Functional connectivity during cognitive control in children with autism spectrum disorder: an independent component analysis
Restrictive and repetitive behavior in autism may be related to deficits in cognitive control. Here, we aimed to assess functional connectivity during a cognitive control task and compare brain network activity and connectivity in children with autism spectrum disorders (ASD) and typically developin...
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| Veröffentlicht in: | Journal of Neural Transmission 2014-09, Vol.121 (9), p.1145-1155 |
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| container_title | Journal of Neural Transmission |
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| creator | Ambrosino, S. Bos, D. J. van Raalten, T. R. Kobussen, N. A. van Belle, J. Oranje, B. Durston, S. |
| description | Restrictive and repetitive behavior in autism may be related to deficits in cognitive control. Here, we aimed to assess functional connectivity during a cognitive control task and compare brain network activity and connectivity in children with autism spectrum disorders (ASD) and typically developing children using a multivariate data-driven approach. 19 high-functioning boys with ASD and 19 age-matched typically developing boys were included in this study. Functional magnetic resonance imaging was performed at 3T during the performance of a cognitive control task (go/no-go paradigm). Functional networks were identified using independent component analysis. Network activity and connectivity was compared between groups and correlated with clinical measures of rigid behavior using multivariate analysis of covariance. We found no differences between the groups in task performance or in network activity. Power analysis indicated that, if this were a real difference, it would require nearly 800 subjects to show group differences in network activity using this paradigm. Neither were there correlations between network activity and rigid behavior. Our data do not provide support for the presence of deficits in cognitive control in children with ASD, or the functional networks supporting this ability. |
| doi_str_mv | 10.1007/s00702-014-1237-8 |
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J. ; van Raalten, T. R. ; Kobussen, N. A. ; van Belle, J. ; Oranje, B. ; Durston, S.</creator><creatorcontrib>Ambrosino, S. ; Bos, D. J. ; van Raalten, T. R. ; Kobussen, N. A. ; van Belle, J. ; Oranje, B. ; Durston, S.</creatorcontrib><description>Restrictive and repetitive behavior in autism may be related to deficits in cognitive control. Here, we aimed to assess functional connectivity during a cognitive control task and compare brain network activity and connectivity in children with autism spectrum disorders (ASD) and typically developing children using a multivariate data-driven approach. 19 high-functioning boys with ASD and 19 age-matched typically developing boys were included in this study. Functional magnetic resonance imaging was performed at 3T during the performance of a cognitive control task (go/no-go paradigm). Functional networks were identified using independent component analysis. Network activity and connectivity was compared between groups and correlated with clinical measures of rigid behavior using multivariate analysis of covariance. We found no differences between the groups in task performance or in network activity. Power analysis indicated that, if this were a real difference, it would require nearly 800 subjects to show group differences in network activity using this paradigm. Neither were there correlations between network activity and rigid behavior. Our data do not provide support for the presence of deficits in cognitive control in children with ASD, or the functional networks supporting this ability.</description><identifier>ISSN: 0300-9564</identifier><identifier>EISSN: 1435-1463</identifier><identifier>DOI: 10.1007/s00702-014-1237-8</identifier><identifier>PMID: 24845879</identifier><identifier>CODEN: JNTRF3</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Adolescent ; Brain - physiopathology ; Brain Mapping ; Child ; Child Development Disorders, Pervasive - physiopathology ; Cognition - physiology ; Executive Function - physiology ; Humans ; Magnetic Resonance Imaging ; Male ; Medicine ; Medicine & Public Health ; Multivariate Analysis ; Neural Pathways - physiopathology ; Neurology ; Neuropsychological Tests ; Neurosciences ; Psychiatry ; Psychiatry and Preclinical Psychiatric Studies - Original ; Psychiatry and Preclinical Psychiatric Studies - Original Article ; Signal Processing, Computer-Assisted</subject><ispartof>Journal of Neural Transmission, 2014-09, Vol.121 (9), p.1145-1155</ispartof><rights>The Author(s) 2014</rights><rights>Springer-Verlag Wien 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-8c02ab43a9a0379684282231070651df11071abd73a60d4c0b7e0499d129a3eb3</citedby><cites>FETCH-LOGICAL-c536t-8c02ab43a9a0379684282231070651df11071abd73a60d4c0b7e0499d129a3eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00702-014-1237-8$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00702-014-1237-8$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24845879$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ambrosino, S.</creatorcontrib><creatorcontrib>Bos, D. J.</creatorcontrib><creatorcontrib>van Raalten, T. R.</creatorcontrib><creatorcontrib>Kobussen, N. A.</creatorcontrib><creatorcontrib>van Belle, J.</creatorcontrib><creatorcontrib>Oranje, B.</creatorcontrib><creatorcontrib>Durston, S.</creatorcontrib><title>Functional connectivity during cognitive control in children with autism spectrum disorder: an independent component analysis</title><title>Journal of Neural Transmission</title><addtitle>J Neural Transm</addtitle><addtitle>J Neural Transm (Vienna)</addtitle><description>Restrictive and repetitive behavior in autism may be related to deficits in cognitive control. Here, we aimed to assess functional connectivity during a cognitive control task and compare brain network activity and connectivity in children with autism spectrum disorders (ASD) and typically developing children using a multivariate data-driven approach. 19 high-functioning boys with ASD and 19 age-matched typically developing boys were included in this study. Functional magnetic resonance imaging was performed at 3T during the performance of a cognitive control task (go/no-go paradigm). Functional networks were identified using independent component analysis. Network activity and connectivity was compared between groups and correlated with clinical measures of rigid behavior using multivariate analysis of covariance. We found no differences between the groups in task performance or in network activity. Power analysis indicated that, if this were a real difference, it would require nearly 800 subjects to show group differences in network activity using this paradigm. Neither were there correlations between network activity and rigid behavior. Our data do not provide support for the presence of deficits in cognitive control in children with ASD, or the functional networks supporting this ability.</description><subject>Adolescent</subject><subject>Brain - physiopathology</subject><subject>Brain Mapping</subject><subject>Child</subject><subject>Child Development Disorders, Pervasive - physiopathology</subject><subject>Cognition - physiology</subject><subject>Executive Function - physiology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multivariate Analysis</subject><subject>Neural Pathways - physiopathology</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Neurosciences</subject><subject>Psychiatry</subject><subject>Psychiatry and Preclinical Psychiatric Studies - Original</subject><subject>Psychiatry and Preclinical Psychiatric Studies - Original Article</subject><subject>Signal Processing, Computer-Assisted</subject><issn>0300-9564</issn><issn>1435-1463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNqNkkGP1SAQx4nRuM_VD-DFNPHipcoAheLBxGxcNdnEi54JLbz32LRQoV3zDn53p-m6WU1MvMAAv_kzMH9CngN9DZSqNwUHymoKogbGVd0-IDsQvKlBSP6Q7CintNaNFGfkSSnXlFIA1T4mZ0y0ommV3pGfl0vs55CiHao-xehxcRPmU-WWHOIB9w4x4JZfT-echirEqj-GwWUfqx9hPlZ2mUMZqzJhbl7GyoWSsvP5bWUj0s5PHoc4o8I4pbhGFq87lVCekkd7OxT_7HY-J98uP3y9-FRfffn4-eL9Vd03XM5121NmO8GttpQrLVvBWsY44OtlA24PGIHtnOJWUid62ilPhdYOmLbcd_ycvNt0p6UbveuxhmwHM-Uw2nwyyQbz50kMR3NIN0aAAK04Cry6Fcjp--LLbMZQej8MNvq0FAONxKq00PI_0KaRTClFEX35F3qdlox_s1FcMdACKdioPqdSst_f1Q3UrD4wmw8M-sCsPjAt5ry4_-C7jN-NR4BtQJnWPvt87-p_qv4Cw5_AFg</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Ambrosino, S.</creator><creator>Bos, D. 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J.</creatorcontrib><creatorcontrib>van Raalten, T. R.</creatorcontrib><creatorcontrib>Kobussen, N. A.</creatorcontrib><creatorcontrib>van Belle, J.</creatorcontrib><creatorcontrib>Oranje, B.</creatorcontrib><creatorcontrib>Durston, S.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Neural Transmission</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ambrosino, S.</au><au>Bos, D. J.</au><au>van Raalten, T. 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| subjects | Adolescent Brain - physiopathology Brain Mapping Child Child Development Disorders, Pervasive - physiopathology Cognition - physiology Executive Function - physiology Humans Magnetic Resonance Imaging Male Medicine Medicine & Public Health Multivariate Analysis Neural Pathways - physiopathology Neurology Neuropsychological Tests Neurosciences Psychiatry Psychiatry and Preclinical Psychiatric Studies - Original Psychiatry and Preclinical Psychiatric Studies - Original Article Signal Processing, Computer-Assisted |
| title | Functional connectivity during cognitive control in children with autism spectrum disorder: an independent component analysis |
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