A role for the ITAM signaling module in specifying cytokine-receptor functions

How the generation of outcomes specific to external cues is achieved by a small number of signal-transduction pathways remains unclear. Medzhitov and colleagues describe a mechanism for signal integration based on coupling of the ITAM and Jak-STAT signaling pathways. Diverse cellular responses to ex...

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Veröffentlicht in:	Nature immunology 2014-04, Vol.15 (4), p.333-342
Hauptverfasser:	Bezbradica, Jelena S, Rosenstein, Rachel K, DeMarco, Richard A, Brodsky, Igor, Medzhitov, Ruslan
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/127 Animals Bacterial Load Biomedicine Cell receptors Cells, Cultured Cellular control mechanisms Cytokines Immunoglobulin Fc Fragments - genetics Immunoglobulin Fc Fragments - metabolism Immunology Immunoreceptor Tyrosine-Based Activation Motif - genetics Immunoreceptor Tyrosine-Based Activation Motif - immunology Infectious Diseases Interferon gamma Receptor Interferon-gamma - immunology Interferon-gamma - metabolism Janus Kinase 2 - genetics Janus Kinase 2 - metabolism Listeriosis - immunology Macrophages - immunology Mice Mice, Inbred Strains Mice, Knockout Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Phagocytosis - genetics Phosphoinositide-3 Kinase Inhibitors Physiological research Properties Protein Engineering Receptor Cross-Talk - immunology Receptors, IgG - genetics Receptors, IgG - metabolism Receptors, Interferon - metabolism Signal Transduction - drug effects Signal Transduction - genetics STAT1 Transcription Factor - genetics STAT1 Transcription Factor - metabolism Transcriptional Activation - drug effects
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