Mutation-independent rescue of a novel mouse model of Retinitis Pigmentosa

Retinitis Pigmentosa (RP) is the leading cause of inherited blindness in the developed world, affecting approximately 1 in 3000 individuals. Although there is currently no cure for RP, the genetic pathology has been well established. In this study, we developed a novel mouse model of RP (huRhoP347S)...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Gene therapy 2013-04, Vol.20 (4), p.425-434
Hauptverfasser:	Greenwald, D L, Cashman, S M, Kumar-Singh, R
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/51/201 631/1647/2300/1514 631/337/384/331 692/1807/1482 Adeno-associated virus Animals Biomedical and Life Sciences Biomedicine Blindness Cell Biology Dependovirus - genetics Disease Models, Animal Electroretinograms Expression vectors Eye Eye diseases Gene Expression Gene mutations Gene Silencing Gene Therapy Genetic aspects Genetic Therapy Health aspects Human Genetics Mice - genetics MicroRNAs MicroRNAs - metabolism miRNA Mutation Mutation, Missense Nanotechnology original-article Photoreceptor Cells, Vertebrate - metabolism Photoreceptors Physiological aspects Retinal degeneration Retinitis Retinitis pigmentosa Retinitis Pigmentosa - genetics Retinitis Pigmentosa - pathology Retinitis Pigmentosa - therapy Rhodopsin Rhodopsin - genetics Rhodopsin - metabolism Rodents Serotypes Transgenes Tropism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!