Ras Promotes Transforming Growth Factor-β (TGF-β)-induced Epithelial-Mesenchymal Transition via a Leukotriene B4 Receptor-2-linked Cascade in Mammary Epithelial Cells

Inflammation and inflammatory mediators are inextricably linked with epithelial-mesenchymal transition (EMT) through complex pathways in the tumor microenvironment. However, the mechanism by which inflammatory mediators, such as the lipid inflammatory mediators, eicosanoids, contribute to EMT is lar...

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Veröffentlicht in:	The Journal of biological chemistry 2014-08, Vol.289 (32), p.22151-22160
Hauptverfasser:	Kim, Hyunju, Choi, Jung-A, Kim, Jae-Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms - etiology Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line Epithelial-Mesenchymal Transition - drug effects Epithelial-Mesenchymal Transition - physiology Female Humans Mammary Glands, Human - cytology Mammary Glands, Human - drug effects Mammary Glands, Human - metabolism NADPH Oxidase 1 NADPH Oxidases - metabolism NF-kappa B - metabolism Proto-Oncogene Proteins p21(ras) - genetics Proto-Oncogene Proteins p21(ras) - metabolism Reactive Oxygen Species - metabolism Receptors, Leukotriene B4 - antagonists & inhibitors Receptors, Leukotriene B4 - genetics Receptors, Leukotriene B4 - metabolism RNA, Small Interfering - genetics Signal Transduction Tetrazoles - pharmacology Transforming Growth Factor beta - metabolism
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