A selective USP1–UAF1 inhibitor links deubiquitination to DNA damage responses

Deubiquitinases (DUBs) are peptidases that remove ubiquitin from post-translationally modified proteins. The identification of a selective small-molecule inhibitor of the USP1–UAF1 deubiquitination complex reveals a role for deubiquitination in regulating the DNA damage response. Protein ubiquitinat...

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Veröffentlicht in:	Nature chemical biology 2014-04, Vol.10 (4), p.298-304
Hauptverfasser:	Liang, Qin, Dexheimer, Thomas S, Zhang, Ping, Rosenthal, Andrew S, Villamil, Mark A, You, Changjun, Zhang, Qiuting, Chen, Junjun, Ott, Christine A, Sun, Hongmao, Luci, Diane K, Yuan, Bifeng, Simeonov, Anton, Jadhav, Ajit, Xiao, Hui, Wang, Yinsheng, Maloney, David J, Zhuang, Zhihao
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/89 14/19 49/47 49/98 631/92/458 631/92/468 631/92/613 692/699/67/1059 82/80 Algorithms Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Arabidopsis Proteins - antagonists & inhibitors Biochemical Engineering Biochemistry Bioorganic Chemistry Butyrates - pharmacology Cancer Cell Biology Cell Line, Tumor Cell Survival - drug effects Chemistry Chemistry/Food Science Cisplatin - pharmacology Colony-Forming Units Assay Cytotoxicity Deoxyribonucleic acid DNA DNA damage DNA Damage - genetics DNA Damage - physiology DNA repair DNA, Neoplasm - antagonists & inhibitors DNA, Neoplasm - biosynthesis Drug Resistance, Neoplasm Electrophoresis, Polyacrylamide Gel Fanconi Anemia - genetics Fanconi Anemia Complementation Group D2 Protein - antagonists & inhibitors High-Throughput Screening Assays Humans Indicators and Reagents Lung cancer Nuclear Proteins - antagonists & inhibitors Pharmaceutical sciences Phenylurea Compounds - pharmacology Pimozide - pharmacology Platinum Probes Proliferating Cell Nuclear Antigen - drug effects Proliferating Cell Nuclear Antigen - metabolism Proteins Recombinant Proteins - chemistry Recombination, Genetic - drug effects RNA, Small Interfering - genetics Signal transduction Sister Chromatid Exchange - drug effects Ubiquitin-Specific Proteases - antagonists & inhibitors Ubiquitination - drug effects
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