Genetic and Molecular Basis of Drug Resistance and Species-Specific Drug Action in Schistosome Parasites

Oxamniquine resistance evolved in the human blood fluke (Schistosoma monsoni) in Brazil in the 1970s. We crossed parental parasites differing -500-fold in drug response, determined drug sensitivity and marker segregation in clonally derived second-generation progeny, and identified a single quantita...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2013-12, Vol.342 (6164), p.1385-1389
Hauptverfasser:	Valentim, Claudia L. L., Cioli, Donato, Chevalier, Frédéric D., Cao, Xiaohang, Taylor, Alexander B., Holloway, Stephen P., Pica-Mattoccia, Livia, Guidi, Alessandra, Basso, Annalisa, Tsai, Isheng J., Berriman, Matthew, Carvalho-Queiroz, Claudia, Almeida, Marcio, Aguilar, Hector, Frantz, Doug E., Hart, P. John, LoVerde, Philip T., Anderson, Timothy J. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Africa Amino Acid Sequence Animals Antimicrobial agents blood flukes chromosome mapping Complementation drug resistance Drug Resistance - genetics drugs Embryology freshwater Gene Knockdown Techniques Genes Genetic Linkage Genetic mutation Genetics Genomes genomics Helminth Proteins - genetics Humans larvae Molecular Sequence Data Mutation Oxamniquine - pharmacology Parasites Parasitic diseases people Pharmacologic actions Pharmacology Phylogeny praziquantel Protein Conformation Proteins Quantitative Trait Loci RNA Interference Schistosoma mansoni Schistosoma mansoni - drug effects Schistosoma mansoni - genetics schistosomiasis Schistosomicides - pharmacology sequence analysis snails South America Sulfotransferases - chemistry Sulfotransferases - classification Sulfotransferases - genetics Trematoda water pollution Worms X-ray diffraction
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