The pathogenesis of chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is characterized by the clonal expansion of CD5(+)CD23(+) B cells in blood, marrow, and second lymphoid tissues. Gene-expression profiling and phenotypic studies suggest that CLL is probably derived from CD5(+) B cells similar to those found in the blood of healthy...

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Veröffentlicht in:	Annual review of pathology 2014-01, Vol.9 (1), p.103-118
Hauptverfasser:	Zhang, Suping, Kipps, Thomas J
Format:	Artikel
Sprache:	eng
Schlagworte:	B-Lymphocytes - immunology Cell Proliferation Cellular Microenvironment Disease Progression Gene Expression Humans Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - immunology Leukemia, Lymphocytic, Chronic, B-Cell - pathology Leukemia, Lymphocytic, Chronic, B-Cell - therapy Signal Transduction
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