PCTAIRE Kinase 3/Cyclin-dependent Kinase 18 Is Activated through Association with Cyclin A and/or Phosphorylation by Protein Kinase A

PCTAIRE kinase 3 (PCTK3)/cyclin-dependent kinase 18 (CDK18) is an uncharacterized member of the CDK family because its activator(s) remains unidentified. Here we describe the mechanisms of catalytic activation of PCTK3 by cyclin A2 and cAMP-dependent protein kinase (PKA). Using a pulldown experiment...

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Veröffentlicht in:	The Journal of biological chemistry 2014-06, Vol.289 (26), p.18387-18400
Hauptverfasser:	Matsuda, Shinya, Kominato, Kyohei, Koide-Yoshida, Shizuyo, Miyamoto, Kenji, Isshiki, Kinuka, Tsuji, Akihiko, Yuasa, Keizo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cofilin Cyclic AMP-Dependent Protein Kinase Catalytic Subunits - genetics Cyclic AMP-Dependent Protein Kinase Catalytic Subunits - metabolism Cyclin Cyclin A2 - genetics Cyclin A2 - metabolism Cyclin-dependent Kinase (CDK) Cyclin-Dependent Kinases - genetics Cyclin-Dependent Kinases - metabolism Cytoskeleton Enzyme Activation Gene Expression Regulation, Enzymologic Humans Mice Phosphorylation Protein Binding Protein Kinase A (PKA) Signal Transduction
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