Sex differences with aging in nutritive skeletal muscle blood flow: impact of exercise training, nitric oxide, and α-adrenergic-mediated mechanisms
The incidence of cardiovascular disease increases progressively with age, but aging may affect men and women differently. Age-associated changes in vascular structure and function may manifest in impaired nutritive blood flow, although the regulation of nutritive blood flow in healthy aging is not w...
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| Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 2014-08, Vol.307 (4), p.H524-H532 |
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| creator | La Favor, Justin D Kraus, Raymond M Carrithers, Jonathan A Roseno, Steven L Gavin, Timothy P Hickner, Robert C |
| description | The incidence of cardiovascular disease increases progressively with age, but aging may affect men and women differently. Age-associated changes in vascular structure and function may manifest in impaired nutritive blood flow, although the regulation of nutritive blood flow in healthy aging is not well understood. The purpose of this study was to determine if nitric oxide (NO)-mediated or α-adrenergic-mediated regulation of nutritive skeletal muscle blood flow is impaired with advanced age, and if exercise training improves age-related deficiencies. Nutritive blood flow was monitored in the vastus lateralis of healthy young and aged men and women via the microdialysis-ethanol technique prior to and following seven consecutive days of exercise training. NO-mediated and α-adrenergic-mediated regulation of nutritive blood flow was assessed by microdialysis perfusion of acetylcholine, sodium nitroprusside, N(G)-monomethyl-L-arginine, norepinephrine, or phentolamine. Pretraining nutritive blood flow was attenuated in aged compared with young women (7.39 ± 1.5 vs. 15.5 ± 1.9 ml·100 g(−1)·min(−1), P = 0.018), but not aged men (aged 13.5 ± 3.7 vs. young 9.4 ± 1.3 ml·100 g(−1)·min(−1), P = 0.747). There were no age-associated differences in NO-mediated or α-adrenergic-mediated nutritive blood flow. Exercise training increased resting nutritive blood flow only in young men (9.4 ± 1.3 vs. 19.7 ml·100 g(−1)·min(−1), P = 0.005). The vasodilatory effect of phentolamine was significantly reduced following exercise training only in young men (12.3 ± 6.14 vs. −3.68 ± 3.26 ml·100 g(−1)·min(−1), P = 0.048). In conclusion, the age-associated attenuation of resting nutritive skeletal muscle blood flow was specific to women, while the exercise-induced alleviation of α-adrenergic mediated vasoconstriction that was specific to young men suggests an age-associated modulation of the sympathetic response to exercise training. |
| doi_str_mv | 10.1152/ajpheart.00247.2014 |
| format | Article |
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Age-associated changes in vascular structure and function may manifest in impaired nutritive blood flow, although the regulation of nutritive blood flow in healthy aging is not well understood. The purpose of this study was to determine if nitric oxide (NO)-mediated or α-adrenergic-mediated regulation of nutritive skeletal muscle blood flow is impaired with advanced age, and if exercise training improves age-related deficiencies. Nutritive blood flow was monitored in the vastus lateralis of healthy young and aged men and women via the microdialysis-ethanol technique prior to and following seven consecutive days of exercise training. NO-mediated and α-adrenergic-mediated regulation of nutritive blood flow was assessed by microdialysis perfusion of acetylcholine, sodium nitroprusside, N(G)-monomethyl-L-arginine, norepinephrine, or phentolamine. Pretraining nutritive blood flow was attenuated in aged compared with young women (7.39 ± 1.5 vs. 15.5 ± 1.9 ml·100 g(−1)·min(−1), P = 0.018), but not aged men (aged 13.5 ± 3.7 vs. young 9.4 ± 1.3 ml·100 g(−1)·min(−1), P = 0.747). There were no age-associated differences in NO-mediated or α-adrenergic-mediated nutritive blood flow. Exercise training increased resting nutritive blood flow only in young men (9.4 ± 1.3 vs. 19.7 ml·100 g(−1)·min(−1), P = 0.005). The vasodilatory effect of phentolamine was significantly reduced following exercise training only in young men (12.3 ± 6.14 vs. −3.68 ± 3.26 ml·100 g(−1)·min(−1), P = 0.048). In conclusion, the age-associated attenuation of resting nutritive skeletal muscle blood flow was specific to women, while the exercise-induced alleviation of α-adrenergic mediated vasoconstriction that was specific to young men suggests an age-associated modulation of the sympathetic response to exercise training.</description><identifier>ISSN: 0363-6135</identifier><identifier>EISSN: 1522-1539</identifier><identifier>DOI: 10.1152/ajpheart.00247.2014</identifier><identifier>PMID: 24951753</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Acetylcholine - pharmacology ; Adrenergic alpha-Agonists - pharmacology ; Adrenergic alpha-Antagonists - pharmacology ; Adult ; Aged ; Aging ; Call for Papers ; Enzyme Inhibitors - pharmacology ; Exercise ; Female ; Humans ; Male ; Middle Aged ; Muscle, Skeletal - blood supply ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - physiology ; Nitric Oxide Donors - pharmacology ; Nitroprusside - pharmacology ; Norepinephrine - pharmacology ; omega-N-Methylarginine - pharmacology ; Phentolamine - pharmacology ; Regional Blood Flow ; Sex Factors ; Vasoconstriction ; Vasodilator Agents - pharmacology</subject><ispartof>American journal of physiology. Heart and circulatory physiology, 2014-08, Vol.307 (4), p.H524-H532</ispartof><rights>Copyright © 2014 the American Physiological Society 2014 American Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-33fdd4bf085f7a0e43d447b26155dc735e84390d8539c0ee4fa408ade8fc9c9b3</citedby><cites>FETCH-LOGICAL-c438t-33fdd4bf085f7a0e43d447b26155dc735e84390d8539c0ee4fa408ade8fc9c9b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,3026,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24951753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>La Favor, Justin D</creatorcontrib><creatorcontrib>Kraus, Raymond M</creatorcontrib><creatorcontrib>Carrithers, Jonathan A</creatorcontrib><creatorcontrib>Roseno, Steven L</creatorcontrib><creatorcontrib>Gavin, Timothy P</creatorcontrib><creatorcontrib>Hickner, Robert C</creatorcontrib><title>Sex differences with aging in nutritive skeletal muscle blood flow: impact of exercise training, nitric oxide, and α-adrenergic-mediated mechanisms</title><title>American journal of physiology. Heart and circulatory physiology</title><addtitle>Am J Physiol Heart Circ Physiol</addtitle><description>The incidence of cardiovascular disease increases progressively with age, but aging may affect men and women differently. Age-associated changes in vascular structure and function may manifest in impaired nutritive blood flow, although the regulation of nutritive blood flow in healthy aging is not well understood. The purpose of this study was to determine if nitric oxide (NO)-mediated or α-adrenergic-mediated regulation of nutritive skeletal muscle blood flow is impaired with advanced age, and if exercise training improves age-related deficiencies. Nutritive blood flow was monitored in the vastus lateralis of healthy young and aged men and women via the microdialysis-ethanol technique prior to and following seven consecutive days of exercise training. NO-mediated and α-adrenergic-mediated regulation of nutritive blood flow was assessed by microdialysis perfusion of acetylcholine, sodium nitroprusside, N(G)-monomethyl-L-arginine, norepinephrine, or phentolamine. Pretraining nutritive blood flow was attenuated in aged compared with young women (7.39 ± 1.5 vs. 15.5 ± 1.9 ml·100 g(−1)·min(−1), P = 0.018), but not aged men (aged 13.5 ± 3.7 vs. young 9.4 ± 1.3 ml·100 g(−1)·min(−1), P = 0.747). There were no age-associated differences in NO-mediated or α-adrenergic-mediated nutritive blood flow. Exercise training increased resting nutritive blood flow only in young men (9.4 ± 1.3 vs. 19.7 ml·100 g(−1)·min(−1), P = 0.005). The vasodilatory effect of phentolamine was significantly reduced following exercise training only in young men (12.3 ± 6.14 vs. −3.68 ± 3.26 ml·100 g(−1)·min(−1), P = 0.048). In conclusion, the age-associated attenuation of resting nutritive skeletal muscle blood flow was specific to women, while the exercise-induced alleviation of α-adrenergic mediated vasoconstriction that was specific to young men suggests an age-associated modulation of the sympathetic response to exercise training.</description><subject>Acetylcholine - pharmacology</subject><subject>Adrenergic alpha-Agonists - pharmacology</subject><subject>Adrenergic alpha-Antagonists - pharmacology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aging</subject><subject>Call for Papers</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Exercise</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle, Skeletal - blood supply</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscle, Skeletal - physiology</subject><subject>Nitric Oxide Donors - pharmacology</subject><subject>Nitroprusside - pharmacology</subject><subject>Norepinephrine - pharmacology</subject><subject>omega-N-Methylarginine - pharmacology</subject><subject>Phentolamine - pharmacology</subject><subject>Regional Blood Flow</subject><subject>Sex Factors</subject><subject>Vasoconstriction</subject><subject>Vasodilator Agents - pharmacology</subject><issn>0363-6135</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctuVSEUhonR2GP1CUwMQwfdR9jAvjgwMU29JE0cVMeEDYtzqGw4Ars9vkdfxBfxmaT2Ep11xGD96-eDD6GXlKwpFe0bdb7bgkplTUjL-3VLKH-EVnXSNlSw8TFaEdaxpqNMHKBnOZ8TQkTfsafooOWjoL1gK3R1BntsnLWQIGjI-NKVLVYbFzbYBRyWklxxF4Dzd_BQlMfzkrUHPPkYDbY-Xr7Fbt4pXXC0GPaQtMuAS1Iu1JIjHFyt0DjunYEjrILBv381ytTrIG2cbmYwThUweAa9VcHlOT9HT6zyGV7cnofo24eTr8efmtMvHz8fvz9tNGdDaRizxvDJkkHYXhHgzHDeT21HhTC6ZwIGzkZihvobmgBwqzgZlIHB6lGPEztE7256d8tUMTSEiu3lLrlZpZ8yKif_nwS3lZt4ITllPW27WvD6tiDFHwvkImeXNXivAsQlS9q1laYysAdFxVj52xplN1GdYs4J7D0RJfJavbxTL_-ql9fq69arfx9zv3Pnmv0B2bSxRA</recordid><startdate>20140815</startdate><enddate>20140815</enddate><creator>La Favor, Justin D</creator><creator>Kraus, Raymond M</creator><creator>Carrithers, Jonathan A</creator><creator>Roseno, Steven L</creator><creator>Gavin, Timothy P</creator><creator>Hickner, Robert C</creator><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TS</scope><scope>5PM</scope></search><sort><creationdate>20140815</creationdate><title>Sex differences with aging in nutritive skeletal muscle blood flow: impact of exercise training, nitric oxide, and α-adrenergic-mediated mechanisms</title><author>La Favor, Justin D ; Kraus, Raymond M ; Carrithers, Jonathan A ; Roseno, Steven L ; Gavin, Timothy P ; Hickner, Robert C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-33fdd4bf085f7a0e43d447b26155dc735e84390d8539c0ee4fa408ade8fc9c9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Adrenergic alpha-Agonists - pharmacology</topic><topic>Adrenergic alpha-Antagonists - pharmacology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aging</topic><topic>Call for Papers</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Exercise</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle, Skeletal - blood supply</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Muscle, Skeletal - physiology</topic><topic>Nitric Oxide Donors - pharmacology</topic><topic>Nitroprusside - pharmacology</topic><topic>Norepinephrine - pharmacology</topic><topic>omega-N-Methylarginine - pharmacology</topic><topic>Phentolamine - pharmacology</topic><topic>Regional Blood Flow</topic><topic>Sex Factors</topic><topic>Vasoconstriction</topic><topic>Vasodilator Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>La Favor, Justin D</creatorcontrib><creatorcontrib>Kraus, Raymond M</creatorcontrib><creatorcontrib>Carrithers, Jonathan A</creatorcontrib><creatorcontrib>Roseno, Steven L</creatorcontrib><creatorcontrib>Gavin, Timothy P</creatorcontrib><creatorcontrib>Hickner, Robert C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>La Favor, Justin D</au><au>Kraus, Raymond M</au><au>Carrithers, Jonathan A</au><au>Roseno, Steven L</au><au>Gavin, Timothy P</au><au>Hickner, Robert C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex differences with aging in nutritive skeletal muscle blood flow: impact of exercise training, nitric oxide, and α-adrenergic-mediated mechanisms</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><addtitle>Am J Physiol Heart Circ Physiol</addtitle><date>2014-08-15</date><risdate>2014</risdate><volume>307</volume><issue>4</issue><spage>H524</spage><epage>H532</epage><pages>H524-H532</pages><issn>0363-6135</issn><eissn>1522-1539</eissn><abstract>The incidence of cardiovascular disease increases progressively with age, but aging may affect men and women differently. Age-associated changes in vascular structure and function may manifest in impaired nutritive blood flow, although the regulation of nutritive blood flow in healthy aging is not well understood. The purpose of this study was to determine if nitric oxide (NO)-mediated or α-adrenergic-mediated regulation of nutritive skeletal muscle blood flow is impaired with advanced age, and if exercise training improves age-related deficiencies. Nutritive blood flow was monitored in the vastus lateralis of healthy young and aged men and women via the microdialysis-ethanol technique prior to and following seven consecutive days of exercise training. NO-mediated and α-adrenergic-mediated regulation of nutritive blood flow was assessed by microdialysis perfusion of acetylcholine, sodium nitroprusside, N(G)-monomethyl-L-arginine, norepinephrine, or phentolamine. Pretraining nutritive blood flow was attenuated in aged compared with young women (7.39 ± 1.5 vs. 15.5 ± 1.9 ml·100 g(−1)·min(−1), P = 0.018), but not aged men (aged 13.5 ± 3.7 vs. young 9.4 ± 1.3 ml·100 g(−1)·min(−1), P = 0.747). There were no age-associated differences in NO-mediated or α-adrenergic-mediated nutritive blood flow. Exercise training increased resting nutritive blood flow only in young men (9.4 ± 1.3 vs. 19.7 ml·100 g(−1)·min(−1), P = 0.005). The vasodilatory effect of phentolamine was significantly reduced following exercise training only in young men (12.3 ± 6.14 vs. −3.68 ± 3.26 ml·100 g(−1)·min(−1), P = 0.048). In conclusion, the age-associated attenuation of resting nutritive skeletal muscle blood flow was specific to women, while the exercise-induced alleviation of α-adrenergic mediated vasoconstriction that was specific to young men suggests an age-associated modulation of the sympathetic response to exercise training.</abstract><cop>United States</cop><pub>American Physiological Society</pub><pmid>24951753</pmid><doi>10.1152/ajpheart.00247.2014</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Acetylcholine - pharmacology Adrenergic alpha-Agonists - pharmacology Adrenergic alpha-Antagonists - pharmacology Adult Aged Aging Call for Papers Enzyme Inhibitors - pharmacology Exercise Female Humans Male Middle Aged Muscle, Skeletal - blood supply Muscle, Skeletal - drug effects Muscle, Skeletal - physiology Nitric Oxide Donors - pharmacology Nitroprusside - pharmacology Norepinephrine - pharmacology omega-N-Methylarginine - pharmacology Phentolamine - pharmacology Regional Blood Flow Sex Factors Vasoconstriction Vasodilator Agents - pharmacology |
| title | Sex differences with aging in nutritive skeletal muscle blood flow: impact of exercise training, nitric oxide, and α-adrenergic-mediated mechanisms |
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