Aspirin Treatment Improved Mesenchymal Stem Cell Immunomodulatory Properties via the 15d-PGJ2/PPARγ/TGF-β1 Pathway
Bone marrow mesenchymal stem cells (BMMSCs) have been used to treat a variety of autoimmune diseases in clinics. However, the therapeutic effects are largely dependent on the immunomodulatory capacity of culture-expanded BMMSCs. In the present study, we show that aspirin (acetylsalicylic acid, ASA)-...
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| Veröffentlicht in: | Stem cells and development 2014-09, Vol.23 (17), p.293-2103 |
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| creator | Tang, Jianxia Xiong, Jimin Wu, Tingting Tang, Zhangui Ding, Gang Zhang, Chunmei Wang, Songlin Liu, Yi |
| description | Bone marrow mesenchymal stem cells (BMMSCs) have been used to treat a variety of autoimmune diseases in clinics. However, the therapeutic effects are largely dependent on the immunomodulatory capacity of culture-expanded BMMSCs. In the present study, we show that aspirin (acetylsalicylic acid, ASA)-treated BMMSCs have significantly improved immunomodulatory function, as indicated by upregulation of regulatory T cells (Tregs) and downregulation of Th17 cells via the 15d-PGJ
2
/PPARγ/TGF-β1 pathway. Furthermore, the therapeutic effect of ASA-pretreated BMMSCs was confirmed in a dextran sodium sulfate-induced experimental colitis mouse model, in which systemic infusion of ASA-pretreated BMMSCs significantly ameliorated disease activity index and colonic inflammation, along with an increased number of Tregs and decreased number of Th17 cells. Taken together, our results suggest that aspirin treatment is a feasible strategy to promote BMMSC-based immunomodulation. |
| doi_str_mv | 10.1089/scd.2014.0081 |
| format | Article |
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2
/PPARγ/TGF-β1 pathway. Furthermore, the therapeutic effect of ASA-pretreated BMMSCs was confirmed in a dextran sodium sulfate-induced experimental colitis mouse model, in which systemic infusion of ASA-pretreated BMMSCs significantly ameliorated disease activity index and colonic inflammation, along with an increased number of Tregs and decreased number of Th17 cells. Taken together, our results suggest that aspirin treatment is a feasible strategy to promote BMMSC-based immunomodulation.</description><identifier>ISSN: 1547-3287</identifier><identifier>EISSN: 1557-8534</identifier><identifier>DOI: 10.1089/scd.2014.0081</identifier><identifier>PMID: 24730450</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Animals ; Apoptosis ; Aspirin - pharmacology ; Cell Proliferation ; Cells, Cultured ; Coculture Techniques ; Colitis - immunology ; Colitis - therapy ; Dinoprostone - metabolism ; Female ; Immunomodulation - drug effects ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stromal Cells - drug effects ; Mesenchymal Stromal Cells - physiology ; Mice, Inbred C57BL ; Original Research Reports ; PPAR gamma - metabolism ; Prostaglandin D2 - analogs & derivatives ; Prostaglandin D2 - metabolism ; Signal Transduction ; T-Lymphocytes, Regulatory - immunology ; Th17 Cells - immunology ; Transforming Growth Factor beta1 - metabolism</subject><ispartof>Stem cells and development, 2014-09, Vol.23 (17), p.293-2103</ispartof><rights>2014, Mary Ann Liebert, Inc.</rights><rights>Copyright 2014, Mary Ann Liebert, Inc. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24730450$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tang, Jianxia</creatorcontrib><creatorcontrib>Xiong, Jimin</creatorcontrib><creatorcontrib>Wu, Tingting</creatorcontrib><creatorcontrib>Tang, Zhangui</creatorcontrib><creatorcontrib>Ding, Gang</creatorcontrib><creatorcontrib>Zhang, Chunmei</creatorcontrib><creatorcontrib>Wang, Songlin</creatorcontrib><creatorcontrib>Liu, Yi</creatorcontrib><title>Aspirin Treatment Improved Mesenchymal Stem Cell Immunomodulatory Properties via the 15d-PGJ2/PPARγ/TGF-β1 Pathway</title><title>Stem cells and development</title><addtitle>Stem Cells Dev</addtitle><description>Bone marrow mesenchymal stem cells (BMMSCs) have been used to treat a variety of autoimmune diseases in clinics. However, the therapeutic effects are largely dependent on the immunomodulatory capacity of culture-expanded BMMSCs. In the present study, we show that aspirin (acetylsalicylic acid, ASA)-treated BMMSCs have significantly improved immunomodulatory function, as indicated by upregulation of regulatory T cells (Tregs) and downregulation of Th17 cells via the 15d-PGJ
2
/PPARγ/TGF-β1 pathway. Furthermore, the therapeutic effect of ASA-pretreated BMMSCs was confirmed in a dextran sodium sulfate-induced experimental colitis mouse model, in which systemic infusion of ASA-pretreated BMMSCs significantly ameliorated disease activity index and colonic inflammation, along with an increased number of Tregs and decreased number of Th17 cells. Taken together, our results suggest that aspirin treatment is a feasible strategy to promote BMMSC-based immunomodulation.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Aspirin - pharmacology</subject><subject>Cell Proliferation</subject><subject>Cells, Cultured</subject><subject>Coculture Techniques</subject><subject>Colitis - immunology</subject><subject>Colitis - therapy</subject><subject>Dinoprostone - metabolism</subject><subject>Female</subject><subject>Immunomodulation - drug effects</subject><subject>Mesenchymal Stem Cell Transplantation</subject><subject>Mesenchymal Stromal Cells - drug effects</subject><subject>Mesenchymal Stromal Cells - physiology</subject><subject>Mice, Inbred C57BL</subject><subject>Original Research Reports</subject><subject>PPAR gamma - metabolism</subject><subject>Prostaglandin D2 - analogs & derivatives</subject><subject>Prostaglandin D2 - metabolism</subject><subject>Signal Transduction</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>Th17 Cells - immunology</subject><subject>Transforming Growth Factor beta1 - metabolism</subject><issn>1547-3287</issn><issn>1557-8534</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUdtKw0AQXUSxtfroq-wPpN1bstsXoRRbKxWD1udlk2xtJJuEzbaS39L_6De5oVoUBmaYc-YwMweAa4yGGInxqEmzIUGYDRES-AT0cRjyQISUnXY14wElgvfARdO8I0QiItg56BHGKWIh6gM3aerc5iVcWa2c0aWDC1Pbaqcz-KgbXaab1qgCvjht4FQXhYfNtqxMlW0L5SrbwthWtbYu1w3c5Qq6jYY4zIJ4_kBGcTx53n-NVvNZsP_EMFZu86HaS3C2VkWjr37yALzO7lbT-2D5NF9MJ8vAkIjhgHM8jkKcjQlN_LaC-wPCJF3jhIWKpJwlXCfZGntYCY0pVhGjiIgs1URRHwNwe9Ctt4nRvl06qwpZ29wo28pK5fI_UuYb-VbtJMOMCEq9wM1fgePk7_88gR4IXVuVZZHrxP_iSMRIdi5J75LsXJKdS_QbSgiFiQ</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Tang, Jianxia</creator><creator>Xiong, Jimin</creator><creator>Wu, Tingting</creator><creator>Tang, Zhangui</creator><creator>Ding, Gang</creator><creator>Zhang, Chunmei</creator><creator>Wang, Songlin</creator><creator>Liu, Yi</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>5PM</scope></search><sort><creationdate>20140901</creationdate><title>Aspirin Treatment Improved Mesenchymal Stem Cell Immunomodulatory Properties via the 15d-PGJ2/PPARγ/TGF-β1 Pathway</title><author>Tang, Jianxia ; Xiong, Jimin ; Wu, Tingting ; Tang, Zhangui ; Ding, Gang ; Zhang, Chunmei ; Wang, Songlin ; Liu, Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-m2641-7719651d923b045870025bcf1b45a2c74b7ebdf123ba8e131a643028dce2a32a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Aspirin - pharmacology</topic><topic>Cell Proliferation</topic><topic>Cells, Cultured</topic><topic>Coculture Techniques</topic><topic>Colitis - immunology</topic><topic>Colitis - therapy</topic><topic>Dinoprostone - metabolism</topic><topic>Female</topic><topic>Immunomodulation - drug effects</topic><topic>Mesenchymal Stem Cell Transplantation</topic><topic>Mesenchymal Stromal Cells - drug effects</topic><topic>Mesenchymal Stromal Cells - physiology</topic><topic>Mice, Inbred C57BL</topic><topic>Original Research Reports</topic><topic>PPAR gamma - metabolism</topic><topic>Prostaglandin D2 - analogs & derivatives</topic><topic>Prostaglandin D2 - metabolism</topic><topic>Signal Transduction</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>Th17 Cells - immunology</topic><topic>Transforming Growth Factor beta1 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tang, Jianxia</creatorcontrib><creatorcontrib>Xiong, Jimin</creatorcontrib><creatorcontrib>Wu, Tingting</creatorcontrib><creatorcontrib>Tang, Zhangui</creatorcontrib><creatorcontrib>Ding, Gang</creatorcontrib><creatorcontrib>Zhang, Chunmei</creatorcontrib><creatorcontrib>Wang, Songlin</creatorcontrib><creatorcontrib>Liu, Yi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Stem cells and development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tang, Jianxia</au><au>Xiong, Jimin</au><au>Wu, Tingting</au><au>Tang, Zhangui</au><au>Ding, Gang</au><au>Zhang, Chunmei</au><au>Wang, Songlin</au><au>Liu, Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aspirin Treatment Improved Mesenchymal Stem Cell Immunomodulatory Properties via the 15d-PGJ2/PPARγ/TGF-β1 Pathway</atitle><jtitle>Stem cells and development</jtitle><addtitle>Stem Cells Dev</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>23</volume><issue>17</issue><spage>293</spage><epage>2103</epage><pages>293-2103</pages><issn>1547-3287</issn><eissn>1557-8534</eissn><abstract>Bone marrow mesenchymal stem cells (BMMSCs) have been used to treat a variety of autoimmune diseases in clinics. However, the therapeutic effects are largely dependent on the immunomodulatory capacity of culture-expanded BMMSCs. In the present study, we show that aspirin (acetylsalicylic acid, ASA)-treated BMMSCs have significantly improved immunomodulatory function, as indicated by upregulation of regulatory T cells (Tregs) and downregulation of Th17 cells via the 15d-PGJ
2
/PPARγ/TGF-β1 pathway. Furthermore, the therapeutic effect of ASA-pretreated BMMSCs was confirmed in a dextran sodium sulfate-induced experimental colitis mouse model, in which systemic infusion of ASA-pretreated BMMSCs significantly ameliorated disease activity index and colonic inflammation, along with an increased number of Tregs and decreased number of Th17 cells. Taken together, our results suggest that aspirin treatment is a feasible strategy to promote BMMSC-based immunomodulation.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>24730450</pmid><doi>10.1089/scd.2014.0081</doi><tpages>1811</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Apoptosis Aspirin - pharmacology Cell Proliferation Cells, Cultured Coculture Techniques Colitis - immunology Colitis - therapy Dinoprostone - metabolism Female Immunomodulation - drug effects Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - physiology Mice, Inbred C57BL Original Research Reports PPAR gamma - metabolism Prostaglandin D2 - analogs & derivatives Prostaglandin D2 - metabolism Signal Transduction T-Lymphocytes, Regulatory - immunology Th17 Cells - immunology Transforming Growth Factor beta1 - metabolism |
| title | Aspirin Treatment Improved Mesenchymal Stem Cell Immunomodulatory Properties via the 15d-PGJ2/PPARγ/TGF-β1 Pathway |
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