Electric stimulation and decimeter wave therapy improve the recovery of injured sciatic nerves
Drug treatment, electric stimulation and decimeter wave therapy have been shown to promote the repair and regeneration of the peripheral nerves at the injured site. This study prepared a Mackinnon’s model of rat sciatic nerve compression. Electric stimulation was given immediately after neurolysis,...
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| Veröffentlicht in: | Neural regeneration research 2013-07, Vol.8 (21), p.1974-1984 |
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| container_end_page | 1984 |
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| container_issue | 21 |
| container_start_page | 1974 |
| container_title | Neural regeneration research |
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| creator | Zhao, Feng He, Wei Zhang, Yingze Tian, Dehu Zhao, Hongfang Yu, Kunlun Bai, Jiangbo |
| description | Drug treatment, electric stimulation and decimeter wave therapy have been shown to promote the repair and regeneration of the peripheral nerves at the injured site. This study prepared a Mackinnon’s model of rat sciatic nerve compression. Electric stimulation was given immediately after neurolysis, and decimeter wave radiation was performed at 1 and 12 weeks post-operation. Histological observation revealed that intraoperative electric stimulation and decimeter wave therapy could improve the local blood circulation of repaired sites, alleviate hypoxia of compressed nerves, and lessen adhesion of compressed nerves, thereby decreasing the formation of new entrapments and enhancing compressed nerve regeneration through an improved microenvironment for regeneration. Immunohistochemical staining results revealed that intraoperative electric stimulation and decimeter wave could promote the expression of S-100 protein. Motor nerve conduction velocity and amplitude, the number and diameter of myelinated nerve fibers, and sciatic functional index were significantly increased in the treated rats. These results verified that intraoperative electric stimulation and decimeter wave therapy contributed to the regeneration and the recovery of the functions in the compressed nerves. |
| doi_str_mv | 10.3969/j.issn.1673-5374.2013.21.006 |
| format | Article |
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This study prepared a Mackinnon’s model of rat sciatic nerve compression. Electric stimulation was given immediately after neurolysis, and decimeter wave radiation was performed at 1 and 12 weeks post-operation. Histological observation revealed that intraoperative electric stimulation and decimeter wave therapy could improve the local blood circulation of repaired sites, alleviate hypoxia of compressed nerves, and lessen adhesion of compressed nerves, thereby decreasing the formation of new entrapments and enhancing compressed nerve regeneration through an improved microenvironment for regeneration. Immunohistochemical staining results revealed that intraoperative electric stimulation and decimeter wave could promote the expression of S-100 protein. Motor nerve conduction velocity and amplitude, the number and diameter of myelinated nerve fibers, and sciatic functional index were significantly increased in the treated rats. These results verified that intraoperative electric stimulation and decimeter wave therapy contributed to the regeneration and the recovery of the functions in the compressed nerves.</description><identifier>ISSN: 1673-5374</identifier><identifier>EISSN: 1876-7958</identifier><identifier>DOI: 10.3969/j.issn.1673-5374.2013.21.006</identifier><identifier>PMID: 25206506</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>Adhesion ; Animal behavior ; Diabetes ; Edema ; Electric stimulation ; Injuries ; Methods ; Microscopy ; Patient outcomes ; Physical therapy ; Research and Report : Peripheral Nerve Injury and Neural Regeneration ; S-100蛋白 ; Sciatic nerve ; Tendons ; 免疫组化染色 ; 分米波 ; 坐骨神经 ; 电刺激 ; 神经传导速度 ; 神经再生 ; 药物治疗</subject><ispartof>Neural regeneration research, 2013-07, Vol.8 (21), p.1974-1984</ispartof><rights>COPYRIGHT 2013 Medknow Publications and Media Pvt. Ltd.</rights><rights>2013. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>Copyright: © Neural Regeneration Research 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-7f5f2b32dc9667ec3f887ce8bae2dc8a463f2148135a4429ab2662ac91dbd7e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/88507X/88507X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145900/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145900/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25206506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Feng</creatorcontrib><creatorcontrib>He, Wei</creatorcontrib><creatorcontrib>Zhang, Yingze</creatorcontrib><creatorcontrib>Tian, Dehu</creatorcontrib><creatorcontrib>Zhao, Hongfang</creatorcontrib><creatorcontrib>Yu, Kunlun</creatorcontrib><creatorcontrib>Bai, Jiangbo</creatorcontrib><title>Electric stimulation and decimeter wave therapy improve the recovery of injured sciatic nerves</title><title>Neural regeneration research</title><addtitle>Neural Regeneration Research</addtitle><description>Drug treatment, electric stimulation and decimeter wave therapy have been shown to promote the repair and regeneration of the peripheral nerves at the injured site. This study prepared a Mackinnon’s model of rat sciatic nerve compression. Electric stimulation was given immediately after neurolysis, and decimeter wave radiation was performed at 1 and 12 weeks post-operation. Histological observation revealed that intraoperative electric stimulation and decimeter wave therapy could improve the local blood circulation of repaired sites, alleviate hypoxia of compressed nerves, and lessen adhesion of compressed nerves, thereby decreasing the formation of new entrapments and enhancing compressed nerve regeneration through an improved microenvironment for regeneration. Immunohistochemical staining results revealed that intraoperative electric stimulation and decimeter wave could promote the expression of S-100 protein. Motor nerve conduction velocity and amplitude, the number and diameter of myelinated nerve fibers, and sciatic functional index were significantly increased in the treated rats. These results verified that intraoperative electric stimulation and decimeter wave therapy contributed to the regeneration and the recovery of the functions in the compressed nerves.</description><subject>Adhesion</subject><subject>Animal behavior</subject><subject>Diabetes</subject><subject>Edema</subject><subject>Electric stimulation</subject><subject>Injuries</subject><subject>Methods</subject><subject>Microscopy</subject><subject>Patient outcomes</subject><subject>Physical therapy</subject><subject>Research and Report : Peripheral Nerve Injury and Neural Regeneration</subject><subject>S-100蛋白</subject><subject>Sciatic nerve</subject><subject>Tendons</subject><subject>免疫组化染色</subject><subject>分米波</subject><subject>坐骨神经</subject><subject>电刺激</subject><subject>神经传导速度</subject><subject>神经再生</subject><subject>药物治疗</subject><issn>1673-5374</issn><issn>1876-7958</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkU1v1DAQhiMEoqXwF5ARHJDQBn_buSBVVfmQKnHpGctxJruOEntrJ1ttfz2utlsoQj54PH7m9czrqvpAcM0a2Xweap9zqIlUbCWY4jXFhNWU1BjLZ9Up0UquVCP08xIfmZPqVc4DxkI3lL2sTqigWAosT6tflyO4OXmH8uynZbSzjwHZ0KEOnJ9ghoRu7Q7QvIFkt3vkp22KhzNK4EqY9ij2yIdhSdCh7HzRcChA2kF-Xb3o7ZjhzcN-Vl1_vby--L66-vntx8X51cpxTeeV6kVPW0Y710ipwLFea-VAtxZKTlsuWU8J14QJyzltbEulpNY1pGs7Beys-nKQ3S7tBJ2DMCc7mm3yk017E603T2-C35h13BlOuGgwLgKfDgK3NvQ2rM0QlxRKx-ZunYe7vB8M3PtMCcaq0B8fnkvxZoE8m8lnB-NoA8QlGyIk4VIowQv6_h_0UZkyTZXWkjZ_qLUdwfjQx9Kluxc150wzoTDDtFD1f6iyOpi8iwF6X_JPCt7-bcujH8fvL8C7A-A2MaxvfBn8yHBdxm2wYL8BS7XAuw</recordid><startdate>20130725</startdate><enddate>20130725</enddate><creator>Zhao, Feng</creator><creator>He, Wei</creator><creator>Zhang, Yingze</creator><creator>Tian, Dehu</creator><creator>Zhao, Hongfang</creator><creator>Yu, Kunlun</creator><creator>Bai, Jiangbo</creator><general>Medknow Publications and Media Pvt. Ltd</general><general>Medknow Publications & Media Pvt. Ltd</general><general>Department of 0rthopedics, the First Hospital of Hebei Medical University, Shijiazhuang 050031, Hebei Province, China%Department of Hand Surgery, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei Province, China</general><general>Medknow Publications & Media Pvt Ltd</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M2M</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20130725</creationdate><title>Electric stimulation and decimeter wave therapy improve the recovery of injured sciatic nerves</title><author>Zhao, Feng ; He, Wei ; Zhang, Yingze ; Tian, Dehu ; Zhao, Hongfang ; Yu, Kunlun ; Bai, Jiangbo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-7f5f2b32dc9667ec3f887ce8bae2dc8a463f2148135a4429ab2662ac91dbd7e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adhesion</topic><topic>Animal behavior</topic><topic>Diabetes</topic><topic>Edema</topic><topic>Electric stimulation</topic><topic>Injuries</topic><topic>Methods</topic><topic>Microscopy</topic><topic>Patient outcomes</topic><topic>Physical therapy</topic><topic>Research and Report : Peripheral Nerve Injury and Neural Regeneration</topic><topic>S-100蛋白</topic><topic>Sciatic nerve</topic><topic>Tendons</topic><topic>免疫组化染色</topic><topic>分米波</topic><topic>坐骨神经</topic><topic>电刺激</topic><topic>神经传导速度</topic><topic>神经再生</topic><topic>药物治疗</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Feng</creatorcontrib><creatorcontrib>He, Wei</creatorcontrib><creatorcontrib>Zhang, Yingze</creatorcontrib><creatorcontrib>Tian, Dehu</creatorcontrib><creatorcontrib>Zhao, Hongfang</creatorcontrib><creatorcontrib>Yu, Kunlun</creatorcontrib><creatorcontrib>Bai, Jiangbo</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Psychology</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neural regeneration research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Feng</au><au>He, Wei</au><au>Zhang, Yingze</au><au>Tian, Dehu</au><au>Zhao, Hongfang</au><au>Yu, Kunlun</au><au>Bai, Jiangbo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electric stimulation and decimeter wave therapy improve the recovery of injured sciatic nerves</atitle><jtitle>Neural regeneration research</jtitle><addtitle>Neural Regeneration Research</addtitle><date>2013-07-25</date><risdate>2013</risdate><volume>8</volume><issue>21</issue><spage>1974</spage><epage>1984</epage><pages>1974-1984</pages><issn>1673-5374</issn><eissn>1876-7958</eissn><abstract>Drug treatment, electric stimulation and decimeter wave therapy have been shown to promote the repair and regeneration of the peripheral nerves at the injured site. This study prepared a Mackinnon’s model of rat sciatic nerve compression. Electric stimulation was given immediately after neurolysis, and decimeter wave radiation was performed at 1 and 12 weeks post-operation. Histological observation revealed that intraoperative electric stimulation and decimeter wave therapy could improve the local blood circulation of repaired sites, alleviate hypoxia of compressed nerves, and lessen adhesion of compressed nerves, thereby decreasing the formation of new entrapments and enhancing compressed nerve regeneration through an improved microenvironment for regeneration. Immunohistochemical staining results revealed that intraoperative electric stimulation and decimeter wave could promote the expression of S-100 protein. Motor nerve conduction velocity and amplitude, the number and diameter of myelinated nerve fibers, and sciatic functional index were significantly increased in the treated rats. These results verified that intraoperative electric stimulation and decimeter wave therapy contributed to the regeneration and the recovery of the functions in the compressed nerves.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>25206506</pmid><doi>10.3969/j.issn.1673-5374.2013.21.006</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | Journals@Ovid Ovid Autoload; Medknow Open Access Medical Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Adhesion Animal behavior Diabetes Edema Electric stimulation Injuries Methods Microscopy Patient outcomes Physical therapy Research and Report : Peripheral Nerve Injury and Neural Regeneration S-100蛋白 Sciatic nerve Tendons 免疫组化染色 分米波 坐骨神经 电刺激 神经传导速度 神经再生 药物治疗 |
| title | Electric stimulation and decimeter wave therapy improve the recovery of injured sciatic nerves |
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