Diet and proinflammatory cytokine levels in head and neck squamous cell carcinoma
BACKGROUND Proinflammatory cytokine levels may be associated with cancer stage, recurrence, and survival. The objective of this study was to determine whether cytokine levels were associated with dietary patterns and fat‐soluble micronutrients in patients with previously untreated head and neck squa...
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| Veröffentlicht in: | Cancer 2014-09, Vol.120 (17), p.2704-2712 |
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| creator | Arthur, Anna E. Peterson, Karen E. Shen, Jincheng Djuric, Zora Taylor, Jeremy M. G. Hebert, James R. Duffy, Sonia A. Peterson, Lisa A. Bellile, Emily L. Whitfield, Joel R. Chepeha, Douglas B. Schipper, Matthew J. Wolf, Gregory T. Rozek, Laura S. |
| description | BACKGROUND
Proinflammatory cytokine levels may be associated with cancer stage, recurrence, and survival. The objective of this study was to determine whether cytokine levels were associated with dietary patterns and fat‐soluble micronutrients in patients with previously untreated head and neck squamous cell carcinoma (HNSCC).
METHODS
This was a cross‐sectional study of 160 patients with newly diagnosed HNSCC who completed pretreatment food frequency questionnaires (FFQs) and health surveys. Dietary patterns were derived from FFQs using principal component analysis. Pretreatment serum levels of the proinflammatory cytokines interleukin‐6 (IL‐6), tumor necrosis factor alpha (TNF‐α), and interferon gamma (IFN‐γ) were measured using an enzyme‐linked immunosorbent assay, and serum carotenoid and tocopherol levels were measured by high‐performance liquid chromatography. Multivariable ordinal logistic regression models examined associations between cytokines and quartiles of reported and serum dietary variables.
RESULTS
Three dietary patterns emerged: whole foods, Western, and convenience foods. In multivariable analyses, higher whole foods pattern scores were significantly associated with lower levels of IL‐6, TNF‐α, and IFN‐γ (P ≤ .001, P = .008, and P = .03, respectively). Significant inverse associations were reported between IL‐6, TNF‐α, and IFN‐γ levels and quartiles of total reported carotenoid intake (P = .006, P = .04, and P = .04, respectively). There was an inverse association between IFN‐γ levels and serum α‐tocopherol levels (P = .03).
CONCLUSIONS
Consuming a pretreatment diet rich in vegetables, fruit, fish, poultry, and whole grains may be associated with lower proinflammatory cytokine levels in patients with HNSCC. Cancer 2014;120:2704–2712. © 2014 American Cancer Society.
Consuming a pretreatment diet rich in vegetables, fruit, fish, poultry, and whole grains may be associated with lower proinflammatory cytokine levels in patients with head and neck cancer. |
| doi_str_mv | 10.1002/cncr.28778 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4141000</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1566846187</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5538-cb6f5b0841bdf99f9fea73b23612cbf2eb33ecc2da7c3c99c2ea44e40838aa4f3</originalsourceid><addsrcrecordid>eNp9kU9rFEEQxRsxmE304geQuQgiTNL_ZrrnIoTVaCBEFAVvTU1NtWkz07Ppno3st3c2u0a9eCqK-vFeVT3Gngt-IjiXpxgxnUhrjH3EFoI3puRCy8dswTm3ZaXVt0N2lPOPuTWyUk_YodRWcVOLBfv0NtBUQOyKVRpD9D0MA0xj2hS4mcabEKno6Y76XIRYXBN092wkvCny7RqGcZ0LpL4vEBKGOA7wlB146DM929dj9vX83Zflh_Ly4_uL5dlliVWlbIlt7auWWy3azjeNbzyBUa1UtZDYekmtUoQoOzCosGlQEmhNmltlAbRXx-zNTne1bgfqkOKUoHerFAZIGzdCcP9OYrh238c7p4We38ZngVd7gTTerilPbgh5ewtEms9yoqprq2thzYy-3qGYxpwT-Qcbwd02A7fNwN1nMMMv_l7sAf399Bl4uQcgI_Q-QcSQ_3DWaFOb7YJix_0MPW3-Y-mWV8vPO_Nf_dehbg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1566846187</pqid></control><display><type>article</type><title>Diet and proinflammatory cytokine levels in head and neck squamous cell carcinoma</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Arthur, Anna E. ; Peterson, Karen E. ; Shen, Jincheng ; Djuric, Zora ; Taylor, Jeremy M. G. ; Hebert, James R. ; Duffy, Sonia A. ; Peterson, Lisa A. ; Bellile, Emily L. ; Whitfield, Joel R. ; Chepeha, Douglas B. ; Schipper, Matthew J. ; Wolf, Gregory T. ; Rozek, Laura S.</creator><creatorcontrib>Arthur, Anna E. ; Peterson, Karen E. ; Shen, Jincheng ; Djuric, Zora ; Taylor, Jeremy M. G. ; Hebert, James R. ; Duffy, Sonia A. ; Peterson, Lisa A. ; Bellile, Emily L. ; Whitfield, Joel R. ; Chepeha, Douglas B. ; Schipper, Matthew J. ; Wolf, Gregory T. ; Rozek, Laura S.</creatorcontrib><description>BACKGROUND
Proinflammatory cytokine levels may be associated with cancer stage, recurrence, and survival. The objective of this study was to determine whether cytokine levels were associated with dietary patterns and fat‐soluble micronutrients in patients with previously untreated head and neck squamous cell carcinoma (HNSCC).
METHODS
This was a cross‐sectional study of 160 patients with newly diagnosed HNSCC who completed pretreatment food frequency questionnaires (FFQs) and health surveys. Dietary patterns were derived from FFQs using principal component analysis. Pretreatment serum levels of the proinflammatory cytokines interleukin‐6 (IL‐6), tumor necrosis factor alpha (TNF‐α), and interferon gamma (IFN‐γ) were measured using an enzyme‐linked immunosorbent assay, and serum carotenoid and tocopherol levels were measured by high‐performance liquid chromatography. Multivariable ordinal logistic regression models examined associations between cytokines and quartiles of reported and serum dietary variables.
RESULTS
Three dietary patterns emerged: whole foods, Western, and convenience foods. In multivariable analyses, higher whole foods pattern scores were significantly associated with lower levels of IL‐6, TNF‐α, and IFN‐γ (P ≤ .001, P = .008, and P = .03, respectively). Significant inverse associations were reported between IL‐6, TNF‐α, and IFN‐γ levels and quartiles of total reported carotenoid intake (P = .006, P = .04, and P = .04, respectively). There was an inverse association between IFN‐γ levels and serum α‐tocopherol levels (P = .03).
CONCLUSIONS
Consuming a pretreatment diet rich in vegetables, fruit, fish, poultry, and whole grains may be associated with lower proinflammatory cytokine levels in patients with HNSCC. Cancer 2014;120:2704–2712. © 2014 American Cancer Society.
Consuming a pretreatment diet rich in vegetables, fruit, fish, poultry, and whole grains may be associated with lower proinflammatory cytokine levels in patients with head and neck cancer.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.28778</identifier><identifier>PMID: 24830761</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>Hoboken, NJ: Wiley-Blackwell</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers, Tumor - blood ; Carcinoma, Squamous Cell - blood ; carotenoids ; Cross-Sectional Studies ; cytokines ; Cytokines - blood ; Diet ; dietary patterns ; Female ; head and neck cancer ; Head and Neck Neoplasms - blood ; Humans ; Inflammation Mediators - blood ; Male ; Medical sciences ; Middle Aged ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Multivariate Analysis ; Odds Ratio ; Otorhinolaryngology (head neck, general aspects and miscellaneous) ; Otorhinolaryngology. Stomatology ; Squamous Cell Carcinoma of Head and Neck ; Tumors</subject><ispartof>Cancer, 2014-09, Vol.120 (17), p.2704-2712</ispartof><rights>2014 American Cancer Society</rights><rights>2015 INIST-CNRS</rights><rights>2014 American Cancer Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5538-cb6f5b0841bdf99f9fea73b23612cbf2eb33ecc2da7c3c99c2ea44e40838aa4f3</citedby><cites>FETCH-LOGICAL-c5538-cb6f5b0841bdf99f9fea73b23612cbf2eb33ecc2da7c3c99c2ea44e40838aa4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.28778$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.28778$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28747670$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24830761$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arthur, Anna E.</creatorcontrib><creatorcontrib>Peterson, Karen E.</creatorcontrib><creatorcontrib>Shen, Jincheng</creatorcontrib><creatorcontrib>Djuric, Zora</creatorcontrib><creatorcontrib>Taylor, Jeremy M. G.</creatorcontrib><creatorcontrib>Hebert, James R.</creatorcontrib><creatorcontrib>Duffy, Sonia A.</creatorcontrib><creatorcontrib>Peterson, Lisa A.</creatorcontrib><creatorcontrib>Bellile, Emily L.</creatorcontrib><creatorcontrib>Whitfield, Joel R.</creatorcontrib><creatorcontrib>Chepeha, Douglas B.</creatorcontrib><creatorcontrib>Schipper, Matthew J.</creatorcontrib><creatorcontrib>Wolf, Gregory T.</creatorcontrib><creatorcontrib>Rozek, Laura S.</creatorcontrib><title>Diet and proinflammatory cytokine levels in head and neck squamous cell carcinoma</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND
Proinflammatory cytokine levels may be associated with cancer stage, recurrence, and survival. The objective of this study was to determine whether cytokine levels were associated with dietary patterns and fat‐soluble micronutrients in patients with previously untreated head and neck squamous cell carcinoma (HNSCC).
METHODS
This was a cross‐sectional study of 160 patients with newly diagnosed HNSCC who completed pretreatment food frequency questionnaires (FFQs) and health surveys. Dietary patterns were derived from FFQs using principal component analysis. Pretreatment serum levels of the proinflammatory cytokines interleukin‐6 (IL‐6), tumor necrosis factor alpha (TNF‐α), and interferon gamma (IFN‐γ) were measured using an enzyme‐linked immunosorbent assay, and serum carotenoid and tocopherol levels were measured by high‐performance liquid chromatography. Multivariable ordinal logistic regression models examined associations between cytokines and quartiles of reported and serum dietary variables.
RESULTS
Three dietary patterns emerged: whole foods, Western, and convenience foods. In multivariable analyses, higher whole foods pattern scores were significantly associated with lower levels of IL‐6, TNF‐α, and IFN‐γ (P ≤ .001, P = .008, and P = .03, respectively). Significant inverse associations were reported between IL‐6, TNF‐α, and IFN‐γ levels and quartiles of total reported carotenoid intake (P = .006, P = .04, and P = .04, respectively). There was an inverse association between IFN‐γ levels and serum α‐tocopherol levels (P = .03).
CONCLUSIONS
Consuming a pretreatment diet rich in vegetables, fruit, fish, poultry, and whole grains may be associated with lower proinflammatory cytokine levels in patients with HNSCC. Cancer 2014;120:2704–2712. © 2014 American Cancer Society.
Consuming a pretreatment diet rich in vegetables, fruit, fish, poultry, and whole grains may be associated with lower proinflammatory cytokine levels in patients with head and neck cancer.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - blood</subject><subject>Carcinoma, Squamous Cell - blood</subject><subject>carotenoids</subject><subject>Cross-Sectional Studies</subject><subject>cytokines</subject><subject>Cytokines - blood</subject><subject>Diet</subject><subject>dietary patterns</subject><subject>Female</subject><subject>head and neck cancer</subject><subject>Head and Neck Neoplasms - blood</subject><subject>Humans</subject><subject>Inflammation Mediators - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Multivariate Analysis</subject><subject>Odds Ratio</subject><subject>Otorhinolaryngology (head neck, general aspects and miscellaneous)</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Squamous Cell Carcinoma of Head and Neck</subject><subject>Tumors</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9rFEEQxRsxmE304geQuQgiTNL_ZrrnIoTVaCBEFAVvTU1NtWkz07Ppno3st3c2u0a9eCqK-vFeVT3Gngt-IjiXpxgxnUhrjH3EFoI3puRCy8dswTm3ZaXVt0N2lPOPuTWyUk_YodRWcVOLBfv0NtBUQOyKVRpD9D0MA0xj2hS4mcabEKno6Y76XIRYXBN092wkvCny7RqGcZ0LpL4vEBKGOA7wlB146DM929dj9vX83Zflh_Ly4_uL5dlliVWlbIlt7auWWy3azjeNbzyBUa1UtZDYekmtUoQoOzCosGlQEmhNmltlAbRXx-zNTne1bgfqkOKUoHerFAZIGzdCcP9OYrh238c7p4We38ZngVd7gTTerilPbgh5ewtEms9yoqprq2thzYy-3qGYxpwT-Qcbwd02A7fNwN1nMMMv_l7sAf399Bl4uQcgI_Q-QcSQ_3DWaFOb7YJix_0MPW3-Y-mWV8vPO_Nf_dehbg</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Arthur, Anna E.</creator><creator>Peterson, Karen E.</creator><creator>Shen, Jincheng</creator><creator>Djuric, Zora</creator><creator>Taylor, Jeremy M. G.</creator><creator>Hebert, James R.</creator><creator>Duffy, Sonia A.</creator><creator>Peterson, Lisa A.</creator><creator>Bellile, Emily L.</creator><creator>Whitfield, Joel R.</creator><creator>Chepeha, Douglas B.</creator><creator>Schipper, Matthew J.</creator><creator>Wolf, Gregory T.</creator><creator>Rozek, Laura S.</creator><general>Wiley-Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20140901</creationdate><title>Diet and proinflammatory cytokine levels in head and neck squamous cell carcinoma</title><author>Arthur, Anna E. ; Peterson, Karen E. ; Shen, Jincheng ; Djuric, Zora ; Taylor, Jeremy M. G. ; Hebert, James R. ; Duffy, Sonia A. ; Peterson, Lisa A. ; Bellile, Emily L. ; Whitfield, Joel R. ; Chepeha, Douglas B. ; Schipper, Matthew J. ; Wolf, Gregory T. ; Rozek, Laura S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5538-cb6f5b0841bdf99f9fea73b23612cbf2eb33ecc2da7c3c99c2ea44e40838aa4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - blood</topic><topic>Carcinoma, Squamous Cell - blood</topic><topic>carotenoids</topic><topic>Cross-Sectional Studies</topic><topic>cytokines</topic><topic>Cytokines - blood</topic><topic>Diet</topic><topic>dietary patterns</topic><topic>Female</topic><topic>head and neck cancer</topic><topic>Head and Neck Neoplasms - blood</topic><topic>Humans</topic><topic>Inflammation Mediators - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>Multivariate Analysis</topic><topic>Odds Ratio</topic><topic>Otorhinolaryngology (head neck, general aspects and miscellaneous)</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Squamous Cell Carcinoma of Head and Neck</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arthur, Anna E.</creatorcontrib><creatorcontrib>Peterson, Karen E.</creatorcontrib><creatorcontrib>Shen, Jincheng</creatorcontrib><creatorcontrib>Djuric, Zora</creatorcontrib><creatorcontrib>Taylor, Jeremy M. G.</creatorcontrib><creatorcontrib>Hebert, James R.</creatorcontrib><creatorcontrib>Duffy, Sonia A.</creatorcontrib><creatorcontrib>Peterson, Lisa A.</creatorcontrib><creatorcontrib>Bellile, Emily L.</creatorcontrib><creatorcontrib>Whitfield, Joel R.</creatorcontrib><creatorcontrib>Chepeha, Douglas B.</creatorcontrib><creatorcontrib>Schipper, Matthew J.</creatorcontrib><creatorcontrib>Wolf, Gregory T.</creatorcontrib><creatorcontrib>Rozek, Laura S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arthur, Anna E.</au><au>Peterson, Karen E.</au><au>Shen, Jincheng</au><au>Djuric, Zora</au><au>Taylor, Jeremy M. G.</au><au>Hebert, James R.</au><au>Duffy, Sonia A.</au><au>Peterson, Lisa A.</au><au>Bellile, Emily L.</au><au>Whitfield, Joel R.</au><au>Chepeha, Douglas B.</au><au>Schipper, Matthew J.</au><au>Wolf, Gregory T.</au><au>Rozek, Laura S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diet and proinflammatory cytokine levels in head and neck squamous cell carcinoma</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>120</volume><issue>17</issue><spage>2704</spage><epage>2712</epage><pages>2704-2712</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND
Proinflammatory cytokine levels may be associated with cancer stage, recurrence, and survival. The objective of this study was to determine whether cytokine levels were associated with dietary patterns and fat‐soluble micronutrients in patients with previously untreated head and neck squamous cell carcinoma (HNSCC).
METHODS
This was a cross‐sectional study of 160 patients with newly diagnosed HNSCC who completed pretreatment food frequency questionnaires (FFQs) and health surveys. Dietary patterns were derived from FFQs using principal component analysis. Pretreatment serum levels of the proinflammatory cytokines interleukin‐6 (IL‐6), tumor necrosis factor alpha (TNF‐α), and interferon gamma (IFN‐γ) were measured using an enzyme‐linked immunosorbent assay, and serum carotenoid and tocopherol levels were measured by high‐performance liquid chromatography. Multivariable ordinal logistic regression models examined associations between cytokines and quartiles of reported and serum dietary variables.
RESULTS
Three dietary patterns emerged: whole foods, Western, and convenience foods. In multivariable analyses, higher whole foods pattern scores were significantly associated with lower levels of IL‐6, TNF‐α, and IFN‐γ (P ≤ .001, P = .008, and P = .03, respectively). Significant inverse associations were reported between IL‐6, TNF‐α, and IFN‐γ levels and quartiles of total reported carotenoid intake (P = .006, P = .04, and P = .04, respectively). There was an inverse association between IFN‐γ levels and serum α‐tocopherol levels (P = .03).
CONCLUSIONS
Consuming a pretreatment diet rich in vegetables, fruit, fish, poultry, and whole grains may be associated with lower proinflammatory cytokine levels in patients with HNSCC. Cancer 2014;120:2704–2712. © 2014 American Cancer Society.
Consuming a pretreatment diet rich in vegetables, fruit, fish, poultry, and whole grains may be associated with lower proinflammatory cytokine levels in patients with head and neck cancer.</abstract><cop>Hoboken, NJ</cop><pub>Wiley-Blackwell</pub><pmid>24830761</pmid><doi>10.1002/cncr.28778</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor - blood Carcinoma, Squamous Cell - blood carotenoids Cross-Sectional Studies cytokines Cytokines - blood Diet dietary patterns Female head and neck cancer Head and Neck Neoplasms - blood Humans Inflammation Mediators - blood Male Medical sciences Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Multivariate Analysis Odds Ratio Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Squamous Cell Carcinoma of Head and Neck Tumors |
| title | Diet and proinflammatory cytokine levels in head and neck squamous cell carcinoma |
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