Endosomal trafficking of nanoformulated antiretroviral therapy facilitates drug particle carriage and HIV clearance

Limitations of antiretroviral therapy (ART) include poor patient adherence, drug toxicities, viral resistance, and failure to penetrate viral reservoirs. Recent developments in nanoformulated ART (nanoART) could overcome such limitations. To this end, we now report a novel effect of nanoART that fac...

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Veröffentlicht in:	Journal of virology 2014-09, Vol.88 (17), p.9504-9513
Hauptverfasser:	Guo, Dongwei, Zhang, Gang, Wysocki, Tadeusz A, Wysocki, Beata J, Gelbard, Harris A, Liu, Xin-Ming, McMillan, JoEllyn M, Gendelman, Howard E
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Retroviral Agents - pharmacokinetics Anti-Retroviral Agents - pharmacology Atazanavir Sulfate Biological Transport Cells, Cultured Endosomes - metabolism HIV Core Protein p24 - analysis HIV-1 - drug effects HIV-1 - growth & development Human immunodeficiency virus 1 Humans Macrophages - metabolism Microscopy, Confocal Microscopy, Fluorescence Models, Theoretical Nanoparticles Oligopeptides - pharmacokinetics Oligopeptides - pharmacology Poloxamer - pharmacokinetics Poloxamer - pharmacology Pyridines - pharmacokinetics Pyridines - pharmacology Virus Cultivation Virus-Cell Interactions
Online-Zugang:	Volltext
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