Characterization of Glial Cell Models and In Vitro Manipulation of the Neuregulin1/ErbB System
The neuregulin1/ErbB system plays an important role in Schwann cell behavior both in normal and pathological conditions. Upon investigation of the expression of the neuregulin1/ErbB system in vitro, we explored the possibility to manipulate the system in order to increase the migration of Schwann ce...
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| Veröffentlicht in: | BioMed research international 2014-01, Vol.2014 (2014), p.1-15 |
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| creator | Dell'Albani, Paola Zaccheo, Damiano Perroteau, Isabelle Pellitteri, Rosalia Gambarotta, Giovanna Pascal, Davide Fregnan, Federica Morano, Michela de Winter, Fred Giovannelli, Alessia Gnavi, Sara Hoyng, Stefan Adriaan |
| description | The neuregulin1/ErbB system plays an important role in Schwann cell behavior both in normal and pathological conditions. Upon investigation of the expression of the neuregulin1/ErbB system in vitro, we explored the possibility to manipulate the system in order to increase the migration of Schwann cells, that play a fundamental role in the peripheral nerve regeneration. Comparison of primary cells and stable cell lines shows that both primary olfactory bulb ensheathing cells and a corresponding cell line express ErbB1-ErbB2 and neuregulin1, and that both primary Schwann cells and a corresponding cell line express ErbB2-ErbB3, while only primary Schwann cells express neuregulin1. To interfere with the neuregulin1/ErbB system, the soluble extracellular domain of the neuregulin1 receptor ErbB4 (ecto-ErbB4) was expressed in vitro in the neuregulin1 expressing cell line, and an unexpected increase in cell motility was observed. In vitro experiments suggest that the back signaling mediated by the transmembrane neuregulin1 plays a role in the migratory activity induced by ecto-ErbB4. These results indicate that ecto-ErbB4 could be used in vivo as a tool to manipulate the neuregulin1/ErbB system. |
| doi_str_mv | 10.1155/2014/310215 |
| format | Article |
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Upon investigation of the expression of the neuregulin1/ErbB system in vitro, we explored the possibility to manipulate the system in order to increase the migration of Schwann cells, that play a fundamental role in the peripheral nerve regeneration. Comparison of primary cells and stable cell lines shows that both primary olfactory bulb ensheathing cells and a corresponding cell line express ErbB1-ErbB2 and neuregulin1, and that both primary Schwann cells and a corresponding cell line express ErbB2-ErbB3, while only primary Schwann cells express neuregulin1. To interfere with the neuregulin1/ErbB system, the soluble extracellular domain of the neuregulin1 receptor ErbB4 (ecto-ErbB4) was expressed in vitro in the neuregulin1 expressing cell line, and an unexpected increase in cell motility was observed. In vitro experiments suggest that the back signaling mediated by the transmembrane neuregulin1 plays a role in the migratory activity induced by ecto-ErbB4. These results indicate that ecto-ErbB4 could be used in vivo as a tool to manipulate the neuregulin1/ErbB system.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/310215</identifier><identifier>PMID: 25177687</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Animals ; Biomedical research ; Cell Line ; Cell Movement - physiology ; Kinases ; Ligands ; Nerve Regeneration - physiology ; Neuregulin-1 - metabolism ; Neurosciences ; Phosphorylation ; Rats ; Receptor, ErbB-4 - metabolism ; Rodents ; Schwann Cells - cytology ; Schwann Cells - physiology ; Studies</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-15</ispartof><rights>Copyright © 2014 Davide Pascal et al.</rights><rights>Copyright © 2014 Davide Pascal et al. Davide Pascal et al. 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Upon investigation of the expression of the neuregulin1/ErbB system in vitro, we explored the possibility to manipulate the system in order to increase the migration of Schwann cells, that play a fundamental role in the peripheral nerve regeneration. Comparison of primary cells and stable cell lines shows that both primary olfactory bulb ensheathing cells and a corresponding cell line express ErbB1-ErbB2 and neuregulin1, and that both primary Schwann cells and a corresponding cell line express ErbB2-ErbB3, while only primary Schwann cells express neuregulin1. To interfere with the neuregulin1/ErbB system, the soluble extracellular domain of the neuregulin1 receptor ErbB4 (ecto-ErbB4) was expressed in vitro in the neuregulin1 expressing cell line, and an unexpected increase in cell motility was observed. In vitro experiments suggest that the back signaling mediated by the transmembrane neuregulin1 plays a role in the migratory activity induced by ecto-ErbB4. 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| source | MEDLINE; Wiley Online Library Open Access; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Animals Biomedical research Cell Line Cell Movement - physiology Kinases Ligands Nerve Regeneration - physiology Neuregulin-1 - metabolism Neurosciences Phosphorylation Rats Receptor, ErbB-4 - metabolism Rodents Schwann Cells - cytology Schwann Cells - physiology Studies |
| title | Characterization of Glial Cell Models and In Vitro Manipulation of the Neuregulin1/ErbB System |
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