Highly Sulfated K5 Escherichia coli Polysaccharide Derivatives Inhibit Respiratory Syncytial Virus Infectivity in Cell Lines and Human Tracheal-Bronchial Histocultures

Respiratory syncytial virus (RSV) exploits cell surface heparan sulfate proteoglycans (HSPGs) as attachment receptors. The interaction between RSV and HSPGs thus presents an attractive target for the development of novel inhibitors of RSV infection. In this study, selective chemical modification of...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2014-08, Vol.58 (8), p.4782-4794
Hauptverfasser:	CAGNO, Valeria, DONALISIO, Manuela, CIVRA, Andrea, VOLANTE, Marco, VECCELLI, Elena, ORESTE, Pasqua, RUSNATI, Marco, LEMBO, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral Agents Antiviral Agents - isolation & purification Antiviral Agents - pharmacology Bacterial Capsules Bacterial Capsules - chemistry Biological and medical sciences Bronchi - drug effects Bronchi - virology Cell Line Cell Survival - drug effects Dose-Response Relationship, Drug Epithelial Cells - drug effects Epithelial Cells - pathology Epithelial Cells - virology Escherichia coli Escherichia coli - chemistry Giant Cells - drug effects Giant Cells - ultrastructure Heparin - pharmacology Human viral diseases Humans Infectious diseases Medical sciences Pharmacology. Drug treatments Polysaccharides, Bacterial Polysaccharides, Bacterial - isolation & purification Polysaccharides, Bacterial - pharmacology Respiratory syncytial virus Respiratory Syncytial Virus, Human Respiratory Syncytial Virus, Human - drug effects Respiratory Syncytial Virus, Human - physiology Tissue Culture Techniques Trachea - drug effects Trachea - virology Viral diseases Viral diseases of the respiratory system and ent viral diseases Viral Load - drug effects Viral Plaque Assay Virus Attachment Virus Attachment - drug effects Virus Replication - drug effects
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