Accumulation of Phosphatidic Acid Increases Vancomycin Resistance in Escherichia coli

In Gram-negative bacteria, lipopolysaccharide (LPS) contributes to the robust permeability barrier of the outer membrane, preventing entry of toxic molecules such as antibiotics. Mutations in lptD, the beta-barrel component of the LPS transport and assembly machinery, compromise LPS assembly and res...

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Veröffentlicht in:	Journal of bacteriology 2014-09, Vol.196 (18), p.3214-3220
Hauptverfasser:	Sutterlin, Holly A, Zhang, Sisi, Silhavy, Thomas J
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Acylglycerol-3-Phosphate O-Acyltransferase - genetics 1-Acylglycerol-3-Phosphate O-Acyltransferase - metabolism Anti-Bacterial Agents - pharmacology Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - metabolism Bacteriology biogenesis biosynthesis cell walls Chromatography Chromatography, Liquid - methods Escherichia coli Escherichia coli - drug effects Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Gene Expression Regulation, Bacterial - physiology genes Gram-negative bacteria Lipids lipopolysaccharides liquid chromatography Mass spectrometry Mass Spectrometry - methods Molecules Mutation Nucleotidyltransferases - genetics Nucleotidyltransferases - metabolism peptidoglycans Permeability Phosphatidic Acids - metabolism phospholipids Phospholipids - metabolism toxicity vancomycin Vancomycin - pharmacology Vancomycin Resistance
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