Bromine is an essential trace element for assembly of collagen IV scaffolds in tissue development and architecture

Bromine is ubiquitously present in animals as ionic bromide (Br(-)) yet has no known essential function. Herein, we demonstrate that Br(-) is a required cofactor for peroxidasin-catalyzed formation of sulfilimine crosslinks, a posttranslational modification essential for tissue development and archi...

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Veröffentlicht in:	Cell 2014-06, Vol.157 (6), p.1380-1392
Hauptverfasser:	McCall, A Scott, Cummings, Christopher F, Bhave, Gautam, Vanacore, Roberto, Page-McCaw, Andrea, Hudson, Billy G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basement Membrane - metabolism Basement Membrane - ultrastructure bromides bromine Bromine - deficiency Bromine - metabolism Cell Line collagen Collagen - metabolism crosslinking Drosophila Drosophila - growth & development Drosophila - metabolism Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Humans Imines - metabolism Larva - ultrastructure Mice mutants Peroxidase - genetics Peroxidase - metabolism Peroxidasin post-translational modification tissue scaffolds Trace Elements - metabolism viability
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