Insulin Receptor Substrate 2-mediated Phosphatidylinositol 3-kinase Signaling Selectively Inhibits Glycogen Synthase Kinase 3β to Regulate Aerobic Glycolysis

Insulin receptor substrate 1 (IRS-1) and IRS-2 are cytoplasmic adaptor proteins that mediate the activation of signaling pathways in response to ligand stimulation of upstream cell surface receptors. Despite sharing a high level of homology and the ability to activate PI3K, only Irs-2 positively reg...

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Veröffentlicht in:	The Journal of biological chemistry 2014-06, Vol.289 (26), p.18603-18613
Hauptverfasser:	Landis, Justine, Shaw, Leslie M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Protein Akt Amino Acid Motifs Animals Biological Transport Breast Cancer Breast Neoplasms - enzymology Breast Neoplasms - genetics Breast Neoplasms - metabolism Down-Regulation Female Glucose - metabolism Glut1 Glycogen Synthase Kinase 3 (Gsk-3) Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Glycolysis Humans Insulin Receptor Substrate Proteins - chemistry Insulin Receptor Substrate Proteins - genetics Insulin Receptor Substrate Proteins - metabolism Insulin-like Growth Factor (IGF) IRS-2 Lactic Acid - metabolism Mice Mice, Knockout Phosphatidylinositol 3-Kinase - chemistry Phosphatidylinositol 3-Kinase - genetics Phosphatidylinositol 3-Kinase - metabolism Phosphorylation PI3K Protein Binding Proto-Oncogene Proteins c-akt - metabolism Signal Transduction Tumor Cells, Cultured
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