growth factor solution via subarachnoid catheter. After injection, rats with spinal cord injury displayed higher scores on the Basso, Beattie and Bresnahan locomotor scale. Motor function was also well recovered and hematoxylin-eosin staining showed that spinal glial scar hyperplasia was not apparent. Additionally, anterior tibial muscle fibers slowly, but progressively, atrophied. nohistochemical staining showed that the absorbance values of calcitonin gene related peptide and acetylcholinesterase in anterior tibial muscle and spinal cord were similar, and injection of basic broblast growth factor increased this absorbance. Results showed that after spinal cord injury, the distal motor neurons and motor endplate degenerated. Changes in calcitonin gene related peptide and acetylcholinesterase in the spinal cord anterior horn motor neurons and motor endplate then occurred that were consistent with this regeneration. Our findings indicate that basic fibroblast growth factor can protect the endplate through attenuating the decreased expression of calcitonin gene related peptide and acetylcholinesterase in anterior horn motor neurons of the injured spinal cord.</description><subject>Care and treatment</subject><subject>Catheters</subject><subject>Cell growth</subject><subject>Development and progression</subject><subject>Fibroblast growth factors</subject><subject>Fibroblasts</subject><subject>Growth factors</subject><subject>Health aspects</subject><subject>Hyperplasia</subject><subject>Morphology</subject><subject>Musculoskeletal system</subject><subject>Neurons</subject><subject>Peptides</subject><subject>Physiological aspects</subject><subject>Physiology</subject><subject>Research and Report : Spinal Cord Injury and Neural Regeneration</subject><subject>Spinal cord injuries</subject><issn>1673-5374</issn><issn>1876-7958</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkkmLFTEUhQtR7EH_ggR0IUiVGSo1bIS2sVVocKPrkOGmXop6yTNJ2XT_elP0oC2SRcLNOd-9OaSq3hDcsLEb38-NS8k3pOtZzVnfNhQT1tC2wZg8qY7J0Hd1P_LhaTnfa46qk5RmjPkwUva8OqKc4o4zclzJjzI5jaxTMahFpoymGK7yDlmpc4hI5gx-lRkSyjtABibwEGV2waNgkfPzGsGgdHBeLkiHaNA-bEbw5rBsvhfVMyuXBC_v9tPqx8Wn7-df6stvn7-en13WuuVdrqUymmrgRrXYQq8UWKsMHQ3mSkNLR0a5saWgiQYNpjOtpsRwPVCimJLstPpwyz2sag9Gg89RLuIQ3V7GaxGkE49vvNuJKfwSLWk7zHABvLsFXElvpZ_EHNZYXpXEzZTmm3Q9C9iypm1Juqjf3rWL4ecKKYu9SxqWRXoIaxKEd4XLu2EDv_5H-kCmbKD9gMeR_FFNcgHhvA1lSr1BxRkbGO_LjF1RNf9RlWVg73TwYF2pPzK8-juWhzzuvwD7DYLTuNc</recordid><startdate>20130825</startdate><enddate>20130825</enddate><creator>Wang, Jianlong</creator><creator>Sun, Jianfeng</creator><creator>Tang, Yongxiang</creator><creator>Guo, Gangwen</creator><creator>Zhou, Xiaozhe</creator><creator>Chen, Yanliang</creator><creator>Shen, Minren</creator><general>Medknow Publications and Media Pvt. Ltd</general><general>Medknow Publications & Media Pvt. Ltd</general><general>Department of 0rthopedics, Third Xiangya Hospital of Central South University, Changsha 410013, Hunan Province, China%Department of 0rthopedics, Yichang Central People’s Hospital, Yichang 443003, Hubei Province, China%Department of Nuclear Medicine, Xiangya Hospital of Central South University, Changsha 410013, Hunan Province, China</general><general>Medknow Publications & Media Pvt Ltd</general><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M2M</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20130825</creationdate><title>Basic fibroblast growth factor attenuates the degeneration of injured spinal cord motor endplates</title><author>Wang, Jianlong ; Sun, Jianfeng ; Tang, Yongxiang ; Guo, Gangwen ; Zhou, Xiaozhe ; Chen, Yanliang ; Shen, Minren</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-abdc2ce5db40fe7bbeffbd29d05bce429325dfd29c1ceced6d4c21d5c821b3ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Care and treatment</topic><topic>Catheters</topic><topic>Cell growth</topic><topic>Development and progression</topic><topic>Fibroblast growth factors</topic><topic>Fibroblasts</topic><topic>Growth factors</topic><topic>Health aspects</topic><topic>Hyperplasia</topic><topic>Morphology</topic><topic>Musculoskeletal system</topic><topic>Neurons</topic><topic>Peptides</topic><topic>Physiological aspects</topic><topic>Physiology</topic><topic>Research and Report : Spinal Cord Injury and Neural Regeneration</topic><topic>Spinal cord injuries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Jianlong</creatorcontrib><creatorcontrib>Sun, Jianfeng</creatorcontrib><creatorcontrib>Tang, Yongxiang</creatorcontrib><creatorcontrib>Guo, Gangwen</creatorcontrib><creatorcontrib>Zhou, Xiaozhe</creatorcontrib><creatorcontrib>Chen, Yanliang</creatorcontrib><creatorcontrib>Shen, Minren</creatorcontrib><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Psychology</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neural regeneration research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Jianlong</au><au>Sun, Jianfeng</au><au>Tang, Yongxiang</au><au>Guo, Gangwen</au><au>Zhou, Xiaozhe</au><au>Chen, Yanliang</au><au>Shen, Minren</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Basic fibroblast growth factor attenuates the degeneration of injured spinal cord motor endplates</atitle><jtitle>Neural regeneration research</jtitle><addtitle>Neural Regen Res</addtitle><date>2013-08-25</date><risdate>2013</risdate><volume>8</volume><issue>24</issue><spage>2213</spage><epage>2224</epage><pages>2213-2224</pages><issn>1673-5374</issn><eissn>1876-7958</eissn><abstract>The distal end of the spinal cord and neuromuscular junction may develop secondary degeneration and damage following spinal cord injury because of the loss of neural connections. In this study, a rat model of spinal cord injury, established using a modified Allen's method, was injected with basic fibroblast growth factor solution via subarachnoid catheter. After injection, rats with spinal cord injury displayed higher scores on the Basso, Beattie and Bresnahan locomotor scale. Motor function was also well recovered and hematoxylin-eosin staining showed that spinal glial scar hyperplasia was not apparent. Additionally, anterior tibial muscle fibers slowly, but progressively, atrophied. nohistochemical staining showed that the absorbance values of calcitonin gene related peptide and acetylcholinesterase in anterior tibial muscle and spinal cord were similar, and injection of basic broblast growth factor increased this absorbance. Results showed that after spinal cord injury, the distal motor neurons and motor endplate degenerated. Changes in calcitonin gene related peptide and acetylcholinesterase in the spinal cord anterior horn motor neurons and motor endplate then occurred that were consistent with this regeneration. Our findings indicate that basic fibroblast growth factor can protect the endplate through attenuating the decreased expression of calcitonin gene related peptide and acetylcholinesterase in anterior horn motor neurons of the injured spinal cord.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>25206531</pmid><doi>10.3969/j.issn.1673-5374.2013.24.001</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Care and treatment Catheters Cell growth Development and progression Fibroblast growth factors Fibroblasts Growth factors Health aspects Hyperplasia Morphology Musculoskeletal system Neurons Peptides Physiological aspects Physiology Research and Report : Spinal Cord Injury and Neural Regeneration Spinal cord injuries |
| title | Basic fibroblast growth factor attenuates the degeneration of injured spinal cord motor endplates |
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