Constitutive induction of pro-inflammatory and chemotactic cytokines in cystathionine beta-synthase deficient homocystinuria

Cystathionine beta-synthase (CBS) deficient homocystinuria (HCU) is an inherited metabolic defect that if untreated, typically results in cognitive impairment, connective tissue disturbances, atherosclerosis and thromboembolic disease. In recent years, chronic inappropriate expression of the inflamm...

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Veröffentlicht in:	Molecular genetics and metabolism 2011-08, Vol.103 (4), p.330-337
Hauptverfasser:	Keating, Amy K., Freehauf, Cynthia, Jiang, Hua, Brodsky, Gary L., Stabler, Sally P., Allen, Robert H., Graham, Douglas K., Thomas, Janet A., Van Hove, Johan L.K., Maclean, Kenneth N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Adolescent Adult Animals Betaine - pharmacology Chemokine CCL4 - metabolism Chemokines - metabolism Child Child, Preschool Cystathionine beta-synthase Cystathionine beta-Synthase - deficiency Cystathionine beta-Synthase - genetics Cystathionine beta-Synthase - metabolism Cytokine Female Homocysteine Homocystinuria Homocystinuria - metabolism Homocystinuria - therapy Humans Interleukin-1 Interleukin-17 - metabolism Interleukin-1alpha - metabolism Interleukin-1beta - metabolism Interleukin-6 - metabolism Male Mice Mice, Transgenic Tumor necrosis factor alpha Tumor Necrosis Factor-alpha - metabolism
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