A rapid matrix-assisted laser desorption ionization-time of flight mass spectrometry-based method for single-plasmid tracking in an outbreak of carbapenem-resistant Enterobacteriaceae

Carbapenem-resistant Enterobacteriaceae (CRE) have spread globally and represent a serious and growing threat to public health. Rapid methods for tracking plasmids carrying carbapenemase genes could greatly benefit infection control efforts. Here, we demonstrate that real-time, direct tracking of a...

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Veröffentlicht in:	Journal of clinical microbiology 2014-08, Vol.52 (8), p.2804-2812
Hauptverfasser:	Lau, Anna F, Wang, Honghui, Weingarten, Rebecca A, Drake, Steven K, Suffredini, Anthony F, Garfield, Mark K, Chen, Yong, Gucek, Marjan, Youn, Jung-Ho, Stock, Frida, Tso, Hanna, DeLeo, Jim, Cimino, James J, Frank, Karen M, Dekker, John P
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Bacterial Proteins - analysis Bacterial Proteins - chemistry Bacterial Typing Techniques - methods Bacteriology beta-Lactam Resistance Carbapenems - pharmacology Disease Outbreaks DNA, Bacterial - chemistry DNA, Bacterial - genetics Enterobacteriaceae Enterobacteriaceae - chemistry Enterobacteriaceae - classification Enterobacteriaceae - genetics Enterobacteriaceae - isolation & purification Enterobacteriaceae Infections - epidemiology Enterobacteriaceae Infections - microbiology Genes, Bacterial Humans Klebsiella pneumoniae Molecular Epidemiology - methods Molecular Weight Plasmids - analysis Sequence Analysis, DNA Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Time Factors
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