Exposure of mice to chronic hypoxia attenuates pulmonary arterial contractile responses to acute hypoxia by increases in extracellular hydrogen peroxide

Exposing mice to a chronic hypoxic treatment (10% oxygen, 21 days) that promotes pulmonary hypertension was observed to attenuate the pulmonary vasoconstriction response to acute hypoxia (HPV) both in vivo and in isolated pulmonary arteries. Since catalase restored the HPV response in isolated arter...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2014-08, Vol.307 (4), p.R426-R433
Hauptverfasser:	Patel, Dhara, Alhawaj, Raed, Wolin, Michael S
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Aminolevulinic Acid - pharmacology Animals Antihypertensive Agents - pharmacology Aorta - metabolism Aorta - physiopathology Cardiovascular and Renal Integration Cell Adhesion Molecules - metabolism Chronic Disease Cyclic GMP - metabolism Cyclic GMP-Dependent Protein Kinases - metabolism Disease Models, Animal Enzyme Activation Familial Primary Pulmonary Hypertension Hydrogen peroxide Hydrogen Peroxide - metabolism Hypertension, Pulmonary - etiology Hypertension, Pulmonary - metabolism Hypertension, Pulmonary - physiopathology Hypertension, Pulmonary - prevention & control Hypoxia Hypoxia - complications Hypoxia - drug therapy Hypoxia - metabolism Hypoxia - physiopathology Kinases Male Mice Mice, Inbred C57BL Microfilament Proteins - metabolism Phosphoproteins - metabolism Phosphorylation Protoporphyrins - metabolism Pulmonary Artery - drug effects Pulmonary Artery - metabolism Pulmonary Artery - physiopathology Respiration Rodents Superoxide Dismutase - metabolism Superoxides - metabolism Time Factors Up-Regulation Vasoconstriction - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!