The C57BL/6J Niemann–Pick C1 mouse model with decreased gene dosage has impaired glucose tolerance independent of body weight

The human Niemann–Pick C1 (NPC1) gene has been found to be associated with extreme (early-onset and morbid-adult) obesity and type 2 diabetes independent of body weight. We previously performed growth studies using BALB/cJ Npc1 normal (Npc1+/+) and Npc1 heterozygous (Npc1+/−) mice and determined tha...

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Veröffentlicht in:	Gene 2013-09, Vol.527 (1), p.65-70
Hauptverfasser:	Jelinek, David, Castillo, Joseph J., Garver, William S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue, White Adipose Tissue, White - metabolism Adipose Tissue, White - pathology Adiposity alanine transaminase animal models Animals blood Blood Glucose Body Weight Cholesterol Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - pathology Disease Models, Animal fatty acid metabolism Female Free fatty acids Gene Dosage Gene Expression genes Genetic Predisposition to Disease genetics Glucose Intolerance Glucose Intolerance - blood Glucose Intolerance - genetics Glucose Intolerance - pathology glucose tolerance Glucose Tolerance Test heterozygosity high fat diet Humans insulin resistance Intracellular Signaling Peptides and Proteins liver Liver - metabolism Liver - pathology Liver X Receptors low fat diet Male metabolism Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Transgenic Muscle, Skeletal Muscle, Skeletal - metabolism Muscle, Skeletal - pathology muscles Niemann–Pick C1 noninsulin-dependent diabetes mellitus Obesity Organ Size Orphan Nuclear Receptors Orphan Nuclear Receptors - genetics Orphan Nuclear Receptors - metabolism pathology PPAR alpha PPAR alpha - genetics PPAR alpha - metabolism Proteins Proteins - genetics Sterol Regulatory Element Binding Protein 1 Sterol Regulatory Element Binding Protein 1 - genetics Sterol Regulatory Element Binding Protein 1 - metabolism Sterol Regulatory Element Binding Protein 2 Sterol Regulatory Element Binding Protein 2 - genetics Sterol Regulatory Element Binding Protein 2 - metabolism Type 2 diabetes weight gain
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