Safety and pharmacokinetics of XOMA 3AB, a novel mixture of three monoclonal antibodies against botulinum toxin A

Botulinum neurotoxin A is a category A bioterrorism agent. Current antitoxin therapies are scarce and produce adverse reactions. XOMA 3AB consists of 3 IgG1 monoclonal antibodies (MAbs), each with a distinct human or humanized variable region, which bind to distinct epitopes on botulinum neurotoxin...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2014-09, Vol.58 (9), p.5047-5053
Hauptverfasser:	Nayak, S U, Griffiss, J M, McKenzie, R, Fuchs, E J, Jurao, R A, An, A T, Ahene, A, Tomic, M, Hendrix, C W, Zenilman, J M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Antibodies, Monoclonal Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal - pharmacokinetics Area Under Curve Botulinum Toxins, Type A Botulinum Toxins, Type A - antagonists & inhibitors Clostridium botulinum Double-Blind Method Female Humans Male Mice Pharmacology Young Adult
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