Therapeutic Potential of Targeting the Oncogenic SHP2 Phosphatase

The Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) is an oncogenic phosphatase associated with various kinds of leukemia and solid tumors. Thus, there is substantial interest in developing SHP2 inhibitors as potential anticancer and antileukemia agents. Using a structure-guid...

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Veröffentlicht in:	Journal of medicinal chemistry 2014-08, Vol.57 (15), p.6594-6609
Hauptverfasser:	Zeng, Li-Fan, Zhang, Ruo-Yu, Yu, Zhi-Hong, Li, Sijiu, Wu, Li, Gunawan, Andrea M, Lane, Brandon S, Mali, Raghuveer S, Li, Xingjun, Chan, Rebecca J, Kapur, Reuben, Wells, Clark D, Zhang, Zhong-Yin
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cell Line, Tumor Drug Screening Assays, Antitumor Enzyme Activation Humans Indoles - chemical synthesis Indoles - chemistry Indoles - pharmacology Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Molecular Docking Simulation Molecular Targeted Therapy Protein Conformation Protein Tyrosine Phosphatase, Non-Receptor Type 11 - chemistry Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism Proto-Oncogene Proteins c-akt - metabolism Signal Transduction Small Molecule Libraries Structure-Activity Relationship
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