Deficiency of the NR4A Orphan Nuclear Receptor NOR1 in Hematopoietic Stem Cells Accelerates Atherosclerosis

The NR4A orphan nuclear receptor NOR1 functions as a constitutively active transcription factor regulating cellular inflammation and proliferation. In this study, we used bone marrow transplantation to determine the selective contribution of NOR1 expression in hematopoietic stem cells to the develop...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2014-09, Vol.32 (9), p.2419-2429
Hauptverfasser:	Qing, Hua, Liu, Yi, Zhao, Yue, Aono, Jun, Jones, Karrie L., Heywood, Elizabeth B., Howatt, Deborah, Binkley, Cassi M., Daugherty, Alan, Liang, Ying, Bruemmer, Dennis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis Bone marrow Cell Proliferation - physiology Cells, Cultured DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Female HEK293 Cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Humans Macrophage and dendritic progenitors Male Mice Mice, Inbred C57BL Mice, Transgenic Monocyte Monocytes - metabolism Nerve Tissue Proteins - deficiency Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nuclear receptor Plaque, Atherosclerotic - genetics Plaque, Atherosclerotic - metabolism Plaque, Atherosclerotic - pathology Receptors, Steroid - deficiency Receptors, Steroid - genetics Receptors, Steroid - metabolism Receptors, Thyroid Hormone - deficiency Receptors, Thyroid Hormone - genetics Receptors, Thyroid Hormone - metabolism Stem cells Transfection Transplants & implants
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