Donor and Recipient Size Mismatch in Adolescents Undergoing Living-Donor Renal Transplantation Affect Long-Term Graft Survival
BACKGROUNDControversies exist in the adult literature regarding the use of kidneys from small donors into larger recipients. Little is known regarding this issue in pediatric kidney transplantation. To assess the impact of donor/recipient size mismatch on long-term renal graft survival in pediatric...
Gespeichert in:
| Veröffentlicht in: | Transplantation 2013-09, Vol.96 (6), p.555-559 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 559 |
|---|---|
| container_issue | 6 |
| container_start_page | 555 |
| container_title | Transplantation |
| container_volume | 96 |
| creator | Dick, André A.S. Mercer, Laina D. Smith, Jodi M. McDonald, Ruth A. Young, Bessie Healey, Patrick J. |
| description | BACKGROUNDControversies exist in the adult literature regarding the use of kidneys from small donors into larger recipients. Little is known regarding this issue in pediatric kidney transplantation. To assess the impact of donor/recipient size mismatch on long-term renal graft survival in pediatric patients undergoing living-donor renal transplantation.
METHODSWe reviewed the United Network for Organ Sharing database from 1987 to 2010 for adolescent (11–18 years old) patients who underwent primary living-donor renal transplantation. According to donor/recipient body surface area (BSA) ratio, patients were stratified into two categoriesBSA ratio |
| doi_str_mv | 10.1097/TP.0b013e31829d672c |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4141076</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1505339689</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5499-b898a226c7ba20cd88806a933380bd90c03be75032f9aa6c4ffea644de691ae3</originalsourceid><addsrcrecordid>eNqFUk1v1DAQtRCILoVfgIR85JIy_khiX5CqFgrSIqoSzpbjOLsGx17sZCs48NvxaksFXDiN5Hnvzbx5Rug5gTMCsn3VXZ9BD4RZRgSVQ9NS8wCtSM141YCAh2gFwElFGGtP0JOcvwBAzdr2MTqhTDAhpVyhn5cxxIR1GPCNNW7nbJjxJ_fD4g8uT3o2W-wCPh-it9mUXsafw2DTJrqwwWu3L6U6StzYoD3ukg5553WY9exiYY6jNTNex4LrbJrwVdJjmbCkvdtr_xQ9GrXP9tldPUXd2zfdxbtq_fHq_cX5ujI1l7LqhRSa0sa0vaZgBiEENFoyxgT0gwQDrLdtDYyOUuvG8DJVN5wPtpFEW3aKXh9ld0s_2eFgJGmvdslNOn1XUTv1dye4rdrEveKEE2ibIvDyTiDFb4vNs5pcuYcvRm1csiJ1OS2TjZD_h3LOOKENPaiyI9SkmHOy4_1GBNQhY9Vdq38zLqwXf5q55_wOtQD4EXAb_WxT_uqXW5vU1mo_b1X5BdAKCRUtuiBpC9XhSbJfN1u1dA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1443412626</pqid></control><display><type>article</type><title>Donor and Recipient Size Mismatch in Adolescents Undergoing Living-Donor Renal Transplantation Affect Long-Term Graft Survival</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Dick, André A.S. ; Mercer, Laina D. ; Smith, Jodi M. ; McDonald, Ruth A. ; Young, Bessie ; Healey, Patrick J.</creator><creatorcontrib>Dick, André A.S. ; Mercer, Laina D. ; Smith, Jodi M. ; McDonald, Ruth A. ; Young, Bessie ; Healey, Patrick J.</creatorcontrib><description>BACKGROUNDControversies exist in the adult literature regarding the use of kidneys from small donors into larger recipients. Little is known regarding this issue in pediatric kidney transplantation. To assess the impact of donor/recipient size mismatch on long-term renal graft survival in pediatric patients undergoing living-donor renal transplantation.
METHODSWe reviewed the United Network for Organ Sharing database from 1987 to 2010 for adolescent (11–18 years old) patients who underwent primary living-donor renal transplantation. According to donor/recipient body surface area (BSA) ratio, patients were stratified into two categoriesBSA ratio <0.9 and ≥0.9. Graft survival rates were compared between these two groups using Kaplan–Meier survival curves and Cox proportional hazards models.
RESULTSOf the 1880 patients identified, 116 (6.2%) had a donor/recipient BSA ratio <0.9 and 1764 (93.8%) had a donor/recipient BSA ratio ≥0.9 group. BSA ratio <0.9 conferred an increased risk of graft loss (adjusted hazard ratio, 1.61; 95% confidence interval, 1.13–2.27; P=0.008). Patients with a donor/recipient BSA ratio ≥0.9 group had a significantly longer graft survival compared with those with a donor/recipient BSA ratio <0.9 after adjustment for donor age and gender, recipient age, gender, ethnicity, cause of renal failure, as well as clinical factors, such as cold and warm ischemia time and HLA mismatch.
CONCLUSIONWe conclude that low donor/recipient BSA ratio was associated with an increased risk of graft loss. Appropriate size matching conferred better long-term graft survival in adolescents receiving live-donor kidney transplants.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/TP.0b013e31829d672c</identifier><identifier>PMID: 23838999</identifier><language>eng</language><publisher>United States: by Lippincott Williams & Wilkins</publisher><subject>Adolescent ; Adult ; Age Factors ; Body Surface Area ; Child ; Donor Selection ; Female ; Graft Survival ; Humans ; Kaplan-Meier Estimate ; Kidney Transplantation - adverse effects ; Kidney Transplantation - mortality ; Living Donors ; Male ; Middle Aged ; Proportional Hazards Models ; Retrospective Studies ; Risk Factors ; Time Factors ; Tissue and Organ Procurement ; Treatment Outcome ; United States</subject><ispartof>Transplantation, 2013-09, Vol.96 (6), p.555-559</ispartof><rights>2013 by Lippincott Williams & Wilkins</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5499-b898a226c7ba20cd88806a933380bd90c03be75032f9aa6c4ffea644de691ae3</citedby><cites>FETCH-LOGICAL-c5499-b898a226c7ba20cd88806a933380bd90c03be75032f9aa6c4ffea644de691ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23838999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dick, André A.S.</creatorcontrib><creatorcontrib>Mercer, Laina D.</creatorcontrib><creatorcontrib>Smith, Jodi M.</creatorcontrib><creatorcontrib>McDonald, Ruth A.</creatorcontrib><creatorcontrib>Young, Bessie</creatorcontrib><creatorcontrib>Healey, Patrick J.</creatorcontrib><title>Donor and Recipient Size Mismatch in Adolescents Undergoing Living-Donor Renal Transplantation Affect Long-Term Graft Survival</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>BACKGROUNDControversies exist in the adult literature regarding the use of kidneys from small donors into larger recipients. Little is known regarding this issue in pediatric kidney transplantation. To assess the impact of donor/recipient size mismatch on long-term renal graft survival in pediatric patients undergoing living-donor renal transplantation.
METHODSWe reviewed the United Network for Organ Sharing database from 1987 to 2010 for adolescent (11–18 years old) patients who underwent primary living-donor renal transplantation. According to donor/recipient body surface area (BSA) ratio, patients were stratified into two categoriesBSA ratio <0.9 and ≥0.9. Graft survival rates were compared between these two groups using Kaplan–Meier survival curves and Cox proportional hazards models.
RESULTSOf the 1880 patients identified, 116 (6.2%) had a donor/recipient BSA ratio <0.9 and 1764 (93.8%) had a donor/recipient BSA ratio ≥0.9 group. BSA ratio <0.9 conferred an increased risk of graft loss (adjusted hazard ratio, 1.61; 95% confidence interval, 1.13–2.27; P=0.008). Patients with a donor/recipient BSA ratio ≥0.9 group had a significantly longer graft survival compared with those with a donor/recipient BSA ratio <0.9 after adjustment for donor age and gender, recipient age, gender, ethnicity, cause of renal failure, as well as clinical factors, such as cold and warm ischemia time and HLA mismatch.
CONCLUSIONWe conclude that low donor/recipient BSA ratio was associated with an increased risk of graft loss. Appropriate size matching conferred better long-term graft survival in adolescents receiving live-donor kidney transplants.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Body Surface Area</subject><subject>Child</subject><subject>Donor Selection</subject><subject>Female</subject><subject>Graft Survival</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Kidney Transplantation - mortality</subject><subject>Living Donors</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Proportional Hazards Models</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>Tissue and Organ Procurement</subject><subject>Treatment Outcome</subject><subject>United States</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUk1v1DAQtRCILoVfgIR85JIy_khiX5CqFgrSIqoSzpbjOLsGx17sZCs48NvxaksFXDiN5Hnvzbx5Rug5gTMCsn3VXZ9BD4RZRgSVQ9NS8wCtSM141YCAh2gFwElFGGtP0JOcvwBAzdr2MTqhTDAhpVyhn5cxxIR1GPCNNW7nbJjxJ_fD4g8uT3o2W-wCPh-it9mUXsafw2DTJrqwwWu3L6U6StzYoD3ukg5553WY9exiYY6jNTNex4LrbJrwVdJjmbCkvdtr_xQ9GrXP9tldPUXd2zfdxbtq_fHq_cX5ujI1l7LqhRSa0sa0vaZgBiEENFoyxgT0gwQDrLdtDYyOUuvG8DJVN5wPtpFEW3aKXh9ld0s_2eFgJGmvdslNOn1XUTv1dye4rdrEveKEE2ibIvDyTiDFb4vNs5pcuYcvRm1csiJ1OS2TjZD_h3LOOKENPaiyI9SkmHOy4_1GBNQhY9Vdq38zLqwXf5q55_wOtQD4EXAb_WxT_uqXW5vU1mo_b1X5BdAKCRUtuiBpC9XhSbJfN1u1dA</recordid><startdate>201309</startdate><enddate>201309</enddate><creator>Dick, André A.S.</creator><creator>Mercer, Laina D.</creator><creator>Smith, Jodi M.</creator><creator>McDonald, Ruth A.</creator><creator>Young, Bessie</creator><creator>Healey, Patrick J.</creator><general>by Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>201309</creationdate><title>Donor and Recipient Size Mismatch in Adolescents Undergoing Living-Donor Renal Transplantation Affect Long-Term Graft Survival</title><author>Dick, André A.S. ; Mercer, Laina D. ; Smith, Jodi M. ; McDonald, Ruth A. ; Young, Bessie ; Healey, Patrick J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5499-b898a226c7ba20cd88806a933380bd90c03be75032f9aa6c4ffea644de691ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Body Surface Area</topic><topic>Child</topic><topic>Donor Selection</topic><topic>Female</topic><topic>Graft Survival</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Kidney Transplantation - mortality</topic><topic>Living Donors</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Proportional Hazards Models</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>Tissue and Organ Procurement</topic><topic>Treatment Outcome</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dick, André A.S.</creatorcontrib><creatorcontrib>Mercer, Laina D.</creatorcontrib><creatorcontrib>Smith, Jodi M.</creatorcontrib><creatorcontrib>McDonald, Ruth A.</creatorcontrib><creatorcontrib>Young, Bessie</creatorcontrib><creatorcontrib>Healey, Patrick J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dick, André A.S.</au><au>Mercer, Laina D.</au><au>Smith, Jodi M.</au><au>McDonald, Ruth A.</au><au>Young, Bessie</au><au>Healey, Patrick J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Donor and Recipient Size Mismatch in Adolescents Undergoing Living-Donor Renal Transplantation Affect Long-Term Graft Survival</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>2013-09</date><risdate>2013</risdate><volume>96</volume><issue>6</issue><spage>555</spage><epage>559</epage><pages>555-559</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><abstract>BACKGROUNDControversies exist in the adult literature regarding the use of kidneys from small donors into larger recipients. Little is known regarding this issue in pediatric kidney transplantation. To assess the impact of donor/recipient size mismatch on long-term renal graft survival in pediatric patients undergoing living-donor renal transplantation.
METHODSWe reviewed the United Network for Organ Sharing database from 1987 to 2010 for adolescent (11–18 years old) patients who underwent primary living-donor renal transplantation. According to donor/recipient body surface area (BSA) ratio, patients were stratified into two categoriesBSA ratio <0.9 and ≥0.9. Graft survival rates were compared between these two groups using Kaplan–Meier survival curves and Cox proportional hazards models.
RESULTSOf the 1880 patients identified, 116 (6.2%) had a donor/recipient BSA ratio <0.9 and 1764 (93.8%) had a donor/recipient BSA ratio ≥0.9 group. BSA ratio <0.9 conferred an increased risk of graft loss (adjusted hazard ratio, 1.61; 95% confidence interval, 1.13–2.27; P=0.008). Patients with a donor/recipient BSA ratio ≥0.9 group had a significantly longer graft survival compared with those with a donor/recipient BSA ratio <0.9 after adjustment for donor age and gender, recipient age, gender, ethnicity, cause of renal failure, as well as clinical factors, such as cold and warm ischemia time and HLA mismatch.
CONCLUSIONWe conclude that low donor/recipient BSA ratio was associated with an increased risk of graft loss. Appropriate size matching conferred better long-term graft survival in adolescents receiving live-donor kidney transplants.</abstract><cop>United States</cop><pub>by Lippincott Williams & Wilkins</pub><pmid>23838999</pmid><doi>10.1097/TP.0b013e31829d672c</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-1337 |
| ispartof | Transplantation, 2013-09, Vol.96 (6), p.555-559 |
| issn | 0041-1337 1534-6080 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4141076 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult Age Factors Body Surface Area Child Donor Selection Female Graft Survival Humans Kaplan-Meier Estimate Kidney Transplantation - adverse effects Kidney Transplantation - mortality Living Donors Male Middle Aged Proportional Hazards Models Retrospective Studies Risk Factors Time Factors Tissue and Organ Procurement Treatment Outcome United States |
| title | Donor and Recipient Size Mismatch in Adolescents Undergoing Living-Donor Renal Transplantation Affect Long-Term Graft Survival |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T06%3A51%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Donor%20and%20Recipient%20Size%20Mismatch%20in%20Adolescents%20Undergoing%20Living-Donor%20Renal%20Transplantation%20Affect%20Long-Term%20Graft%20Survival&rft.jtitle=Transplantation&rft.au=Dick,%20Andr%C3%A9%20A.S.&rft.date=2013-09&rft.volume=96&rft.issue=6&rft.spage=555&rft.epage=559&rft.pages=555-559&rft.issn=0041-1337&rft.eissn=1534-6080&rft_id=info:doi/10.1097/TP.0b013e31829d672c&rft_dat=%3Cproquest_pubme%3E1505339689%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1443412626&rft_id=info:pmid/23838999&rfr_iscdi=true |