Multimodality magnetic resonance imaging in hepatic encephalopathy: An update

Hepatic encephalopathy(HE) is a neuropsychiatric complication of cirrhosis or acute liver failure. Currently, HE is regarded as a continuous cognitive impairment ranging from the mildest stage, minimal HE to overt HE. Hyperammonaemia and neuroinflammation are two main underlying factors which contri...

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Veröffentlicht in:World journal of gastroenterology : WJG 2014-08, Vol.20 (32), p.11262-11272
Hauptverfasser: Zhang, Xiao-Dong, Zhang, Long-Jiang, Wu, Sheng-Yong, Lu, Guang-Ming
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container_end_page 11272
container_issue 32
container_start_page 11262
container_title World journal of gastroenterology : WJG
container_volume 20
creator Zhang, Xiao-Dong
Zhang, Long-Jiang
Wu, Sheng-Yong
Lu, Guang-Ming
description Hepatic encephalopathy(HE) is a neuropsychiatric complication of cirrhosis or acute liver failure. Currently, HE is regarded as a continuous cognitive impairment ranging from the mildest stage, minimal HE to overt HE. Hyperammonaemia and neuroinflammation are two main underlying factors which contribute to the neurological alterations in HE. Both structural and functional impairments are found in the white mater and grey mater involved in HE. Although the investigations into HE pathophysiological mechanism are enormous, the exact pathophysiological causes underlying HE remain controversial. Multimodality magnetic resonance imaging(MRI) plays an important role in helping to understand the pathological process of HE. This paper reviews the up-to-date multimodality MRI methods and predominant findings in HE patients with a highlight ofthe increasingly important role of blood oxygen level dependent functional MRI.
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subjects Biomarkers - blood
Brain - metabolism
Brain - pathology
Diffusion Magnetic Resonance Imaging
encephalopathy
Hepatic
Hepatic Encephalopathy - blood
Hepatic Encephalopathy - diagnosis
Hepatic Encephalopathy - pathology
Humans
imaging
Magnetic
Magnetic Resonance Imaging - methods
Magnetic Resonance Spectroscopy
Multimodal Imaging - methods
Oxygen - blood
Perfusion Imaging
Predictive Value of Tests
resonance
Review
title Multimodality magnetic resonance imaging in hepatic encephalopathy: An update
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