E-cadherin phosphorylation occurs during its biosynthesis to promote its cell surface stability and adhesion

E-cadherin is highly phosphorylated within its β-catenin-binding region, and this phosphorylation increases its affinity for β-catenin in vitro. However, the identification of key serines responsible for most cadherin phosphorylation and the adhesive consequences of modification at such serines have...

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Veröffentlicht in:	Molecular biology of the cell 2014-08, Vol.25 (16), p.2365-2374
Hauptverfasser:	McEwen, Abbye E, Maher, Meghan T, Mo, Rigen, Gottardi, Cara J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin - metabolism Cadherins - biosynthesis Cell Adhesion Cell Line Cell Membrane - metabolism Cercopithecus aethiops COS Cells Endocytosis Humans Phosphorylation Protein Binding Serine - metabolism
Online-Zugang:	Volltext
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