Expression of Human CD46 Modulates Inflammation Associated With GalTKO Lung Xenograft Injury

Evaluation of lungs from GalTKO.hCD46 pigs, genetically modified to lack the galactose‐α(1,3)‐galactose epitope (GalTKO) and to express human CD46, a complement regulatory protein, has not previously been described. Physiologic, hematologic and biochemical parameters during perfusion with heparinize...

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Veröffentlicht in:	American journal of transplantation 2014-05, Vol.14 (5), p.1084-1095
Hauptverfasser:	Burdorf, L., Stoddard, T., Zhang, T., Rybak, E., Riner, A., Avon, C., Laaris, A., Cheng, X., Sievert, E., Braileanu, G., Newton, A., Phelps, C. J., Ayares, D., Azimzadeh, A. M., Pierson, R. N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Blood Coagulation - immunology CD55 Antigens - genetics Coagulation complement Complement Activation - immunology Epitopes - immunology ex vivo perfusion Galactosyltransferases - physiology GalTKO.hCD46 Graft Survival - physiology Histamine - metabolism Humans Immunoenzyme Techniques Inflammation - immunology Inflammation - metabolism Inflammation - pathology leukocyte adhesion lung Lung Injury - immunology Lung Injury - pathology Lung Injury - surgery Lung Transplantation Neutrophils - metabolism platelet activation Swine Swine, Miniature Transplantation, Heterologous xenotransplantation
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