Vitamin E dietary supplementation improves neurological symptoms and decreases c-Abl/p73 activation in Niemann-Pick C mice

Niemann-Pick C (NPC) disease is a fatal neurodegenerative disorder characterized by the accumulation of free cholesterol in lysosomes. We have previously reported that oxidative stress is the main upstream stimulus activating the proapoptotic c-Abl/p73 pathway in NPC neurons. We have also observed a...

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Veröffentlicht in:	Nutrients 2014-07, Vol.6 (8), p.3000-3017
Hauptverfasser:	Marín, Tamara, Contreras, Pablo, Castro, Juan Francisco, Chamorro, David, Balboa, Elisa, Bosch-Morató, Mònica, Muñoz, Francisco J, Alvarez, Alejandra R, Zanlungo, Silvana
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Tocopherol Animals Antioxidants Apoptosis Ataxia bioavailability c-Abl Caspase 3 - genetics Caspase 3 - metabolism Cell Line Cell Survival - drug effects cerebellum Cholesterol Diet Dietary Supplements Disease Models, Animal DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Lysosomes Lysosomes - drug effects Lysosomes - metabolism Male Mice Mice, Inbred BALB C Mice, Knockout Mutation Neurodegeneration neurodegenerative diseases Neurodegenerative Diseases - drug therapy Neurons Niemann-Pick C Niemann-Pick Disease, Type C - drug therapy Niemann-Pick Disease, Type C - genetics Nuclear Proteins - genetics Nuclear Proteins - metabolism Oxidative stress Oxidative Stress - drug effects patients Proteïna tirosina-quinasa Proteïnes de la sang Proto-Oncogene Proteins c-abl - genetics Proto-Oncogene Proteins c-abl - metabolism Receptors Signal Transduction Tumor Protein p73 Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tyrosine - analogs & derivatives Tyrosine - metabolism Vitamin E Vitamin E - administration & dosage weight loss
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