Regulation of the Mammalian Elongation Cycle by Subunit Rolling: A Eukaryotic-Specific Ribosome Rearrangement

The extent to which bacterial ribosomes and the significantly larger eukaryotic ribosomes share the same mechanisms of ribosomal elongation is unknown. Here, we present subnanometer resolution cryoelectron microscopy maps of the mammalian 80S ribosome in the posttranslocational state and in complex...

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Veröffentlicht in:	Cell 2014-07, Vol.158 (1), p.121-131
Hauptverfasser:	Budkevich, Tatyana V., Giesebrecht, Jan, Behrmann, Elmar, Loerke, Justus, Ramrath, David J.F., Mielke, Thorsten, Ismer, Jochen, Hildebrand, Peter W., Tung, Chang-Shung, Nierhaus, Knud H., Sanbonmatsu, Karissa Y., Spahn, Christian M.T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Anticodon - metabolism bacteria Codon - metabolism cryo-electron microscopy Cryoelectron Microscopy Crystallography, X-Ray guanosinetriphosphatase Humans mammals Mammals - metabolism Molecular Sequence Data Peptide Chain Elongation, Translational Rabbits ribosomes Ribosomes - chemistry RNA, Transfer - metabolism Saccharomyces cerevisiae - metabolism Tetrahymena thermophila - metabolism transfer RNA
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